Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Long-Fei Mao"'
Autor:
En Gao, Ya Wang, Gao-lu Fan, Guiqing Xu, Zi-Yuan Wu, Zi-Jun Liu, Jian-Cheng Liu, Long-Fei Mao, Xixi Hou, Shouhu Li
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract A series of 20 novel gefitinib derivatives incorporating the 1,2,3-triazole moiety were designed and synthesized. The synthesized compounds were evaluated for their potential anticancer activity against EGFR wild-type human non-small cell lu
Externí odkaz:
https://doaj.org/article/f84713dadc2c4faf94fc6075ebdfa619
Autor:
Xi-Xi Hou, Long-Fei Mao, Yajie Guo, Chaoxuan Lou, Lan Wang, Rui-Fang Li, Huili Wang, San-Qiang Li, Jian-Xue Yang
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Based on the modification of the structure of dolutegravir, we introduced 1,2,3-triazole moieties with different substituted groups and obtained a lot of novel dolutegravir derivatives. The activity of A549 cells treated with the derivatives was exam
Externí odkaz:
https://doaj.org/article/137fb1eea7174cd8a708aedb91010b8b
Publikováno v:
Frontiers in Chemistry, Vol 11 (2023)
Indoleamine 2,3-dioxygenase 1 (IDO1) has attracted much attention in the field of cancer immunotherapy as an immunomodulatory enzyme. To identify potential IDO1 inhibitors, a novel series of compounds with N,N-diphenylurea and triazole structures wer
Externí odkaz:
https://doaj.org/article/a17453182b8b4402974fcb3b9e41ca7c
Autor:
Xiaojie Chen, Long-Fei Mao, Siqi Tian, Xueli Tian, Xueqiong Meng, Mu-Kuo Wang, Weifeng Xu, Yue-Ming Li, Kangdong Liu, Zigang Dong
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Previous report showed that a variety of icotinib derivatives bearing different 1,2,3-triazole moieties, which could be readily prepared via copper (I)-catalyzed cycloaddition (CuAAC) reaction between icotinib and different azides, exhibited interest
Externí odkaz:
https://doaj.org/article/c9faeb1fd23c406d9546abed11562efa
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Erlotinib is a highly specific and reversible epidermal growth factor receptor tyrosine kinase inhibitor for the targeted therapy of non-small-cell lung cancer (NSCLC) However, the efficacy of erlotinib is limited because the development of drug resi
Externí odkaz:
https://doaj.org/article/303f821c77b2496a80ba8f78f937dab6
Autor:
Gui-Qing Xu, Xiao-Qing Gong, Ying-Ying Zhu, Xiao-Jun Yao, Li-Zeng Peng, Ge Sun, Jian-Xue Yang, Long-Fei Mao
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Indoleamine 2,3-dioxygenase 1 (IDO1) plays a predominant role in cancer immunotherapy which catalyzes the initial and rate limiting steps of the kynurenine pathway as a key enzyme. To explore novel IDO1 inhibitors, five derivatives of erlotinib-linke
Externí odkaz:
https://doaj.org/article/a3c1820140b647d7b91984df65109fae
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Nineteen erlotinib derivatives bearing different 1,2,3-triazole moieties were designed, synthesized, and evaluated for their potential against different cancer cell lines. The structures of the synthesized compounds were confirmed via1H NMR, 13C NMR,
Externí odkaz:
https://doaj.org/article/61b2911d170c49a9976383264c7eac6c
Publikováno v:
Polymers, Vol 14, Iss 14, p 2899 (2022)
The ethanol precipitation method has been widely-used for Dendrobium officinale polysaccharides preparation. However, the alcohol-soluble fractions have always been ignored, which causes significant wastes of resources and energies. In this study, th
Externí odkaz:
https://doaj.org/article/cdd96e2f09c247e1b9d09a78450d02d9
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 9 (2021)
In this study, acenaphthylene was used as the raw material, and a series of novel 1,8-naphthalimide-1,2,3-triazole derivatives was obtained through oxidation, acylation, alkylation, and click reactions, and subsequently, their anti-tumor activities w
Externí odkaz:
https://doaj.org/article/5a51d634226040399647681a95b7e7f5
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Tumor immunotherapy is considered to be a highlight in cancer treatment in recent years. Indoleamine 2,3-dioxygenase 1 (IDO1) is closely related to the over expression of many cancers, and is therefore a promising target for tumor immunotherapy. To s
Externí odkaz:
https://doaj.org/article/65879cc8421444bba470c0e4e6d371db