Specific Gain and Loss of Co-Expression Modules in Long-Lived Individuals Indicate a Role of circRNAs in Human Longevity

Autor: Ming-Xia Ge, Jian-Jun Jiang, Li-Qin Yang, Xing-Li Yang, Yong-Han He, Gong-Hua Li, Qing-Peng Kong

Publikováno v: Genes; Volume 13; Issue 5; Pages: 749

Deep RNA sequencing of 164 blood samples collected from long-lived families was performed to investigate the expression patterns of circular RNAs (circRNAs). Unlike that observed in previous studies, circRNA expression in long-lived elderly individua

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6c86559aa7224546ce023851602722b
https://pubmed.ncbi.nlm.nih.gov/35627134

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Prevalence of clinically actionable disease variants in exceptionally long-lived families

Autor: Joseph M. Zmuda, Todd E. Druley, Bharat Thyagarajan, Joseph H. Lee, Mary K. Wojczynski, Paige Carlson

Publikováno v: BMC Medical Genomics, Vol 13, Iss 1, Pp 1-7 (2020)
BMC Medical Genomics

Background Phenotypic expression of pathogenic variants in individuals with no family history of inherited disorders remains unclear. Methods We evaluated the prevalence of pathogenic variants in 25 genes associated with Mendelian-inherited disorders

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c241aad73b0ebfc0576b121f323857f9
https://doi.org/10.1186/s12920-020-0710-5

The Survival of Spouses Marrying Into Longevity-Enriched Families

Autor: Eric Stallard, Kaare Christensen, Jacob Pedersen, Nicole Schupf, Irma T. Elo, Anatoliy I. Yashin, Thomas T. Perls

Publikováno v: Pedersen, J K, Elo, I T, Schupf, N, Perls, T T, Stallard, E, Yashin, A I & Christensen, K 2017, ' The Survival of Spouses Marrying Into Longevity-Enriched Families ', Journals of Gerontology. Series A: Biological Sciences & Medical Sciences, vol. 72, no. 1, pp. 109-114 . https://doi.org/10.1093/gerona/glw159

BACKGROUND: Studies of longevity-enriched families are an important tool to gain insight into the mechanisms of exceptionally long and healthy lives. In the Long Life Family Study, the spouses of the members of the longevity-enriched families are oft

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a7ab1ba35e782ecdbe6d726f4e5afb6
https://portal.findresearcher.sdu.dk/da/publications/afd23639-019f-4089-9c82-27ed52882b3f

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