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Akademický článek

Inhibition of mitotic kinase Aurora suppresses Akt-1 activation and induces apoptotic cell death in all-trans retinoid acid-resistant acute promyelocytic leukemia cells

Autor: Long Zi-Jie, Huang Shan, Xu Duo-Rong, Chen Jia-Jie, Zou Zheng-Zhi, Li Juan, Lin Dong-Jun, Liu Quentin

Publikováno v: Journal of Translational Medicine, Vol 9, Iss 1, p 74 (2011)

Abstract Background Aurora kinase ensures accurate chromosome segregation during cell cycle, maintaining genetic integrity in cell division. VX-680, a small-molecule Aurora kinase inhibitor, interferes with mitotic entry and formation of bipolar spin

Externí odkaz: https://doaj.org/article/95cfa6210f46434484e3c9185c8099cf

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Akademický článek

Curcumin reduces expression of Bcl-2, leading to apoptosis in daunorubicin-insensitive CD34+ acute myeloid leukemia cell lines and primary sorted CD34+ acute myeloid leukemia cells

Autor: Huang Sheng-Shan, Long Zi-Jie, Zheng Fei-Meng, Xu Duo-Rong, Rao Jia, Wu Xing, Zhou Wei-Hua, Huang Ren-Wei, Liu Quentin

Publikováno v: Journal of Translational Medicine, Vol 9, Iss 1, p 71 (2011)

Abstract Background Acute myeloid leukemia (AML) is an immunophenotypically heterogenous malignant disease, in which CD34 positivity is associated with poor prognosis. CD34+ AML cells are 10-15-fold more resistant to daunorubicin (DNR) than CD34- AML

Externí odkaz: https://doaj.org/article/9b1cebde405a4908bd70bddc9b2349f8

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Akademický článek

Pluripotency-associated genes in human nasopharyngeal carcinoma CNE-2 cells are reactivated by a unique epigenetic sub-microenvironment

Autor: Zheng Fei-Meng, Liang Yi, Lin Ji-Yan, Dai Zhong-Min, Long Zi-Jie, Cui Yu-Xin, Cao Jun-Xia, Zeng Yi-Xin, Liu Quentin

Publikováno v: BMC Cancer, Vol 10, Iss 1, p 68 (2010)

Abstract Background There is increasing evidence that cancers contain their own stem-like cells, and particular attention has been paid to one subset of cancer-stem cells termed side population (SP). Stem cells under normal physical conditions are ti

Externí odkaz: https://doaj.org/article/83aeee373ca246adbfc61068d1343b2d

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Akademický článek

Aurora-A down-regulates IkappaBα via Akt activation and interacts with insulin-like growth factor-1 induced phosphatidylinositol 3-kinase pathway for cancer cell survival

Autor: Li Ming-wei, Zhao Yan, Long Zi-jie, Wang Li-hui, Li Chuan-xing, Xia Liang-ping, Pan Chao-bin, Guan Zhong, Yan Min, Yao Jin-e, Zheng Fei-meng, Xu Jie, Lin Dong-jun, Liu Quentin

Publikováno v: Molecular Cancer, Vol 8, Iss 1, p 95 (2009)

Abstract Background The mitotic Aurora-A kinase exerts crucial functions in maintaining mitotic fidelity. As a bona fide oncoprotein, Aurora-A aberrant overexpression leads to oncogenic transformation. Yet, the mechanisms by which Aurora-A enhances c

Externí odkaz: https://doaj.org/article/fad6e8fc17cf44c6ab85858c3badadce

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