Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Long Xuan Zhao"'
Autor:
Yanqiu Qi, Jinfeng Sun, Yu-Ting Jin, Gao Li, Shengbao Diao, Long-Xuan Zhao, Mei Jin, Wei Zhou
Publikováno v:
Journal of Asian Natural Products Research. 24:849-859
Twelve novel cordycepin derivatives were designed and synthesized with modification at positions of 2', 5'-hydroxyl and N6 amino groups of cordycepin. The results showed that the inhibitory activities of 3, 4b, 6c and 6d on A549 were comparable to th
Autor:
Long-Xuan Zhao, Tian Tian, Jiaqi Li, Yang Zhang, Bin Feng, Xiyue Zhang, Jiawen Yu, Chunhui Zhao
Publikováno v:
Chemical and Pharmaceutical Bulletin. 68:962-970
Oleanolic and ursolic acids were used as lead compounds to synthesize a series of pentacyclic triterpenoid derivatives bearing ethylenediamine, butanediamine, or hexanediamine groups at the C-3 position. The potential antiproliferative activity of th
Publikováno v:
Medicinal Chemistry Research.
A series of glycyrrhetinic acid, oleanolic acid and ursolic acid derivatives were designed and synthesized. Structures of all novel compounds were determined by 1H NMR, 13C NMR, and HRMS methods. In vitro anti-proliferative effects of all compounds w
Publikováno v:
CHEMICAL & PHARMACEUTICAL BULLETIN. 65:276-283
A series of deoxycholic acid (DCA) derivatives bearing amino acid moiety has been synthesized and investigated for their potential antiproliferative activities. DCA derivative compounds were synthesized by a two or three step synthetic approach. Thei
Autor:
Ji-seong Yoon, Hong-Rae Kim, Gyudong Kim, Sang Kook Lee, Girish Chandra, Long Xuan Zhao, Akshata Nayak, Ji Yun Lee, Woong Sub Byun, Dnyandev B. Jarhad, Varughese A. Mulamoottil, Jinha Yu, Lak Shin Jeong, Yong-Chul Kim
Publikováno v:
European journal of medicinal chemistry. 155
Based on the potent anticancer activity of 6'-fluorocyclopentenyl-cytosine 2b in phase IIa clinical trials for the treatment of gemcitabine-resistant pancreatic cancer, we carried out a systematic structure-activity relationship study of 6'-fluorocyc
Autor:
Jinha, Yu, Long Xuan, Zhao, Jongmi, Park, Hyuk Woo, Lee, Pramod K, Sahu, Minghua, Cui, Steven M, Moss, Eva, Hammes, Eugene, Warnick, Zhan-Guo, Gao, Minsoo, Noh, Sun, Choi, Hee-Chul, Ahn, Jungwon, Choi, Kenneth A, Jacobson, Lak Shin, Jeong
Publikováno v:
Journal of medicinal chemistry. 60(8)
Potent and selective A3 adenosine receptor (AR) agonists were identified by replacement of 4′-oxo- or 4′-thionucleosides with bioisosteric selenium. Unlike previous agonists, 4′-seleno analogues preferred a glycosidic syn conformation and a Sou
Publikováno v:
Chemical and Pharmaceutical Bulletin. 62:764-771
A large number of bioactive pentacyclic triterpenoids have been shown to have multiple biological activities. This study was conducted to evaluate the inhibitory activities of 6 newly synthesized and novel pentacyclic triterpenoids against enteroviru
Autor:
Tian Tian, Zhonghua Feng, Eung-Seok Lee, Xinyu Liu, Chunhui Zhao, Jingyang Sun, Long-Xuan Zhao
Publikováno v:
Archives of pharmacal research. 40(4)
A series of nitrogen-containing derivatives of oleanolic acid and ursolic acid were prepared by a modification at C-28 position via esterification with 2-hydroxyacetic acid followed by amidation with amines, such as piperazine, N-methylpiperazine, an
Autor:
Won Jun Choi, Akshata Nayak, Varughese Alexander, Long Xuan Zhao, Chang H. Ahn, Hea Ok Kim, Lak Shin Jeong, Young Bok Lee, Sang Kook Lee, Girish Chandra, Jin-Hee Kim, Hwa-Jin Chung, Hyuk Woo Lee, Mahesh S. Majik
Publikováno v:
Journal of Medicinal Chemistry. 55:4521-4525
On the basis of the potent biological activity of cyclopentenyl-pyrimidines, fluorocyclopentenyl-pyrimidines were designed and synthesized from D-ribose. Among these, the cytosine derivative 5a showed highly potent antigrowth effects in a broad range
Publikováno v:
Archives of Pharmacal Research. 31:843-849
On the basis of potent anti-hepatitis C virus (HCV) activity of 2'-C-hydroxymethyladenosine, 3'-C-hydroxymethyl-substituted pyrimidine and purine nucleosides as potential anti-HCV agents were designed and synthesized from D-xylose via stereoselective