The RNA Polymerase II Core Promoter in Drosophila

Autor: Long Vo Ngoc, George A. Kassavetis, James T. Kadonaga

Publikováno v: Genetics. 212:13-24

Transcription by RNA polymerase II initiates at the core promoter, which is sometimes referred to as the “gateway to transcription.” Here, we describe the properties of the RNA polymerase II core promoter in Drosophila. The core promoter is at a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a2a360c0680dc41e085fd223b72d01b2
https://doi.org/10.1534/genetics.119.302021

ARE-mediated decay controls gene expression and cellular metabolism upon oxygen variations

Autor: Abel Garcia-Pino, Marija Dragojevic, Dukas Jurėnas, Véronique Kruys, Cyril Gueydan, Bérengère de Toeuf, Nadège Delacourt, Romuald Soin, Abdelkarim Nazih, Long Vo Ngoc

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-17 (2018)
Scientific Reports
Scientific reports, 8 (1

Hypoxia triggers profound modifications of cellular transcriptional programs. Upon reoxygenation, cells return to a normoxic gene expression pattern and mRNA produced during the hypoxic phase are degraded. TIS11 proteins control deadenylation and dec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44a3c01f4fe6197cff5fa536e81f098f
http://link.springer.com/article/10.1038/s41598-018-23551-8

Transcriptome-wide distribution and function of RNA hydroxymethylcytosine

Autor: Collin Wetzel, Patrick A. Limbach, Véronique Kruys, Bouchra Hassabi, Stephan Awe, Long Vo Ngoc, Alexander Brehm, Benjamin Delatte, François Fuks, Judith Kreher, Emilie Calonne, Cyril Gueydan, Catherine Creppe, Elise Bonvin, Romuald Soin, Matthieu Defrance, Evelyne Collignon, Pascale Putmans, Ruth Steward, Rachel Deplus, Svetlana Minakhina, Fei Wang

Publikováno v: Science. 351:282-285

Chemical modification of RNA for function Chemical modifications play an important role in modifying and regulating the function of DNA and RNA. Delatte et al. show that, in the fruit fly, many messenger RNAs (mRNAs) contain the modified base 5-hydro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e4be14051e1e0990db157359a17922ab
https://doi.org/10.1126/science.aac5253

Rapid Proteasomal Degradation of Posttranscriptional Regulators of the TIS11/Tristetraprolin Family Is Induced by an Intrinsically Unstructured Region Independently of Ubiquitination

Autor: Long Vo Ngoc, Romuald Soin, Sabrina Bousbata, Corinne Wauquier, Laure Twyffels, Véronique Kruys, Cyril Gueydan

Publikováno v: Molecular and Cellular Biology. 34:4315-4328

The TIS11/tristetraprolin (TTP) CCCH tandem zinc finger proteins are major effectors in the destabilization of mRNAs bearing AU-rich elements (ARE) in their 3′ untranslated regions. In this report, we demonstrate that the Drosophila melanogaster dT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ac9cd102b504a5e2c857a8ed1b169a3
https://doi.org/10.1128/mcb.00643-14

The human initiator is a distinct and abundant element that is precisely positioned in focused core promoters

Autor: Sascha H. Duttke, California Jack Cassidy, Long Vo Ngoc, James T. Kadonaga, Cassidy Yunjing Huang

Publikováno v: Ngoc, LV; Cassidy, CJ; Huang, CY; Duttke, SHC; & Kadonaga, JT. (2017). The human initiator is a distinct and abundant element that is precisely positioned in focused core promoters. GENES & DEVELOPMENT, 31(1), 6-11. doi: 10.1101/gad.293837.116. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/84b5j6sd
Genes & development, vol 31, iss 1

DNA sequence signals in the core promoter, such as the initiator (Inr), direct transcription initiation by RNA polymerase II. Here we show that the human Inr has the consensus of BBCA+1BW at focused promoters in which transcription initiates at a sin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcf87bee23f47db76c241b563624d527
http://www.escholarship.org/uc/item/84b5j6sd