Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Long Tai, Zheng"'
Autor:
Junjie Cheng, Rong Zhang, Zhirou Xu, Youliang Ke, Renjuan Sun, Huicui Yang, Xiaohu Zhang, Xuechu Zhen, Long-Tai Zheng
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-18 (2021)
Abstract Background Microglial activation-mediated neuroinflammation plays an important role in the progression of neurodegenerative diseases. Inflammatory activation of microglial cells is often accompanied by a metabolic switch from oxidative phosp
Externí odkaz:
https://doaj.org/article/6d3d4d626b494c44b73c826e8b0ecd7b
Autor:
Ping Gan, Li Zhang, Yanke Chen, Yu Zhang, Fali Zhang, Xiang Zhou, Xiaohu Zhang, Bo Gao, Xuechu Zhen, Jian Zhang, Long Tai Zheng
Publikováno v:
Journal of Pharmacological Sciences, Vol 128, Iss 1, Pp 35-46 (2015)
Over-activated microglia is involved in various kinds of neurodegenerative process including Parkinson, Alzheimer and HIV dementia. Suppression of microglial over activation has emerged as a novel strategy for treatment of neuroinflammation-based neu
Externí odkaz:
https://doaj.org/article/c41089bb543749afa8bd52255d3ce306
Publikováno v:
Journal of Pharmacological Sciences, Vol 125, Iss 4, Pp 364-374 (2014)
Abstract.: Overactivation of microglia may contribute to the pathogenesis of neurodegenerative diseases such as Parkinson’s disease, Alzheimer’s disease, and HIV dementia. Thus, regulating microglial activation has been an important therapeutic s
Externí odkaz:
https://doaj.org/article/c0112e88d456411ab9446c4707efccd0
Autor:
Renjuan Sun, Long Tai Zheng, Youliang Ke, Rong Zhang, Xuechu Zhen, Xiaohu Zhang, Zhirou Xu, Junjie Cheng, Huicui Yang
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-18 (2021)
Journal of Neuroinflammation
Journal of Neuroinflammation
Background Microglial activation-mediated neuroinflammation plays an important role in the progression of neurodegenerative diseases. Inflammatory activation of microglial cells is often accompanied by a metabolic switch from oxidative phosphorylatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::505434db7063b9b96b997e9994ecd8ed
https://doaj.org/article/6d3d4d626b494c44b73c826e8b0ecd7b
https://doaj.org/article/6d3d4d626b494c44b73c826e8b0ecd7b
Autor:
Long Tai Zheng, Wanwan Li, Zhongqiang Cao, Na Ye, Junjie Cheng, Feiyu Chen, Shuai Li, Yiwei Huang
Publikováno v:
Medicinal Chemistry Research. 30:1294-1308
Two series of novel NLRP3 inflammasome inhibitors are designed, synthesized, and evaluated in an effort to develop diversified analogs based on the N-(phenylcarbamoyl)benzenesulfonamide scaffold. SAR studies reveal that the sulfonylurea linker can to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c83b80fe215c564771590e69dd11c990
https://doi.org/10.1007/s00044-021-02740-7
https://doi.org/10.1007/s00044-021-02740-7
Autor:
Lei Xu, Tingjun Hou, Jie Pan, Xuechu Zhen, Pu-Qing Wang, Huan-Ting Li, Bo-Wen Gao, Sheng Tian, Zhang Yu, Long Tai Zheng, Yao Zhang
Publikováno v:
Acta Pharmacol Sin
Macrophage migration inhibitory factor (MIF) is a pluripotent pro-inflammatory cytokine and is related to acute and chronic inflammatory responses, immune disorders, tumors, and other diseases. In this study, an integrated virtual screening strategy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41370e0e02bd279dfe72b4aa3fc52389
https://europepmc.org/articles/PMC9160002/
https://europepmc.org/articles/PMC9160002/
The oncometabolite 2-hydroxyglutarate inhibits microglial activation via the AMPK/mTOR/NF-κB pathway
Autor:
Xiaohu Zhang, Jiyue Zheng, Lin Sun, Chaojun Han, Zhong-qiang Cao, Xuechu Zhen, Huicui Yang, Long Tai Zheng
Publikováno v:
Acta Pharmacol Sin
Microglia, the brain-resident macrophage, is known as the innate immune cell type in the central nervous system. Microglia is also the major cellular component of tumor mass of gliomas that plays a key role in glioma development. Mutations of isocitr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4653ef63d345405a6b4febeb4846cba
https://doi.org/10.1038/s41401-019-0225-9
https://doi.org/10.1038/s41401-019-0225-9
Autor:
Lei Xu, Zhang Yu, Jiaojiao Chen, Qijun Dai, Hua Liu, Tingjun Hou, Li Zhang, Long Tai Zheng, Xuechu Zhen
Publikováno v:
International immunopharmacology. 98
Microglial overactivation-mediated neuroinflammation contributes greatly to the pathogenesis of neurodegenerative diseases, such as Parkinson's disease. Macrophage migration inhibitory factor (MIF) is a pleiotropic proinflammatory cytokine that is in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5e0a0be4a1f757fefd5fd99b2364d01
https://pubmed.ncbi.nlm.nih.gov/34153665
https://pubmed.ncbi.nlm.nih.gov/34153665
Autor:
Junjie Cheng, Rong Zhang, Youliang Ke, Zhirou Xu, Renjuan Sun, Huicui Yang, Xuechu Zhen, Long-Tai Zheng
Background Microglial activation-mediated neuroinflammation plays an important role in the progression of neurodegenerative diseases. Inflammatory activation of microglial cells is often accompanied by a metabolic switch from oxidative phosphorylatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2a47b73ab879ac40b54e7179bbbd4d5
https://doi.org/10.21203/rs.3.rs-93481/v1
https://doi.org/10.21203/rs.3.rs-93481/v1
Autor:
Lusong Luo, Shuaishuai Chen, Haimei Xing, Sudan He, Haikuo Ma, Jiajun Li, Long Tai Zheng, Hongjian Zhang, Qin Chen, Xiaohu Zhang, Jiyue Zheng, Fang Zhu
Publikováno v:
European Journal of Medicinal Chemistry. 149:110-121
Embryonic stem cell pathways such as hedgehog and Wnt pathways are central to the tumorigenic properties of cancer stem cells (CSC). Since CSCs are characterized by their ability to self-renew, form differentiated progeny, and develop resistance to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a50f5fbe5a816af0cdc9208245fade88
https://doi.org/10.1016/j.ejmech.2018.02.034
https://doi.org/10.1016/j.ejmech.2018.02.034