Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Long Jason Lu"'
Autor:
Syn Kok Yeo, Xiaoting Zhu, Takako Okamoto, Mingang Hao, Cailian Wang, Peixin Lu, Long Jason Lu, Jun-Lin Guan
Publikováno v:
eLife, Vol 9 (2020)
Breast cancer stem cells (BCSCs) contribute to intra-tumoral heterogeneity and therapeutic resistance. However, the binary concept of universal BCSCs co-existing with bulk tumor cells is over-simplified. Through single-cell RNA-sequencing, we found t
Externí odkaz:
https://doaj.org/article/49ed72ea9a90402a841943f5b6061f2c
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58178 (2013)
Large-scale systematic analysis of gene essentiality is an important step closer toward unraveling the complex relationship between genotypes and phenotypes. Such analysis cannot be accomplished without unbiased and accurate annotations of essential
Externí odkaz:
https://doaj.org/article/1834ca55abcf499cb2f2813ef82160ff
Autor:
Xizhi Feng, Karthik Krishnan, Daryl L Richie, Vishukumar Aimanianda, Lukas Hartl, Nora Grahl, Margaret V Powers-Fletcher, Minlu Zhang, Kevin K Fuller, William C Nierman, Long Jason Lu, Jean-Paul Latgé, Laura Woollett, Simon L Newman, Robert A Cramer, Judith C Rhodes, David S Askew
Publikováno v:
PLoS Pathogens, Vol 7, Iss 10, p e1002330 (2011)
Endoplasmic reticulum (ER) stress is a condition in which the protein folding capacity of the ER becomes overwhelmed by an increased demand for secretion or by exposure to compounds that disrupt ER homeostasis. In yeast and other fungi, the accumulat
Externí odkaz:
https://doaj.org/article/e8921120d708438bbfb7eba100185cce
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e10275 (2010)
BACKGROUND:Bicoid (Bcd) is a Drosophila morphogenetic protein responsible for patterning the anterior structures in embryos. Recent experimental studies have revealed important insights into the behavior of this morphogen gradient, making it necessar
Externí odkaz:
https://doaj.org/article/80877fc34a254ab1b3af77deacf60c7c
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 10, Pp 2575-2585 (2013)
Recent applications of mass spectrometry technology have dramatically increased our understanding of the proteomic diversity of high density lipoproteins (HDL). Depending on the method of HDL isolation, upwards of 85 proteins have been identified, an
Autor:
Long Jason, Lu
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1279
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1279
Genes with indispensable functions are identified as essential; however, the traditional gene-level perspective of essentiality has several limitations. We hypothesized that protein domains, the independent structural or functional units of a polypep