Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation

Autor: Gusev, A, Shi, H, Kichaev, G, Pomerantz, M, Li, F, Long, HW, Ingles, SA, Kittles, RA, Strom, SS, Rybicki, BA, Nemesure, B, Isaacs, WB, Zheng, W, Pettaway, CA, Yeboah, ED, Tettey, Y, Biritwum, RB, Adjei, AA, Tay, E, Truelove, A, Niwa, S, Chokkalingam, AP, John, EM, Murphy, AB, Signorello, LB, Carpten, J, Leske, MC, Wu, S-Y, Hennis, AJM, Neslund-Dudas, C, Hsing, AW, Chu, L, Goodman, PJ, Klein, EA, Witte, JS, Casey, G, Kaggwa, S, Cook, MB, Stram, DO, Blot, WJ, Eeles, RA, Easton, D, Kote-Jarai, Z, Al Olama, AA, Benlloch, S, Muir, K, Giles, GG, Southey, MC, Fitzgerald, LM, Gronberg, H, Wiklund, F, Aly, M, Henderson, BE, Schleutker, J, Wahlfors, T, Tammela, TLJ, Nordestgaard, BG, Key, TJ, Travis, RC, Neal, DE, Donovan, JL, Hamdy, FC, Pharoah, P, Pashayan, N, Khaw, K-T, Stanford, JL, Thibodeau, SN, McDonnell, SK, Schaid, DJ, Maier, C, Vogel, W, Luedeke, M, Herkommer, K, Kibel, AS, Cybulski, C, Wokolorczyk, D, Kluzniak, W, Cannon-Albright, L, Teerlink, C, Brenner, H, Dieffenbach, AK, Arndt, V, Park, JY, Sellers, TA, Lin, H-Y, Slavov, C, Kaneva, R, Mitev, V, Batra, J, Spurdle, A, Clements, JA, Teixeira, MR, Pandha, HS, Michael, A, Paulo, P, Maia, S, Kierzek, A, Conti, DV, Albanes, D, Berg, C, Berndt, SI, Campa, D, Crawford, ED, Diver, WR, Gapstur, SM, Gaziano, JM, Giovannucci, E, Hoover, R, Hunter, DJ, Johansson, M, Kraft, P, Le Marchand, L, Lindstrom, S, Navarro, C, Overvad, K, Riboli, E, Siddiq, A, Stevens, VL, Trichopoulos, D, Vineis, P, Yeager, M, Trynka, G, Raychaudhuri, S, Schumacher, FR, Price, AL, Freedman, ML, Haiman, CA, Pasaniuc, B, Cook, M, Guy, M, Govindasami, K, Leongamornlert, D, Sawyer, EJ, Wilkinson, R, Saunders, EJ, Tymrakiewicz, M, Dadaev, T, Morgan, A, Fischer, C, Hazel, S, Livni, N, Lophatananon, A, Pedersen, J, Hopper, JL, Adolfson, J, Stattin, P, Johansson, J-E, Cavalli-Bjoerkman, C, Karlsson, A, Broms, M, Auvinen, A, Kujala, P, Maeaettaenen, L, Murtola, T, Taari, K, Weischer, M, Nielsen, SF, Klarskov, P, Roder, A, Iversen, P, Wallinder, H, Tillmans, L, Riska, S, Wang, L, Rinckleb, A, Lubiski, J, Stegmaier, C, Pow-Sang, J, Park, H, Radlein, S, Rincon, M, Haley, J, Zachariah, B, Kachakova, D, Popov, E, Mitkova, A, Vlahova, A, Dikov, T, Christova, S, Heathcote, P, Wood, G, Malone, G, Saunders, K, Eckert, A, Yeadon, T, Kerr, K, Collins, A, Turner, M, Srinivasan, S, Kedda, M-A, Alexander, K, Omara, T, Wu, H, Henrique, R, Pinto, P, Santos, J, Barros-Silva, J

Publikováno v: Gusev, A, Shi, H, Kichaev, G, Pomerantz, M, Li, F, Long, H W, Ingles, S A, Kittles, R A, Strom, S S, Rybicki, B A, Nemesure, B, Isaacs, W B, Zheng, W, Pettaway, C A, Yeboah, E D, Tettey, Y, Biritwum, R B, Adjei, A A, Tay, E, Truelove, A, Niwa, S, Chokkalingam, A P, John, E M, Murphy, A B, Signorello, L B, Carpten, J, Leske, M C, Wu, S-Y, Hennis, A J M, Neslund-Dudas, C, Hsing, A W, Chu, L, Goodman, P J, Klein, E A, Witte, J S, Casey, G, Kaggwa, S, Cook, M B, Stram, D O, Blot, W J, Eeles, R A, Easton, D, Kote-Jarai, ZS, Al Olama, A A, Benlloch, S, Muir, K, Giles, G G, Southey, M C, Fitzgerald, L M, Overvad, K & PRACTICAL consortium 2016, ' Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation ', Nature Communications, vol. 7, pp. 10979 . https://doi.org/10.1038/ncomms10979
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Gusev, A, Shi, H, Kichaev, G, Pomerantz, M, Li, F, Long, H W, Ingles, S A, Kittles, R A, Strom, S S, Rybicki, B A, Nemesure, B, Isaacs, W B, Zheng, W, Pettaway, C A, Yeboah, E D, Tettey, Y, Biritwum, R B, Adjei, A A, Tay, E, Truelove, A, Niwa, S, Chokkalingam, A P, John, E M, Murphy, A B, Signorello, L B, Carpten, J, Leske, M C, Wu, S-Y, Hennis, A J M, Neslund-Dudas, C, Hsing, A W, Chu, L, Goodman, P J, Klein, E A, Witte, J S, Casey, G, Kaggwa, S, Cook, M B, Stram, D O, Blot, W J, Eeles, R A, Easton, D, Kote-Jarai, ZS, Al Olama, A A, Benlloch, S, Muir, K, Giles, G G, Southey, M C, Fitzgerald, L M, Raychaudhuri, S & PRACTICAL Consortium 2016, ' Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation ', Nature Communications, vol. 7, 10979 . https://doi.org/10.1038/ncomms10979
Gusev, A, Shi, H, Kichaev, G, Pomerantz, M, Li, F, Long, H W, Ingles, S A, Kittles, R A, Strom, S S, Rybicki, B A, Nemesure, B, Isaacs, W B, Zheng, W, Pettaway, C A, Yeboah, E D, Tettey, Y, Biritwum, R B, Adjei, A A, Tay, E, Truelove, A, Niwa, S, Chokkalingam, A P, John, E M, Murphy, A B, Signorello, L B, Carpten, J, Leske, M C, Wu, S Y, Hennis, A J M, Neslund-Dudas, C, Hsing, A W, Chu, L, Goodman, P J, Klein, E A, Witte, J S, Casey, G, Kaggwa, S, Cook, M B, Stram, D O, Blot, W J, Eeles, R A, Easton, D, Kote-Jarai, Z, Al Olama, A A, Benlloch, S, Muir, K, Giles, G G, Southey, M C, Fitzgerald, L M, Gronberg, H, Wiklund, F, Aly, M, Henderson, B E, Schleutker, J, Wahlfors, T, Tammela, T L J, Nordestgaard, B G, Key, T J, Travis, R C, Neal, D E, Donovan, J L, Hamdy, F C, Pharoah, P, Pashayan, N, Khaw, K T, Stanford, J L, Thibodeau, S N, McDonnell, S K, Schaid, D J, Maier, C, Vogel, W, Luedeke, M, Herkommer, K, Kibel, A S, Cybulski, C, Wokolorczyk, D, Kluzniak, W, Cannon-Albright, L, Teerlink, C, Brenner, H, Dieffenbach, A K, Arndt, V, Park, J Y, Sellers, T A, Lin, H Y, Slavov, C, Kaneva, R, Mitev, V, Batra, J, Spurdle, A, Clements, J A, Teixeira, M R, Pandha, H, Michael, A, Paulo, P, Maia, S, Kierzek, A, Conti, D V, Albanes, D, Berg, C, Berndt, S I, Campa, D, Crawford, E D, Diver, W R, Gapstur, S M, Gaziano, J M, Giovannucci, E, Hoover, R, Hunter, D J, Johansson, M, Kraft, P, Le Marchand, L, Lindström, S, Navarro, C, Overvad, K, Riboli, E, Siddiq, A, Stevens, V L, Trichopoulos, D, Vineis, P, Yeager, M, Trynka, G, Raychaudhuri, S, Schumacher, F R, Price, A L, Freedman, M L, Haiman, C A & Pasaniuc, B 2016, ' Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation ', Nature Communications, vol. 7, 10979 . https://doi.org/10.1038/ncomms10979

Although genome-wide association studies have identified over 100 risk loci that explain ∼33% of familial risk for prostate cancer (PrCa), their functional effects on risk remain largely unknown. Here we use genotype data from 59,089 men of Europea

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http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-122103

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