Genetic Disruption of Circadian Rhythms in the Suprachiasmatic Nucleus Causes Helplessness, Behavioral Despair, and Anxiety-like Behavior in Mice

Autor: Landgraf, D, Long, JE, Proulx, CD, Barandas, R, Malinow, R, Welsh, DK

Publikováno v: Biological psychiatry, vol 80, iss 11
Landgraf, D; Long, JE; Proulx, CD; Barandas, R; Malinow, R; & Welsh, DK. (2016). Genetic Disruption of Circadian Rhythms in the Suprachiasmatic Nucleus Causes Helplessness, Behavioral Despair, and Anxiety-like Behavior in Mice. BIOLOGICAL PSYCHIATRY, 80(11), 827-835. doi: 10.1016/j.biopsych.2016.03.1050. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/5z41x0p3

BackgroundMajor depressive disorder is associated with disturbed circadian rhythms. To investigate the causal relationship between mood disorders and circadian clock disruption, previous studies in animal models have employed light/dark manipulations

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::1bc83d129f07f4ef52536f16e3419f9c
https://escholarship.org/uc/item/5z41x0p3

Synthesis and study ofN,N‐disubstituted 4‐[(4‐aminophenyl)diazenyl]benzylidene‐4′‐alkylanilines

Autor: Long-Li Lai, Yang-Chu Lin, Chun-Ming Yang, Kung-Lung Cheng, Long-Je Lee, Ling-Yung Wang, Woan-shiow Tzeng, Chih‐Lin Su

Publikováno v: Liquid Crystals. 33:289-293

A series of N,N‐disubstituted‐4‐[(4‐aminophenyl)diazenyl]benzylidene‐4′‐alkylanilines (azo dyes) were synthesized from the reaction of the corresponding benzaldehyde with alkylanilines. These azo dyes exhibit nematic and SmC phases on h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e0578b79cbb131b68f094f567223d01e
https://doi.org/10.1080/02678290500242064

Study of the mesogenic behaviour of hydrogen-bonded complexes prepared from aminophenylazopyridines and benzoic acid derivatives

Autor: Feng-Ya Su, Long-Li Lai, Eshin Wang, Long-Je Lee

Publikováno v: Liquid Crystals. 28:381-386

Complexes have been formed between N, N-disubstituted aminophenylazopyridines and a series of alkoxybenzoic acids by intermolecular hydrogen bonding; liquid crystalline phases of the resulting complexes are induced thereby.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6f9a583aab4ee5c0a852c11fdefe2953
https://doi.org/10.1080/02678290010013957

Loss of Gsx1 and Gsx2 function rescues distinct phenotypes in Dlx1/2 mutants

Autor: Rubenstein, John, Wang, B, Long, JE, Flandin, P, Pla, R, Waclaw, RR, Campbell, K, Rubenstein, JLR

Publikováno v: Rubenstein, John; Wang, B; Long, JE; Flandin, P; Pla, R; Waclaw, RR; et al.(2013). Loss of Gsx1 and Gsx2 function rescues distinct phenotypes in Dlx1/2 mutants. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/6kz945qb

Mice lacking the Dlx1 and Dlx2 homeobox genes (Dlx1/2 mutants) have severe deficits in subpallial differentiation, including overexpression of the Gsx1 and Gsx2 homeobox genes. To investigate whether Gsx overexpression contributes to the Dlx1/2 mutan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::e63034d39bdc8951ec9300fa0aa7263a
http://www.escholarship.org/uc/item/6kz945qb

New stack gate insulator structure strongly reduces FIBL effect

Autor: Chen-Hsiao Lai, Hai-Ming Lee, Long-Je Do, Ya-Chin King, Ling-Chang Hu

Publikováno v: 2001 International Symposium on VLSI Technology, Systems, and Applications. Proceedings of Technical Papers (Cat. No.01TH8517).

Recent studies have shown that by adapting high-k gate dielectric, deep sub-micron MOSFET suffers short channel effect caused by the fringing electric fields from gate to source/drain regions. In this work, a simulation-based analysis of multiple gat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::55126d5f177ffbc70b1d87ff9911a3b5
https://doi.org/10.1109/vtsa.2001.934523