Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Lone Pridal"'
Autor:
Frantisek Hubálek, Hanne H. F. Refsgaard, Sanne Gram-Nielsen, Peter Madsen, Erica Nishimura, Martin Münzel, Christian Lehn Brand, Carsten Enggaard Stidsen, Christian Hove Claussen, Erik Max Wulff, Lone Pridal, Ulla Ribel, Jonas Kildegaard, Trine Porsgaard, Eva Johansson, Dorte Bjerre Steensgaard, Lars Hovgaard, Tine Glendorf, Bo Falck Hansen, Maja Kirkegaard Jensen, Peter Kresten Nielsen, Svend Ludvigsen, Susanne Rugh, Patrick W. Garibay, Mary Courtney Moore, Alan D. Cherrington, Thomas Kjeldsen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Recently, the first orally-administered ultra-long acting insulin was shown to have clinical efficacy. Here, the authors report the molecular engineering, as well as the biological and pharmacological properties of these insulin analogues.
Externí odkaz:
https://doaj.org/article/b3637544155945e480839f9c67516402
Autor:
Erica Nishimura, Lone Pridal, Tine Glendorf, Bo Falk Hansen, František Hubálek, Thomas Kjeldsen, Niels Rode Kristensen, Anne Lützen, Karsten Lyby, Peter Madsen, Thomas Åskov Pedersen, Rasmus Ribel-Madsen, Carsten Enggaard Stidsen, Hanne Haahr
Publikováno v:
BMJ Open Diabetes Research & Care, Vol 9, Iss 1 (2021)
Introduction Insulin icodec is a novel, long-acting insulin analog designed to cover basal insulin requirements with once-weekly subcutaneous administration. Here we describe the molecular engineering and the biological and pharmacological properties
Externí odkaz:
https://doaj.org/article/75bb0be2610749feb0124a6abfc40035
Autor:
Frantisek Hubálek, Hanne H. F. Refsgaard, Sanne Gram-Nielsen, Peter Madsen, Erica Nishimura, Martin Münzel, Christian Lehn Brand, Carsten Enggaard Stidsen, Christian Hove Claussen, Erik Max Wulff, Lone Pridal, Ulla Ribel, Jonas Kildegaard, Trine Porsgaard, Eva Johansson, Dorte Bjerre Steensgaard, Lars Hovgaard, Tine Glendorf, Bo Falck Hansen, Maja Kirkegaard Jensen, Peter Kresten Nielsen, Svend Ludvigsen, Susanne Rugh, Patrick W. Garibay, Mary Courtney Moore, Alan D. Cherrington, Thomas Kjeldsen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/f3cf07c418ea4af69c46d62c9eb076b7
Autor:
Tina M. Tagmose, Karen-Margrethe Pedersen, Lone Pridal, Carsten E. Stidsen, Marie Ø. Pedersen, Zhaosheng Lin, Yuanyuan Zhang, Zhe Wan, Mercedes Ferreras, Helle Naver, Peter K. Nielsen, Zheng Cao, Yi Wang, Lennart Lykke, Josefine L. Christensen, Victoria S. Jensen, Valentina Manfè, Thomas Å. Pedersen, Eva Johansson, Peter Madsen, János T. Kodra, Martin Münzel, Leonardo De Maria, Erica Nishimura, Thomas B. Kjeldsen
Publikováno v:
Journal of Medicinal Chemistry. 65:2633-2645
Here, we describe molecular engineering of monovalent ultra-long acting two-chain insulin-Fc conjugates. Insulin-Fc conjugates were synthesized using trifunctional linkers with one amino reactive group for reaction with a lysine residue of insulin an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b517e3f0eea1d2de015b33913626c34
https://doi.org/10.1021/acs.jmedchem.1c02039
https://doi.org/10.1021/acs.jmedchem.1c02039
Autor:
Ulrike Hövelmann, Erica Nishimura, Thomas Kjeldsen, Frantisek Hubalek, Tine Glendorf, Carsten E. Stidsen, Bo F. Hansen, Thomas A. Pedersen, Anne Lützen, Lone Pridal, Peter Madsen
Publikováno v:
Hand in Hand zum Ziel – einfach.besser.messbar www.diabeteskongress.de.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df180a7a304f2f39d265b4c60a4d173b
https://doi.org/10.1055/s-0042-1746280
https://doi.org/10.1055/s-0042-1746280
Autor:
Erik M. Wulff, Patrick William Garibay, Eva Johansson, Martin Münzel, Tine Glendorf, Erica Nishimura, Bo Falck Hansen, Thomas Kjeldsen, Peter Madsen, Christian L. Brand, Sanne Gram-Nielsen, Trine Porsgaard, Hanne H. F. Refsgaard, Frantisek Hubalek, Svend Ludvigsen, Dorte Bjerre Steensgaard, Lars Hovgaard, Carsten Enggaard Stidsen, Susanne Rugh, Jonas Kildegaard, Lone Pridal, Maja Jensen, Christian Hove Claussen, Ulla Ribel, Alan D. Cherrington, Mary Courtney Moore, Peter Kresten Nielsen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Nature Communications
Nature Communications
Recently, the clinical proof of concept for the first ultra-long oral insulin was reported, showing efficacy and safety similar to subcutaneously administered insulin glargine. Here, we report the molecular engineering as well as biological and pharm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::113155943c2b6a189cde64bb824cd5b9
https://doaj.org/article/b3637544155945e480839f9c67516402
https://doaj.org/article/b3637544155945e480839f9c67516402
Autor:
Peter Madsen, Thomas Kjeldsen, Claus Bekker Jeppesen, Hanne H. F. Refsgaard, Trine Porsgaard, Helle Naver, Sanne Gram-Nielsen, Frantisek Hubalek, Lone Pridal, Tina Møller Tagmose, Erica Nishimura, Inger Lautrup-Larsen, Carsten Enggaard Stidsen, Valentina Manfè, Thomas Hoeg-Jensen, Claudia Ulrich Hjørringgaard, Svend Ludvigsen, Christian Fledelius
Publikováno v:
Journal of medicinal chemistry. 64(13)
Here, we describe the molecular engineering of insulin icodec to achieve a plasma half-life of 196 h in humans, suitable for once-weekly subcutaneously administration. Insulin icodec is based on re-engineering of the ultra-long oral basal insulin OI3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09bbecdf553cdca0c9ff44818b4017bb
https://pubmed.ncbi.nlm.nih.gov/33944562
https://pubmed.ncbi.nlm.nih.gov/33944562
Autor:
Hanne Haahr, Carsten Enggaard Stidsen, Rasmus Ribel-Madsen, Anne Lützen, Thomas Åskov Pedersen, Karsten Lyby, Lone Pridal, Thomas Kjeldsen, Peter Madsen, Frantisek Hubalek, Bo Falk Hansen, Erica Nishimura, Niels Rode Kristensen, Tine Glendorf
Publikováno v:
BMJ Open Diabetes Research & Care
BMJ Open Diabetes Research & Care, Vol 9, Iss 1 (2021)
BMJ Open Diabetes Research & Care, Vol 9, Iss 1 (2021)
IntroductionInsulin icodec is a novel, long-acting insulin analog designed to cover basal insulin requirements with once-weekly subcutaneous administration. Here we describe the molecular engineering and the biological and pharmacological properties
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::759dbb38cb97c67986c9ef3b1c415879
https://pubmed.ncbi.nlm.nih.gov/34413118
https://pubmed.ncbi.nlm.nih.gov/34413118
Autor:
Ulla Ribel, Erik M. Wulff, Alan D. Cherrington, Peter Kresten Nielsen, Martin Münzel, Thomas Kjeldsen, Svend Ludvigsen, Frantisek Hubalek, Lars Hovgaard, Christian Hove Claussen, Jonas Kildegaard, Maja Jensen, Lone Pridal, Hanne H. F. Refsgaard, Patrick William Garibay, Mary Courtney Moore, Sanne Gram-Nielsen, Erica Nishimura, Dorte Bjerre Steensgaard, Carsten Enggaard Stidsen, Tine Glendorf, Peter Madsen, Susanne Rugh, Bo Falck Hansen, Eva Johansson, Christian L. Brand, Trine Porsgaard
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6582242c3083f360c87f02dd8695f95
http://europepmc.org/articles/PMC7441397
http://europepmc.org/articles/PMC7441397
Autor:
Erica Nishimura, Bo Falck Hansen, Anne Luetzen, Thomas Åskov Pedersen, Thomas Kjeldsen, Carsten Enggaard Stidsen, Peter Madsen, Lone Pridal, Frantisek Hubalek, Tine Glendorf
Publikováno v:
Diabetes. 69
Insulin icodec is a novel insulin analog with a terminal elimination half-life of ∼196 hours currently in clinical development, designed to be able to cover a full week’s basal insulin requirements with a single subcutaneous injection. To attain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::044a64a6b69dff520981c9203214b215
https://doi.org/10.2337/db20-236-or
https://doi.org/10.2337/db20-236-or