Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Lone Lindal Hansen"'
Publikováno v:
Madsen, H, Enggaard, T P, Hansen, L L, Klitgaard, N A & Brøsen, K 2001, ' Fluvoxamine inhibits the CYP2C9 catalyzed biotransformation of tolbutamide ', Clinical Pharmacology and Therapeutics, vol. 69, no. 1, pp. 41-47 . https://doi.org/10.1067/mcp.2001.112689
Objective Our objective was to examine the interaction between fluvoxamine and tolbutamide to confirm that fluvoxamine inhibits CYP2C9. Methods The study was carried out as an open, randomized, crossover design with 14 healthy participants. In period
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9a35de89bd46b74c98932f13a944c16
https://doi.org/10.1067/mcp.2001.112689
https://doi.org/10.1067/mcp.2001.112689
Publikováno v:
British Journal of Clinical Pharmacology. 48:829-838
Aims In vitro studies suggest that the oxidation of quinidine to 3-hydroxyquinidine is a specific marker reaction for CYP3A4 activity. To assess the possible use of this reaction as an in vivo marker of CYP3A4 activity, we studied the involvement of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0165b4ac5de11a08be45e738c411c1d
https://doi.org/10.1046/j.1365-2125.1999.00099.x
https://doi.org/10.1046/j.1365-2125.1999.00099.x
Publikováno v:
British Journal of Clinical Pharmacology. 48:663-668
Aims The aim of the present study was to examine the CYP1A2 substrate tacrine as a possible alternative to caffeine for assessing CYP1A2 activity in vivo. Methods Eighteen, healthy, nonsmoking men participated. Each volunteer was tested by caffeine (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68455240a4fddd25384ac544baa5c30e
https://doi.org/10.1046/j.1365-2125.1999.00079.x
https://doi.org/10.1046/j.1365-2125.1999.00079.x
Publikováno v:
Pharmacology & Toxicology. 85:257-262
We investigated the effect of cytochrome P450 induction by rifampicin on the in vivo oxidative metabolism of quinidine. The pharmacokinetics of a 200 mg oral single dose quinidine were studied before and after one week of daily treatment with 600 mg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4057e1a7058b8fccd4dc716e1ae7154c
https://doi.org/10.1111/j.1600-0773.1999.tb02019.x
https://doi.org/10.1111/j.1600-0773.1999.tb02019.x
Autor:
Kim Brøsen, Lone Lindal Hansen
Publikováno v:
Therapeutic drug monitoring. 21(6)
An isocratic, high-performance liquid chromatography method has been developed for simultaneous determination of the oral antidiabetic tolbutamide and two of its metabolites, 4-hydroxytolbutamide and carboxytolbutamide, in human plasma and urine. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6c5312022305c53241826a244f6b460
https://pubmed.ncbi.nlm.nih.gov/10604830
https://pubmed.ncbi.nlm.nih.gov/10604830
Publikováno v:
Lindal Hansen, L, Teilmann Larsen, J & Brøsen, K 1998, ' Determination of tacrine and its metabolites in human plasma and urine by high-performance liquid chromatography and fluorescence detection ', Journal of Chromatography B: Biomedical Sciences and Applications, vol. 712, no. 1-2, pp. 183-191 . https://doi.org/10.1016/S0378-4347(98)00183-2
A new method for the simultaneous quantitation of tacrine and the three metabolites, 1-hydroxytacrine (velnacrine, maleate), 2-hydroxytacrine and 4-hydroxytacrine, in human plasma and urine has been developed. The method was based on simple one-step
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70a003fc5531da00730b7dbad1c5716d
https://portal.findresearcher.sdu.dk/da/publications/6901fed0-6ca1-48a1-8996-8960d1b542b6
https://portal.findresearcher.sdu.dk/da/publications/6901fed0-6ca1-48a1-8996-8960d1b542b6
Publikováno v:
University of Southern Denmark
Damkier, P, Hansen, L L & Brøsen, K 1999, ' Effect of fluvoxamine on the pharmacokinetics of quinidine ', European Journal of Clinical Pharmacology, vol. 55, pp. 451-56 .
Damkier, P, Hansen, L L & Brøsen, K 1999, ' Effect of fluvoxamine on the pharmacokinetics of quinidine ', European Journal of Clinical Pharmacology, vol. 55, pp. 451-56 .
Objective: To investigate the possible involvement of cytochromes CYP1A2 and CYP2C19 in the in vivo oxidative metabolism of quinidine. Methods: This was an open study of six healthy young male volunteers. The pharmacokinetics of a 200-mg single oral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7d4dc9a1795a905f17ee899883563a0
https://portal.findresearcher.sdu.dk/en/publications/a9f55d50-ba97-11dc-9626-000ea68e967b
https://portal.findresearcher.sdu.dk/en/publications/a9f55d50-ba97-11dc-9626-000ea68e967b