Zobrazeno 1 - 10
of 500
pro vyhledávání: '"Lonafarnib"'
Publikováno v:
Журнал инфектологии, Vol 16, Iss 3, Pp 24-35 (2024)
Viral hepatitis D (HDV infection) worsens the prognosis of HBV infection course in 80-90% of cases, accelerating fibrosis and leading to liver cirrhosis or hepatocellular carcinoma. Hepatitis D affects at least 125 000 people in Russia, and in the wo
Externí odkaz:
https://doaj.org/article/dbbae6dd4e2649119022b6863a782fe1
Akademický článek
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Publikováno v:
Drug Design, Development and Therapy, Vol Volume 17, Pp 155-166 (2023)
Vicente Soriano,1 Victor Moreno-Torres,1,2 Ana Treviño,1 Octavio Corral,1 Carmen de Mendoza2 1Health Sciences School & Medical Center, Universidad Internacional La Rioja (UNIR), Madrid, Spain; 2Puerta de Hierro University Hospital & Research Institu
Externí odkaz:
https://doaj.org/article/6343663458f1420eb7b5b0e7e567e362
Autor:
Sae-Il Murtada, Nicole Mikush, Mo Wang, Pengwei Ren, Yuki Kawamura, Abhay B Ramachandra, David S Li, Demetrios T Braddock, George Tellides, Leslie B Gordon, Jay D Humphrey
Publikováno v:
eLife, Vol 12 (2023)
Clinical trials have demonstrated that lonafarnib, a farnesyltransferase inhibitor, extends the lifespan in patients afflicted by Hutchinson-Gilford progeria syndrome, a devastating condition that accelerates many characteristics of aging and results
Externí odkaz:
https://doaj.org/article/f044f7f1664a46e8b1fa8ef58ff4d93a
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
IntroductionHyperphosphorylated Tau formed neurofibrillary tangles was one of the major neuropathological hallmarks of Alzheimer’s disease (AD). Dysfunctional insulin signaling in brain is involved in AD. However, the effect of Tau pathology on bra
Externí odkaz:
https://doaj.org/article/b951860a55c14b37bf6876db71658b44
Akademický článek
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Autor:
Sandmann L, Cornberg M
Publikováno v:
Journal of Experimental Pharmacology, Vol Volume 13, Pp 461-468 (2021)
Lisa Sandmann,1 Markus Cornberg1,2 1Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany; 2Centre for Individualised Infection Medicine (CiiM), Helmholtz Centre for Infection Research, Braunschweig,
Externí odkaz:
https://doaj.org/article/bbd42fae79fd4b9eb93ebc37b6bf0405
Publikováno v:
Cells, Vol 12, Iss 10, p 1350 (2023)
Hutchinson–Gilford progeria syndrome (HGPS) is a rare genetic disease that causes premature aging symptoms, such as vascular diseases, lipodystrophy, loss of bone mineral density, and alopecia. HGPS is mostly linked to a heterozygous and de novo mu
Externí odkaz:
https://doaj.org/article/e3724645a7124f78914ec85e8119eb8e
Publikováno v:
Остеопороз и остеопатии, Vol 22, Iss 3, Pp 4-18 (2020)
Aging is a multi-factor biological process that inevitably affects everyone. Degenerative processes, starting at the cellular and molecular levels, gradually influence the change in the functional capabilities of all organs and systems. Progeroid syn
Externí odkaz:
https://doaj.org/article/275bd24db92a45c8a07abb3ce9ee21a9
Autor:
Linke Huang, Weiwei Chen, Linhua Wei, Yuangang Su, Jiamin Liang, Haoyu Lian, Hui Wang, Feng Long, Fan Yang, Shiyao Gao, Zhen Tan, Jiake Xu, Jinmin Zhao, Qian Liu
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Wear debris after total joint arthroplasty can attract the recruitment of macrophages, which release pro-inflammatory substances, triggering the activation of osteoclasts, thereby leading to periprosthetic osteolysis (PPOL) and aseptic loosening. How
Externí odkaz:
https://doaj.org/article/e7829e3de56a4c9fb35005ef4a703458