Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Lona Poole"'
Autor:
Charles Bradley, Lona Poole, Robert Leong, Anatole Besarab, Liubov Eremeeva, Lynda A. Szczech, Meraf Eyassu, Thomas B. Neff, Kin-Hung Peony Yu, Evgeny Shutov, Cameron Liu, Robert Provenzano, Gopal Saha, Svitlana Korneyeva
Publikováno v:
Nephrology Dialysis Transplantation. 36:1717-1730
Background We evaluated the efficacy and safety of roxadustat versus epoetin alfa for the treatment of chronic kidney disease-related anemia in patients new to dialysis. Methods HIMALAYAS was a Phase 3, open-label, epoetin alfa-controlled trial. Elig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfb75680793426ec819f4ff73c2ac112
https://doi.org/10.1093/ndt/gfab051
https://doi.org/10.1093/ndt/gfab051
Autor:
Gopal Saha, Sohan Dua, Khalil G. Saikali, Robert Provenzano, Lynda A. Szczech, Steven Zeig, Peter Nguyen, Steven Wright, Lona Poole, Stefan Hemmerich, Anatole Besarab, Thomas B. Neff, K. H. Peony Yu
Publikováno v:
American Journal of Kidney Diseases. 67:912-924
BackgroundRoxadustat (FG-4592) is an oral hypoxia-inducible factor prolyl-hydroxylase inhibitor that promotes erythropoiesis through increasing endogenous erythropoietin, improving iron regulation, and reducing hepcidin.Study DesignPhase 2, randomize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21ad1af4b193c6a24669722b39cb3dfa
https://doi.org/10.1053/j.ajkd.2015.12.020
https://doi.org/10.1053/j.ajkd.2015.12.020
Autor:
Marietta Franco, Lalathaksha Kumbar, Ming Zhong, Lona Poole, Evgeny Shutov, Khalil G. Saikali, Robert Leong, Anatole Besarab, Daniel Tak Mao Chan, Kin-Hung Peony Yu, Elena Chernyavskaya, Stefan Hemmerich, Konstantin Gurevich, Thomas B. Neff, Igor Motylev
Safety concerns with erythropoietin analogues and intravenous (IV) iron for treatment of anemia in CKD necessitate development of safer therapies. Roxadustat (FG-4592) is an orally bioavailable hypoxia-inducible factor (HIF) prolyl hydroxylase inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2438ab23bdde48ef33c0421a581d0f08
https://europepmc.org/articles/PMC4814189/
https://europepmc.org/articles/PMC4814189/
Autor:
John Constant, Randy Allred, Steven B. Porter, Stanley A. Nasraway, Robert N. Cooney, R. Bruce Light, Guillermo Gutierrez, Howard Levy, Anthony R. Dal Nogare, Robert P. Baughman, Mark J. Rumbak, Edward Abraham, Richard G. Wunderink, Lona Poole, Sidney Tessler, Gerry San Pedro, James E Pennington, Steve Berman, Antonio Anzueto
Publikováno v:
The Lancet. 351:929-933
Summary Background Despite the availability of potent antibiotics and intensive care, mortality rates from septic shock are 40–70%. We assessed the safety and efficacy of murine monoclonal antibody to human tumour necrosis factor α (TNF α MAb) in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c53d8e2f87edcc9099e3a664bfdcbe7
https://doi.org/10.1016/s0140-6736(05)60602-2
https://doi.org/10.1016/s0140-6736(05)60602-2
Autor:
Abla A. Creasey, Fang Xie, Richard G. Wunderink, Steven P. LaRosa, Steven M. Opal, Edward Abraham, Pierre-François Laterre, Lona Poole
Publikováno v:
Critical care (London, England), Vol. 13, no. 2, p. R36 (2009)
Critical Care
Critical Care
INTRODUCTION: The purpose of this analysis was to determine the potential efficacy of recombinant human tissue factor pathway inhibitor (tifacogin) in a subpopulation of patients with community-acquired pneumonia (CAP) from a phase III study of sever
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c608d5fd2ca61f96bc84f9ced873e0f
https://hdl.handle.net/2078.1/26294
https://hdl.handle.net/2078.1/26294
Autor:
Claus Peckelsen, James C. Stolzenbach, Ville Pettilä, Vincent Shu, Stuart Simon, Abla A. Creasey, Christopher J. Doig, Edward Abraham, Russell Postier, Bruce Light, Konrad Reinhart, Judy Stone, Herbert Spapen, Charles L. Sprung, Petr Svoboda, Lona Poole, Jeffrey Tobias, Sandra Percell, Steven M. Opal, Ignace Demeyer, Cathy De Deyne, Allan Seibert, Christian Zwingelstein, Antonio Artigas, Pierre-François Laterre, Angel López Rodriguez, Richard Beale
Publikováno v:
JAMA. 290(2)
Context The expression and release of tissue factor is a major trigger for the activation of coagulation in patients with sepsis. Tissue factor pathway inhibitor (TFPI) forms a complex with tissue factor and blood protease factors leading to inhibiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aa3ec05bc299e6b9e5c9b054ef61ede
https://pubmed.ncbi.nlm.nih.gov/12851282
https://pubmed.ncbi.nlm.nih.gov/12851282
Publikováno v:
Chest. 128:151S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7bb0e876a50a64fd76fe0767431ff2f6
https://doi.org/10.1378/chest.128.4_meetingabstracts.151s-a
https://doi.org/10.1378/chest.128.4_meetingabstracts.151s-a