Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Lona M Alkhalaf"'
Autor:
Chuan Huang, Daniel Zabala, Emmanuel L C de los Santos, Lijiang Song, Christophe Corre, Lona M Alkhalaf, Gregory L Challis
Publikováno v:
Nucleic Acids Research. 51:1488-1499
Advances in DNA sequencing technology and bioinformatics have revealed the enormous potential of microbes to produce structurally complex specialized metabolites with diverse uses in medicine and agriculture. However, these molecules typically requir
Publikováno v:
Chembiochem
Aromatic nitration reactions are a cornerstone of organic chemistry, but are challenging to scale due to corrosive reagents and elevated temperatures. The cytochrome P450 TxtE nitrates the indole 4‐position of l‐tryptophan at room temperature usi
Autor:
Max J. Cryle, Christophe Corre, Vilmos Fülöp, Peter J. Harrison, Hussain Bhukya, Dean Rea, Paulina K. Sydor, Shanshan Zhou, Kathryn M Styles, Nicolas Malet, Lona M. Alkhalaf, Matthew J. Belousoff, Gregory L. Challis, Hariprasad Venugopal, Lijiang Song
Actinobacteria produce numerous antibiotics and other specialized metabolites that have important applications in medicine and agriculture1. Diffusible hormones frequently control the production of such metabolites by binding TetR family transcriptio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41246cf510233073e62d4fc01a9c5fe6
http://wrap.warwick.ac.uk/148309/1/WRAP-Molecular-basis-control-antibiotic-production-bacterial-hormone-2021.pdf
http://wrap.warwick.ac.uk/148309/1/WRAP-Molecular-basis-control-antibiotic-production-bacterial-hormone-2021.pdf
Autor:
Lona M. Alkhalaf, Andrew W. Munro, Sarah M. Barry, Hafiz Saqib Ali, M. Qadri E. Mubarak, Sam P. de Visser, Nigel S. Scrutton, Savvas Louka, Gregory L. Challis, Derren J. Heyes
Publikováno v:
Journal of the American Chemical Society
Louka, S, Barry, S M, Heyes, D J, Mubarak, M Q E, Ali, H S, Alkhalaf, L M, Munro, A W, Scrutton, N S, Challis, G L & de Visser, S P 2020, ' Catalytic Mechanism of Aromatic Nitration by Cytochrome P450 TxtE : Involvement of a Ferric-Peroxynitrite Intermediate ', Journal of the American Chemical Society, vol. 142, no. 37, pp. 15764-15779 . https://doi.org/10.1021/jacs.0c05070
Louka, S, Barry, S M, Heyes, D J, Mubarak, M Q E, Ali, H S, Alkhalaf, L M, Munro, A W, Scrutton, N S, Challis, G L & de Visser, S P 2020, ' Catalytic Mechanism of Aromatic Nitration by Cytochrome P450 TxtE : Involvement of a Ferric-Peroxynitrite Intermediate ', Journal of the American Chemical Society, vol. 142, no. 37, pp. 15764-15779 . https://doi.org/10.1021/jacs.0c05070
The cytochromes P450 are heme-dependent enzymes that catalyze many vital reaction processes in the human body related to biodegradation and biosynthesis. They typically act as mono-oxygenases; however, the recently discovered P450 subfamily TxtE util
Autor:
Shanshan Zhou, Hussain Bhukya, Nicolas Malet, Peter J. Harrison, Dean Rea, Matthew J. Belousoff, Hariprasad Venugopal, Paulina K. Sydor, Kathryn M. Styles, Lijiang Song, Max J. Cryle, Lona M. Alkhalaf, Vilmos Fülöp, Gregory L. Challis, Christophe Corre
SummaryActinobacteria produce numerous antibiotics and other specialised metabolites with important applications in medicine and agriculture. Diffusible hormones frequently control the production of such metabolites by binding TetR family transcripti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54014946155f01580f0d3499ba07f27f
Autor:
Shanshan, Zhou, Hussain, Bhukya, Nicolas, Malet, Peter J, Harrison, Dean, Rea, Matthew J, Belousoff, Hariprasad, Venugopal, Paulina K, Sydor, Kathryn M, Styles, Lijiang, Song, Max J, Cryle, Lona M, Alkhalaf, Vilmos, Fülöp, Gregory L, Challis, Christophe, Corre
Publikováno v:
Nature. 590(7846)
Actinobacteria produce numerous antibiotics and other specialized metabolites that have important applications in medicine and agriculture
Autor:
Lona M. Alkhalaf, Gregory L. Challis, Vilmos Fülöp, Sarah M. Barry, Daniel Griffiths, Angelo Gallo, Dean Rea, Józef R. Lewandowski
Publikováno v:
Alkhalaf, L M, Barry, S M, Rea, D, Gallo, A, Griffiths, D, Lewandowski, J R, Fulop, V & Challis, G L 2019, ' Binding of Distinct Substrate Conformations Enables Hydroxylation of Remote Sites in Thaxtomin D by Cytochrome P450 TxtC ', Journal of the American Chemical Society, vol. 141, no. 1, pp. 216-222 . https://doi.org/10.1021/jacs.8b08864
Cytochromes P450 (CYPs) catalyze various oxidative transformations in drug metabolism, xenobiotic degradation, and natural product biosynthesis. Here we report biochemical, structural, and theoretical studies of TxtC, an unusual bifunctional CYP invo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49d43605c75e3e9b2e2d5fb770da5d45
https://kclpure.kcl.ac.uk/en/publications/16f4c41d-b4d0-4016-82dd-b53b541b9e2f
https://kclpure.kcl.ac.uk/en/publications/16f4c41d-b4d0-4016-82dd-b53b541b9e2f
Autor:
Jade L. Ronan, Lona M. Alkhalaf, James H. Naismith, Gregory L. Challis, Stephen A. McMahon, Nadia Kadi
Publikováno v:
Philosophical Transactions of the Royal Society B, Biological Sciences. 373(1748)
Hydroxamate groups play key roles in the biological function of diverse natural products. Important examples include trichostatin A, which inhibits histone deacetylases via coordination of the active site zinc(II) ion with a hydroxamate group, and th
Rieske non-heme iron-dependent oxygenases catalyse diverse reactions in natural product biosynthesis
Publikováno v:
Natural product reports. 35(7)
Covering: up to the end of 2017 The roles played by Rieske non-heme iron-dependent oxygenases in natural product biosynthesis are reviewed, with particular focus on experimentally characterised examples. Enzymes belonging to this class are known to c
Publikováno v:
Proceedings of the National Academy of Sciences. 112:2717-2722
The bacterial tryptophanyl-tRNA synthetase inhibitor indolmycin features a unique oxazolinone heterocycle whose biogenetic origins have remained obscure for over 50 years. Here we identify and characterize the indolmycin biosynthetic pathway, using s