Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Lon Wolf R. Fong"'
Autor:
Nan Li, Yifan Wang, Shinya Neri, Yuanli Zhen, Lon Wolf R. Fong, Yawei Qiao, Xu Li, Zhen Chen, Clifford Stephan, Weiye Deng, Rui Ye, Wen Jiang, Shuxing Zhang, Yonghao Yu, Mien-Chie Hung, Junjie Chen, Steven H. Lin
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The LKB1/AMPK is crucial for maintaining cellular homeostasis and is often deregulated in tumours. Here, the authors show that the ribosylation of LKB1 by tankyrase-RNF146 axis results in attenuation of LKB1 pathway activation.
Externí odkaz:
https://doaj.org/article/9b4222506e07478e9b0dbb2ab2af74f5
Publikováno v:
Cancer metastasis reviews, vol 36, iss 4
Fong, LWR; Yang, DC; & Chen, CH. (2017). Myristoylated alanine-rich C kinase substrate (MARCKS): a multirole signaling protein in cancers. Cancer and Metastasis Reviews, 36(4), 737-747. doi: 10.1007/s10555-017-9709-6. UC Office of the President: Research Grants Program Office (RGPO). Retrieved from: http://www.escholarship.org/uc/item/4pc2b1wj
Fong, LWR; Yang, DC; & Chen, CH. (2017). Myristoylated alanine-rich C kinase substrate (MARCKS): a multirole signaling protein in cancers. Cancer and Metastasis Reviews, 36(4), 737-747. doi: 10.1007/s10555-017-9709-6. UC Office of the President: Research Grants Program Office (RGPO). Retrieved from: http://www.escholarship.org/uc/item/4pc2b1wj
© 2017, Springer Science+Business Media, LLC. Emerging evidence implicates myristoylated alanine-rich C-kinase substrate (MARCKS), a major substrate of protein kinase C (PKC), in a critical role for cancer development and progression. MARCKS is teth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deb39eb864e8e13b1181860872e66d56
https://doi.org/10.1007/s10555-017-9709-6
https://doi.org/10.1007/s10555-017-9709-6
Publikováno v:
Oncogene. 36:3588-3598
Targeted therapeutics, such as those abrogating hypoxia inducible factor (HIF)/vascular endothelial growth factor signaling, are initially effective against kidney cancer (or renal cell carcinoma, RCC); however, drug resistance frequently occurs via
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50f3ca8c09ce9a42847eb67a5dae044d
https://doi.org/10.1038/onc.2016.510
https://doi.org/10.1038/onc.2016.510
Autor:
Junjie Chen, Shuxing Zhang, Shinya Neri, Wen Jiang, Weiye Deng, Zhen Chen, Clifford Stephan, Yifan Wang, Yuanli Zhen, Mien Chie Hung, Xu Li, Lon Wolf R. Fong, Nan Li, Yawei Qiao, Rui Ye, Yonghao Yu, Steven H. Lin
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications
The LKB1/AMPK pathway plays a major role in cellular homeostasis and tumor suppression. Down-regulation of LKB1/AMPK occurs in several human cancers and has been implicated in metabolic diseases. However, the precise upstream regulation of LKB1-AMPK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2422919b5a689699982f3a5aa3a3f697
https://doi.org/10.1038/s41467-019-12377-1
https://doi.org/10.1038/s41467-019-12377-1
Publikováno v:
Signal Transduction and Targeted Therapy
Signal transduction and targeted therapy, vol 4, iss 1
Signal Transduction and Targeted Therapy, Vol 4, Iss 1, Pp 1-11 (2019)
Xu, Jihao; Chang, Wen-Hsin; Fong, Lon Wolf R; Weiss, Robert H; Yu, Sung-Liang; & Chen, Ching-Hsien. (2019). Targeting the insulin-like growth factor-1 receptor in MTAP-deficient renal cell carcinoma.. Signal transduction and targeted therapy, 4(1), 2. doi: 10.1038/s41392-019-0035-z. UC Office of the President: Research Grants Program Office (RGPO). Retrieved from: http://www.escholarship.org/uc/item/4fx902w2
Signal transduction and targeted therapy, vol 4, iss 1
Signal Transduction and Targeted Therapy, Vol 4, Iss 1, Pp 1-11 (2019)
Xu, Jihao; Chang, Wen-Hsin; Fong, Lon Wolf R; Weiss, Robert H; Yu, Sung-Liang; & Chen, Ching-Hsien. (2019). Targeting the insulin-like growth factor-1 receptor in MTAP-deficient renal cell carcinoma.. Signal transduction and targeted therapy, 4(1), 2. doi: 10.1038/s41392-019-0035-z. UC Office of the President: Research Grants Program Office (RGPO). Retrieved from: http://www.escholarship.org/uc/item/4fx902w2
Renal cell carcinoma (RCC) has emerged as a metabolic disease characterized by dysregulated expression of metabolic enzymes. Patients with metastatic RCC have an unusually poor prognosis and near-universal resistance to all current therapies. To impr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6da34fcb6b11634410274417f7662281
http://europepmc.org/articles/PMC6345872
http://europepmc.org/articles/PMC6345872
Autor:
Jing Zhai, Reen Wu, Lon Wolf R. Fong, Ching-Hsien Chen, Chun Ting Cheng, Yuan Yuan, Muhammad Arif, David K. Ann
Publikováno v:
Oncotarget
Accumulating evidence has suggested that myristoylated alanine-rich C-kinase substrate (MARCKS) is critical for regulating multiple pathophysiological processes. However, the molecular mechanism underlying increased phosphorylation of MARCKS at Ser15
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f152009a5898a419c62b51809948d8a6
https://pubmed.ncbi.nlm.nih.gov/26015406
https://pubmed.ncbi.nlm.nih.gov/26015406