Concepts for brain aging: resistance, resilience, reserve, and compensation

Autor: Thomas J. Montine, Brenna A. Cholerton, Maria M. Corrada, Steven D. Edland, Margaret E. Flanagan, Laura S. Hemmy, Claudia H. Kawas, Lon R. White

Publikováno v: Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-3 (2019)

Abstract A primary goal of research in cognitive impairment and dementia is to understand how some individuals retain sufficient cognitive function for a fulfilling life while many others are robbed of their independence, sometimes their essence, in

Externí odkaz: https://doaj.org/article/cddd98395bdc41b9b544711f0373a5ba

Mid- and later-life risk factors for predicting neuropathological brain changes associated with Alzheimer's and vascular dementia: The Honolulu Asia Aging Study and the Age, Gene/Environment Susceptibility-Reykjavik Study

Autor: Blossom C. M. Stephan, Denise M. Gaughan, Steven Edland, Villi Gudnason, Lenore J Launer, Lon R White

Publikováno v: Alzheimer'sdementia : the journal of the Alzheimer's AssociationREFERENCES.

Dementia prediction models are necessary to inform the development of dementia risk reduction strategies. Here, we examine the utility of neuropathological-based risk scores to predict clinical dementia.Models were developed for predicting Alzheimer'

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::171e9803299d383e20381067116b0df3
https://pubmed.ncbi.nlm.nih.gov/36193864

Antihypertensive medications and risk for incident dementia and Alzheimer's disease: a meta-analysis of individual participant data from prospective cohort studies

Autor: Vilmundur Guðnason, Phillip J. Tully, Caroline L. Phillips, Rebecca F. Gottesman, Osorio Meirelles, Alexa S. Beiser, B. Gwen Windham, Jayandra J. Himali, Sudha Seshadri, Stéphanie Debette, Thomas H. Mosley, Lenore J. Launer, Kendra Davis-Plourde, Lon R. White, Michael Griswold, Sanaz Sedaghat, M. Arfan Ikram, Jie Ding, Wanmei Wang, Christophe Tzourio, Matthew P. Pase

Publikováno v: The Lancet Neurology
The Lancet Neurology, Elsevier, In press, 19 (1), pp.61-70. ⟨10.1016/s1474-4422(19)30393-x⟩
Lancet Neurology, 19(1), 61-70. Lancet Publishing Group

BackgroundDementia is a major health concern for which prevention and treatment strategies remain elusive. Lowering high blood pressure with specific antihypertensive medications (AHMs) could reduce the burden of disease. We investigated whether spec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06a211189889e1699b2bfa93505f7388
https://doi.org/10.1016/s1474-4422(19)30393-x

Excessive daytime sleepiness and topographic expansion of Lewy pathology

Autor: Chol Shin, G. Webster Ross, Robert D. Abbott, Lon R. White, Jane Uyehara-Lock, Helen Petrovitch, K Masaki, Lenore J. Launer, John Duda, Caroline M. Tanner

Publikováno v: Neurology, vol 93, iss 15
Neurology

ObjectiveWhile excessive daytime sleepiness (EDS) can predate the clinical diagnosis of Parkinson disease (PD), associations with underlying PD pathogenesis are unknown. Our objective is to determine if EDS is related to brain Lewy pathology (LP), a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44107283d473dea587bd3e3d7e93e2cf
https://doi.org/10.1212/wnl.0000000000008241

Association of brain heptachlor epoxide and other organochlorine compounds with lewy pathology

Autor: Helen Petrovitch, Caroline M. Tanner, Jane Uyehara-Lock, Lon R. White, Kamal Masaki, Chris Zarow, Lenore J. Launer, John E. Duda, G. Webster Ross, William B. Studabaker, Robert D. Abbott

Publikováno v: Movement Disorders. 34:228-235

BACKGROUND Organochlorine pesticides are associated with an increased risk of Parkinson's disease. A preliminary analysis from the Honolulu-Asia Aging Study suggested that heptachlor epoxide, a metabolite from an organochlorine pesticide extensively

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e450184da422eb42abe79dd57327e0a
https://doi.org/10.1002/mds.27594