Zobrazeno 1 - 10
of 254
pro vyhledávání: '"Lon R Cardon"'
Autor:
Josine L Min, Jennifer M Taylor, J Brent Richards, Tim Watts, Fredrik H Pettersson, John Broxholme, Kourosh R Ahmadi, Gabriela L Surdulescu, Ernesto Lowy, Christian Gieger, Chris Newton-Cheh, Markus Perola, Nicole Soranzo, Ida Surakka, Cecilia M Lindgren, Jiannis Ragoussis, Andrew P Morris, Lon R Cardon, Tim D Spector, Krina T Zondervan
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22070 (2011)
The integrated analysis of genotypic and expression data for association with complex traits could identify novel genetic pathways involved in complex traits. We profiled 19,573 expression probes in Epstein-Barr virus-transformed lymphoblastoid cell
Externí odkaz:
https://doaj.org/article/982c18574fb2437d82a27dcf7bdb2ea8
Publikováno v:
PLoS Genetics, Vol 2, Iss 9, p e157 (2006)
Studies in model organisms suggest that epistasis may play an important role in the etiology of complex diseases and traits in humans. With the era of large-scale genome-wide association studies fast approaching, it is important to quantify whether i
Externí odkaz:
https://doaj.org/article/bd04836c2fe4437fbde0d150a1229c17
Autor:
Karol Estrada, Steven Froelich, Arthur Wuster, Christopher R. Bauer, Teague Sterling, Wyatt T. Clark, Yuanbin Ru, Marena Trinidad, Hong Phuc Nguyen, Amanda R. Luu, Daniel J. Wendt, Gouri Yogalingam, Guoying Karen Yu, Jonathan H. LeBowitz, Lon R. Cardon
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Prioritising genes as potential drug targets is challenging and often unsuccessful once testing efficacy in humans. Here, the authors propose an approach to identifying drug targets that uses evidence from gain- or loss-of-function mutations associat
Externí odkaz:
https://doaj.org/article/bc9abc10fee1429d8bd83e6241883e5f
Autor:
Alan R. Shuldiner, Mark J. Ratain, Braxton D. Mitchell, Nancy J. Cox, Jeffrey R. O'Connell, Lini N. Pandite, Lon R. Cardon, Yuan Liu, Nan Bing, Paul A. Wilson, Matthew R. Levine, Vasiliki Thomeas, Eric R. Gamazon, Dara Torgerson, Soma Das, Theodore G. Karrison, Kathleen A. Ryan, Emily Kistner-Griffin, Yu-Ching Cheng, Chun-Fang Xu, Michael L. Maitland
Purpose: VEGF receptor (VEGFR) kinases are important drug targets in oncology that affect function of systemic endothelial cells. To discover genetic markers that affect VEGFR inhibitor pharmacodynamics, we performed a genome-wide association study o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::539f3047746b9f3731af551934f65fcc
https://doi.org/10.1158/1078-0432.c.6524561.v1
https://doi.org/10.1158/1078-0432.c.6524561.v1
Autor:
Steven Froelich, Gouri Yogalingam, Teague Sterling, Arthur Wuster, Daniel J. Wendt, Amanda R. Luu, Lon R. Cardon, Guoying Karen Yu, Hong Phuc Nguyen, Christopher R. Bauer, Jonathan H. LeBowitz, Marena Trinidad, Karol Estrada, Wyatt T. Clark, Yuanbin Ru
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications
Nature Communications
Prioritizing genes for translation to therapeutics for common diseases has been challenging. Here, we propose an approach to identify drug targets with high probability of success by focusing on genes with both gain of function (GoF) and loss of func
Autor:
David J. Carey, Cristen J. Willer, Anthony Marcketta, Claudia Schurmann, Leland Barnard, John Penn, Suganthi Balasubramanian, Daren Liu, Joseph B. Leader, Gonçalo R. Abecasis, Marcus B. Jones, John C. Whittaker, Ashutosh K. Pandey, Ida Surakka, David H. Ledbetter, Evan Maxwell, John D. Overton, Andrew Blumenfeld, Michael N. Cantor, Robert A. Scott, Wendy K. Chung, Alexander H. Li, Alexander Lopez, Joshua D. Backman, Matthew R. Nelson, Jeffrey Staples, Giovanni Coppola, Jonathan Marchini, Xiaodong Bai, Kavita Praveen, Alan R. Shuldiner, Claudia Gonzaga-Jauregui, Aris N. Economides, Shareef Khalid, William J Salerno, Bin Ye, Cristopher V. Van Hout, Kristian Hveem, Jeffrey G. Reid, Colm O'Dushlaine, Joshua D. Hoffman, Laura M. Yerges-Armstrong, Nilanjana Banerjee, Sean O'Keeffe, Ioanna Tachmazidou, Lon R. Cardon, Alicia Hawes, Aris Baras, Ashish Yadav, George D. Yancopoulos, Lukas Habegger
Publikováno v:
Nature
The UK Biobank is a prospective study of 502,543 individuals, combining extensive phenotypic and genotypic data with streamlined access for researchers around the world1. Here we describe the release of exome-sequence data for the first 49,960 study
Autor:
Daniel J. Wendt, Christopher R. Bauer, Hong Phuc Nguyen, Gouri Yogalingam, Karol Estrada, Teague Sterling, Amanda R. Luu, Lon R. Cardon, Jonathan H. LeBowitz, Marena Trinidad, Arthur Wuster, Guoying Karen Yu, Wyatt T. Clark, Steven Froelich, Yuanbin Ru
While GWAS of common diseases has delivered thousands of novel genetic findings, prioritizing genes for translation to therapeutics has been challenging. Here, we propose an approach to resolve that issue by identifying genes that have both gain of f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26e6f1e0195fb06a1bbbb786d3290970
https://doi.org/10.1101/2020.04.02.022624
https://doi.org/10.1101/2020.04.02.022624
Autor:
Lon R. Cardon, Hakan Sakul
Publikováno v:
Molecular Dissection of Complex Traits ISBN: 9780429117770
Molecular Dissection of Complex Traits
Molecular Dissection of Complex Traits
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::563f5da1e702da0eee0be5aeaf2bc0f0
https://doi.org/10.1201/9780429117770-19
https://doi.org/10.1201/9780429117770-19
Autor:
Luke Devey, Lon R. Cardon, Sirui Zhou, Dawn Waterworth, Cong Guo, George Davey Smith, Robert A. Scott, Claudia Langenberg, Lauren E. Mokry, J. Brent Richards, Philippe Sanseau, Nicholas J. Wareham
Publikováno v:
Mokry, L E, Zhou, S, Guo, C, Scott, R A, Devey, L, Langenberg, C, Wareham, N, Waterworth, D M, Cardon, L, Sanseau, P, Davey Smith, G & Richards, B 2019, ' Interleukin-18 as a drug repositioning opportunity for inflammatory bowel disease : A Mendelian randomization study ', Scientific Reports, vol. 9, no. 1, 9386 (2019) . https://doi.org/10.1038/s41598-019-45747-2
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-7 (2019)
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-7 (2019)
Support from human genetics increases the probability of success in drug development. However, few examples exist of successful genomically-driven drug repositioning. Given that a Mendelian form of severe enterocolitis is due to up-regulation of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f510183360e555079dd02158bc2a5c4
https://www.repository.cam.ac.uk/handle/1810/307379
https://www.repository.cam.ac.uk/handle/1810/307379
Autor:
Ida Surakka, Alexander Lopez, Lukas Habegger, Shareef Khalid, William J Salerno, Andrew Blumenfeld, Bin Ye, Jeffrey G. Reid, Ashutosh K. Pandey, Alicia Hawes, John D. Overton, Giovanni Coppola, Jonathan Marchini, Wendy K. Chung, David J. Carey, David H. Ledbetter, Kristian Hveem, Aris N. Economides, Cristopher V. Van Hout, Kavita Praveen, Cristen J. Willer, Joshua D. Backman, Anthony Marcketta, Ioanna Tachmazidou, Marcus B. Jones, O’Dushlaine Colm, John Penn, Joseph B. Leader, Leland Barnard, Daren Liu, George D. Yancopoulos, Michael N. Cantor, Suganthi Balasubramanian, Laura M. Yerges-Armstrong, Alan R. Shuldiner, Claudia Gonzaga-Jauregui, John C. Whittaker, Nilanjana Banerjee, Aris Baras, Gonçalo R. Abecasis, Claudia Schurmann, Robert A. Scott, Evan Maxwell, Matthew R. Nelson, Jeffrey Staples, Ashish Yadav, Joshua D. Hoffman, Lon R. Cardon, Alexander H. Li
SUMMARYThe UK Biobank is a prospective study of 502,543 individuals, combining extensive phenotypic and genotypic data with streamlined access for researchers around the world. Here we describe the first tranche of large-scale exome sequence data for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed87f8ff1c2cbdc9569dbaa5b001bd62
https://doi.org/10.1101/572347
https://doi.org/10.1101/572347