Výsledky vyhledávání - "Lolita Stribinskiene"

Potentiation of etoposide-induced apoptosis by staurosporine in human tumor cells is associated with events downstream of DNA-protein complex formation

Autor: Daniel M. Sullivan, Lolita Stribinskiene, Richard B. Lock, Bruce S. Thompson

Publikováno v: Cancer Chemotherapy and Pharmacology. 39:399-409

Protein kinase inhibitors have demonstrated potential for use in the therapy of human cancers, in particular leukemia. Staurosporine, a protein kinase inhibitor with broad specificity, enhances the cytotoxic effects of various antitumor agents with d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e59059cbbf571e4cdfab1b3c64d5e9be
https://doi.org/10.1007/s002800050590

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Bcl-2 inhibits early apoptotic events and reveals post-mitotic multinucleation without affecting cell cycle arrest in human epithelial tumor cells exposed to etoposide

Autor: Eric Sturges, Velvizhi Ranganathan, Monica L. Farnsworth, Richard B. Lock, Lolita Stribinskiene, Mary Jane Elliott, Kathleen M. Murphy

Publikováno v: Cancer chemotherapy and pharmacology. 44(1)

Defective apoptotic mechanisms are considered to play a role in both the development of malignancy and resistance to chemotherapeutic drugs. The Bcl-2 family of proteins regulate the cellular commitment to survive or die when challenged with various

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4df3586e7b06aa20ec3d2a544e34c74
https://pubmed.ncbi.nlm.nih.gov/10367743

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Expression of Bcl-2 in human epithelial tumor (HeLa) cells enhances clonogenic survival following exposure to 5-fluoro-2'-deoxyuridine or staurosporine, but not following exposure to etoposide or doxorubicin

Autor: Lolita Stribinskiene, Richard B. Lock, Mary Jane Elliott

Publikováno v: Cancer chemotherapy and pharmacology. 41(6)

A reduced capacity for apoptosis induction is considered to play a significant role both in the development of malignancy and in tumor cell resistance to chemotherapeutic drugs. The Bcl-2 oncoprotein inhibits apoptosis induced by antitumor agents at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9917231b843d20c37df35b7bd3fb4a63
https://pubmed.ncbi.nlm.nih.gov/9554589

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Differential ability of 2,4-dinitrophenol to modulate etoposide cytotoxicity in mammalian tumor cell lines associated with inhibition of macromolecular synthesis

Autor: Richard B. Lock, Bruce S. Thompson, Lolita Stribinskiene

Publikováno v: International Journal of Oncology.

The inhibitor of oxidative phosphorylation, 2,4-dinitrophenol (DNP), abrogates etoposide cytotoxicity in murine leukemia L1210 cells without affecting the quantity of drug-induced DNA lesions. Cell cycle arrest and events associated with cell death w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcb0e3ce373dde6aaa3d4ec5d3656de3
https://doi.org/10.3892/ijo.8.2.305

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