Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Loleta M Chung"'
Autor:
Roger A. Sheldon, Lisa M. Newman, Emily Mundorff, Richard J. Fox, John C Whitman, Gjalt W. Huisman, Loleta M Chung, Steven K. Ma, S. Christopher Davis, Charlene Ching, John M. Gruber, Vesna Gavrilovic, John H. Grate, Sheela Muley, Sarena Tam
Publikováno v:
Nature Biotechnology. 25:338-344
We describe a directed evolution approach that should find broad application in generating enzymes that meet predefined process-design criteria. It augments recombination-based directed evolution by incorporating a strategy for statistical analysis o
Autor:
Yaoquan Liu, Leonard Katz, Christopher D. Reeves, W. Peter Revill, Loleta M. Chung, Qun Xue, John R. Carney
Publikováno v:
Journal of Biological Chemistry. 277:9155-9159
Ascomycin (FK520) is a structurally complex macrolide with immunosuppressant activity produced by Streptomyces hygroscopicus. The biosynthetic origin of C12-C15 and the two methoxy groups at C13 and C15 has been unclear. It was previously shown that