Výsledky vyhledávání

Special Properties of Modification of SsDNA Target by Alkylating Derivatives of Oligonucleotides in Tandem Complexes

Autor: Dmitrii V. Pyshnyi, E. M. Ivanova, Lokhov Sg, Valentina F. Zarytova

Publikováno v: Nucleosides and Nucleotides. 17:2149-2152

The influence of an effector (di-N-(2-hydroxyethyl)-phenazinium derivative of oligonucleotide) on modification of the DNA target by alkylating derivatives of oligonucleotides having various hybridization properties was studied. Being adjacent to the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::59db9ac66bc226c5d8c69cf2803ad3c1
https://doi.org/10.1080/07328319808004758

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Mini-antisense Oligonucleotides

Autor: Valentina F. Zarytova, Lokhov Sg, Inna A. Pyshnaya, E. M. Ivanova, Dmitrii V. Pyshnyi

Publikováno v: Nucleosides and Nucleotides. 16:1565-1569

A new strategy of selective DNA target modification was proposed. The using of reactive derivatives of short oligonucleotides in the presence of flanking effector pair allows one to modify DNA target only when the perfect complementary complex of DNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bfb33f07e1d402318cc812e8a689d7fc
https://doi.org/10.1080/07328319708006231

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Oligonucleotide-Peptide Conjjugates for RNA Cleavage

Autor: Dmitrii V. Pyshnyi, Lokhov Sg, Valentina F. Zarytova, Marina N. Repkova, Eugenia M. Ivanova, Alya G. Venyaminova

Publikováno v: Nucleosides and Nucleotides. 16:1571-1574

Directed cleavage of RNA phosphodiester bonds by peptidyloligodeoxyribonucleotide containing the peptide residues with the alternated hydrophobic and basic amino acids was demonstrated.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c4688b6a59afaf3ef6e7dd8154b0746b
https://doi.org/10.1080/07328319708006232

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A new approach to enhancing the efficiency and specificity of interaction in duplexes by the use of tandem structure

Autor: E. M. Ivanova, Dmitrii V. Pyshnyi, Inna A. Pyshnaya, Valentina F. Zarytova, Lokhov Sg, M. A. Podyminogin

Publikováno v: Pure and Applied Chemistry. 68:1321-1328

Examined in this work is ssDNA recognition by tetranucleotides and their alkylating derivatives in the presence of effectors (native oligonucleotides and their derivatives bearing a duplex stabilizing group such as phenazinium). Though tetranucleotid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::140b4c335edab8d0e837bc1613e6f086
https://doi.org/10.1351/pac199668061321

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A New Approach to Potentiate Site-Specific Hybridization: A set of Hydrophobic Heterobifunctional Short Oligodeoxyribonucleotides

Autor: Valentina F. Zarytova, Lokhov Sg, E. M. Ivanova, D. Sergeev, P. E. Vorobjev, Dmitrii V. Pyshnyi, Inna A. Pyshnaya

Publikováno v: Nucleosides, Nucleotides and Nucleic Acids. 14:1065-1068

An effective approach to enhance the short oligonucleotide reagent to attack ssDNA based on the use of a set of short oligonucleotide heterobifunctional derivatives bearing steroid residues is proposed.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1fb768fe28eb9fd364316abe6babb74c
https://doi.org/10.1080/15257779508012535

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Ethidium and azidoethidium oligonucleotide derivatives: Synthesis, complementary complex formation and sequence-specific photomodification of the single-stranded and double-stranded target oligo- and polynucleotides

Autor: Kropachev K, Lokhov Sg, Lebedev Av, N. V. Bulychev, Koshkin Aa, Mamaev Sv, Valentin V. Vlassov

Publikováno v: Journal of Molecular Recognition. 7:177-188

Oligodeoxyribonucleotide derivatives containing ethidium or azidoethidium residues attached to 3' and/or 5' end were prepared. These derivatives formed tight specific complexes with complementary oligodeoxyribonucleotides where each attached ethidium

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71484bb41df5853ef84b7df5ba09fea7
https://doi.org/10.1002/jmr.300070305

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A new strategy of discrimination of a point mutation by tandem of short oligonucleotides

Autor: E. M. Ivanova, Dmitrii V. Pyshnyi, Lokhov Sg, M. A. Podyminogin, Valentina F. Zarytova

Publikováno v: Nucleosides, nucleotidesnucleic acids. 19(10-12)

A new strategy based on the use of cooperative tandems of short oligonu-cleotide derivatives (TSOD) has been proposed to discriminate a “right” DNA target from a target containing a single nucleotide discrepancy. Modification of a DNA target by o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::834c8fd391521494a019c4696573d9f0
https://pubmed.ncbi.nlm.nih.gov/11200282

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