Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Lokesh Nigam"'
Autor:
Kamaldeep Gill, Lokesh Nigam, Ratnakar Singh, Suresh Kumar, Naidu Subbarao, Shyam Singh Chauhan, Sharmistha Dey
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e101525 (2014)
p38α is a significant target for drug designing against cancer. The overproduction of p38α MAPK promotes tumorigenesis in head and neck squamous cell carcinoma (HNSCC). The ATP binding and an allosteric site referred as DFG are the key sites of the
Externí odkaz:
https://doaj.org/article/e69626b9d74f421a81d1c006fa4164d8
Publikováno v:
Protein & Peptide Letters. 28:1281-1289
Background: Human serum albumin (HSA) is one of the most abundant proteins in the blood plasma, urine as well as in the organic matrix of renal calculi. Macromolecules present in the urine modulate kidney stone formation either by stimulating or inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::080c66f8f0ba1b89bd1d6097b361bcac
https://doi.org/10.2174/0929866528666210930165426
https://doi.org/10.2174/0929866528666210930165426
Autor:
Yinghui Zhu, Miso Park, Mariam Murtadha, Enrico Caserta, Le Xuan Truong Nguyen, Mahmoud Singer, Marc Denisse Estepa, Lokesh Nigam, Ada Alice Dona', James F Sanchez, Theophilus Tandoh, Man Li, Bin Zhang, Ya-Huei Kuo, Guido Marcucci, John C Williams, Flavia Pichiorri
Publikováno v:
Blood. 140:89-90
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0928756cba2a6e372ff1082f06e55ffb
https://doi.org/10.1182/blood-2022-170300
https://doi.org/10.1182/blood-2022-170300
Autor:
Ada Alice Dona, Enrico Caserta, Mahmoud Singer, Theophilus Tandoh, Lokesh Nigam, Janet Winchester, Arnab Chowdhury, Yinghui Zhu, Mariam Murtadha, Alex Pozhitkov, James F Sanchez, Hawa Vahed, Matt Coffey, Guido Marcucci, Amrita Krishnan, Gerard Nuovo, Douglas W. Sborov, Craig C Hofmeister, Flavia Pichiorri
Reovirus is an oncolytic virus with natural tropism for cancer cells. We previously showed that reovirus intravenous administration in myeloma patients was safe, but disease control associated with viral replication in the cancer cells was not observ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5576ab991f727a7fb171e0e59fd1a296
https://doi.org/10.1101/2022.03.29.22272857
https://doi.org/10.1101/2022.03.29.22272857
Autor:
Amrendra Pratap Singh, Naidu Subbarao, Yudhishthir Yadav, Shashank Shekhar, Lokesh Nigam, Sharmistha Dey
Publikováno v:
Molecular Diversity. 25:2261-2270
Inhibition of Sirtuin2 (SIRT2) protein rescues the α-synuclein toxicity in vitro and in vivo models of Parkinson’s disease (PD). Thioacetyl group can structurally mimic the acetyl group and restrain the deacetylating p53 reaction by SIRT2. This wo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09753f0f7029df2b1727864782e728e0
https://doi.org/10.1007/s11030-020-10116-z
https://doi.org/10.1007/s11030-020-10116-z
Publikováno v:
Handbook of Oxidative Stress in Cancer: Mechanistic Aspects ISBN: 9789811545016
Handbook of Oxidative Stress in Cancer: Mechanistic Aspects
Handbook of Oxidative Stress in Cancer: Mechanistic Aspects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::801a15de02e1e262d0504ef42ff4cff5
https://doi.org/10.1007/978-981-15-9411-3_92
https://doi.org/10.1007/978-981-15-9411-3_92
Autor:
Sumiran Kumar Gurung, Naidu Subbarao, Archana Bist, Debasish Mohapatra, Amir Azam, Guru Prasad Sharma, Lokesh Nigam, Afreen Inam, Neelima Mondal, Shantibhusan Senapati
Publikováno v:
Toxicology in Vitro. 60:420-436
Metastatic prostate cancer, with no effective treatment, is among the leading causes of cancer-associated deaths in men. Overexpression of p38αMAPK has been observed in neuroendocrine prostate cancer patients and in both DU145 and PC-3 cell lines an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46d77a5c4ff7c065d82e7f0bae1a4ff5
https://doi.org/10.1016/j.tiv.2019.06.003
https://doi.org/10.1016/j.tiv.2019.06.003
Autor:
Ada Dona, Flavia Pichiorri, Amrita Krishnan, Lokesh Nigam, Yinghui Zhu, Guido Marcucci, Le Xuan Truong Nguyen, Estelle Troadec, James F. Sanchez, Enrico Caserta
Publikováno v:
Blood. 138:2661-2661
INTRODUCTION: Although the treatment of patients with multiple myeloma (MM) has dramatically improved, those with high-risk characteristics, including the deletion or mutation of the master tumor suppressor gene TP53 on chromosome 17, experience limi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c78ac1bb70ae5b83646eacdaa45c9c9d
https://doi.org/10.1182/blood-2021-151506
https://doi.org/10.1182/blood-2021-151506
Autor:
Rajesh Kumar, Amrendra Pratap Singh, Naidu Subbarao, Lokesh Nigam, Kusum Singh, Sharmistha Dey
Publikováno v:
European Journal of Medicinal Chemistry. 127:909-916
Sirtuin 1 (SIRT1) is one of the member of the mammalian proteins of the Sirtuin family of NAD+ dependent deacetylases, has recently been shown to attenuate amyloidogenic processing of amyloid protein precursor (APP) in in-vitro cell culture studies a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a06509beff7be33d2baea56cc76d602c
https://doi.org/10.1016/j.ejmech.2016.11.001
https://doi.org/10.1016/j.ejmech.2016.11.001
Autor:
Quoc Trung Ly, Bin Zhang, Tram Kim Thi Pham, Lokesh Nigam, Trung Quoc Lam, Le Xuan Truong Nguyen, Yasmin Elhajmoussa, Guido Marcucci, Dai Dong Thi Nguyen, Vinod Pullarkat, Vo Thanh Thao Nguyen, Trinh To Tat, Ya-Huei Kuo, Lianjun Zhang, Flavia Pichiorri, Dinh Hoa Hoang, Michael S. Nelson, Dang Quan Nguyen, Huu Duc Ho
Publikováno v:
Journal of cellular physiologyREFERENCES. 235(10)
Transcription initiation factor 90 (TIF-90), an alternatively spliced variant of TIF-IA, differs by a 90 base pair deletion of exon 6. TIF-90 has been shown to regulate ribosomal RNA (rRNA) synthesis by interacting with polymerase I (Pol I) during th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::830e9ece37c606b9aab9162e41db318a
https://pubmed.ncbi.nlm.nih.gov/32159236
https://pubmed.ncbi.nlm.nih.gov/32159236