Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Lokanand Koduru"'
Autor:
Evaldas Klumbys, Wei Xu, Lokanand Koduru, Elena Heng, Yifeng Wei, Fong Tian Wong, Huimin Zhao, Ee Lui Ang
Publikováno v:
Microbial Cell Factories, Vol 23, Iss 1, Pp 1-12 (2024)
Abstract Background Streptomyces is renowned for its robust biosynthetic capacity in producing medically relevant natural products. However, the majority of natural products biosynthetic gene clusters (BGCs) either yield low amounts of natural produc
Externí odkaz:
https://doaj.org/article/c15208acd87340bbb1be85956098c0c5
Autor:
Miselle Tiana Hengardi, Cui Liang, Keshiniy Madivannan, Lay Kien Yang, Lokanand Koduru, Yoganathan Kanagasundaram, Prakash Arumugam
Publikováno v:
Microbial Cell Factories, Vol 23, Iss 1, Pp 1-16 (2024)
Abstract Background Mycosporine-like amino acids (MAAs) are a class of strongly UV-absorbing compounds produced by cyanobacteria, algae and corals and are promising candidates for natural sunscreen components. Low MAA yields from natural sources, cou
Externí odkaz:
https://doaj.org/article/91f2133ff30b4959af30d5e618f0e9d8
Exploring a general multi-pronged activation strategy for natural product discovery in Actinomycetes
Autor:
Dillon W. P. Tay, Lee Ling Tan, Elena Heng, Nadiah Zulkarnain, Kuan Chieh Ching, Mario Wibowo, Elaine Jinfeng Chin, Zann Yi Qi Tan, Chung Yan Leong, Veronica Wee Pin Ng, Lay Kien Yang, Deborah C. S. Seow, Yi Wee Lim, Winston Koh, Lokanand Koduru, Yoganathan Kanagasundaram, Siew Bee Ng, Yee Hwee Lim, Fong Tian Wong
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract Natural products possess significant therapeutic potential but remain underutilized despite advances in genomics and bioinformatics. While there are approaches to activate and upregulate natural product biosynthesis in both native and hetero
Externí odkaz:
https://doaj.org/article/660d265250cd43acbdc9f0d5d7470752
Autor:
Elena Heng, Lee Ling Tan, Dillon W.P. Tay, Yee Hwee Lim, Lay-Kien Yang, Deborah C.S. Seow, Chung Yan Leong, Veronica Ng, Siew Bee Ng, Yoganathan Kanagasundaram, Fong Tian Wong, Lokanand Koduru
Publikováno v:
Synthetic and Systems Biotechnology, Vol 8, Iss 2, Pp 253-261 (2023)
With the advent of rapid automated in silico identification of biosynthetic gene clusters (BGCs), genomics presents vast opportunities to accelerate natural product (NP) discovery. However, prolific NP producers, Streptomyces, are exceptionally GC-ri
Externí odkaz:
https://doaj.org/article/b6c65dd9a4984e7c9a75ea8fc00af782
Autor:
Lee Ling Tan, Elena Heng, Chung Yan Leong, Veronica Ng, Lay Kien Yang, Deborah Chwee San Seow, Lokanand Koduru, Yoganathan Kanagasundaram, Siew Bee Ng, Guangrong Peh, Yee Hwee Lim, Fong Tian Wong
Publikováno v:
Biomolecules, Vol 14, Iss 4, p 486 (2024)
In recent years, CRISPR-Cas toolboxes for Streptomyces editing have rapidly accelerated natural product discovery and engineering. However, Cas efficiencies are oftentimes strain-dependent, and the commonly used Streptococcus pyogenes Cas9 (SpCas9) i
Externí odkaz:
https://doaj.org/article/d9a3d8aa598b4a18a18c5353dc208afb
Mitigating biomass composition uncertainties in flux balance analysis using ensemble representations
Autor:
Yoon-Mi Choi, Dong-Hyuk Choi, Yi Qing Lee, Lokanand Koduru, Nathan E. Lewis, Meiyappan Lakshmanan, Dong-Yup Lee
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 3736-3745 (2023)
The biomass equation is a critical component in genome-scale metabolic models (GEMs): it is used as the de facto objective function in flux balance analysis (FBA). This equation accounts for the quantities of all known biomass precursors that are req
Externí odkaz:
https://doaj.org/article/0a884a6507744c7babcf42477f68670a
Autor:
Lokanand Koduru, Meiyappan Lakshmanan, Shawn Hoon, Dong-Yup Lee, Yuan Kun Lee, Dave Siak-Wei Ow
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
The incidence and prevalence of inflammatory disorders have increased globally, and is projected to double in the next decade. Gut microbiome-based therapeutics have shown promise in ameliorating chronic inflammation. However, they are largely experi
Externí odkaz:
https://doaj.org/article/b8c41423612f4c6c9344cde186afbac3
Publikováno v:
Microbial Cell Factories, Vol 17, Iss 1, Pp 1-12 (2018)
Abstract Background Cellular metabolism is tightly regulated by hard-wired multiple layers of biological processes to achieve robust and homeostatic states given the limited resources. As a result, even the most intuitive enzyme-centric metabolic eng
Externí odkaz:
https://doaj.org/article/238318946ea24da7bd64cb630c054822
Autor:
Elaine Tiong, Ying Sin Koo, Jiawu Bi, Lokanand Koduru, Winston Koh, Yee Hwee Lim, Fong Tian Wong
Low recycling rates have resulted in the alarming rate of accumulation of a widely used plastic material, polyethylene terephthalate (PET). With the build-up of plastics in our environment, there is an urgent need to source for more sustainable solut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0555e9c4e295c28bdf9943d76629dfb
https://doi.org/10.1101/2023.04.17.537204
https://doi.org/10.1101/2023.04.17.537204
Autor:
Elena Heng, Lee Ling Tan, Dillon W. P. Tay, Yee Hwee Lim, Lay-Kien Yang, Deborah C.S. Seow, Chung Yan Leong, Veronica Ng, Siew Bee Ng, Yoganathan Kanagasundaram, Fong Tian Wong, Lokanand Koduru
With the advent of rapid automatedin silicoidentification of biosynthetic gene clusters (BGCs), genomics presents vast opportunities to accelerate natural product (NP) discovery. However, prolific NP producers,Streptomyces, are exceptionally GC-rich
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62d53e82e79e276898728c6ea9f03c2b
https://doi.org/10.1101/2022.12.05.519232
https://doi.org/10.1101/2022.12.05.519232