Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Lok Yan Yim"'
Autor:
Xiaoen He, Yik Chun Wong, Menglong Zhong, Yufei Mo, Bo Li, Lok Yan Yim, Xin Li, Wan Liu, Yanhua Du, Hui Wang, Haoji Zhang, Zhiwei Chen
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 6 (2023)
ABSTRACT An effective vaccine for combination antiretroviral therapy (cART)-free virologic control of HIV-1 by enhancing antigen-specific effector-memory CD8+ T lymphocytes could be useful in controlling the AIDS pandemic. Previously, we demonstrated
Externí odkaz:
https://doaj.org/article/7809558ce08e421e9b5fed830a5e72ec
Autor:
Yufei Mo, Ming Yue, Lok Yan Yim, Runhong Zhou, Chunhao Yu, Qiaoli Peng, Ying Zhou, Tsz-Yat Luk, Grace Chung-Yan Lui, Huarong Huang, Chun Yu Hubert Lim, Hui Wang, Li Liu, Hongzhe Sun, Jun Wang, Youqiang Song, Zhiwei Chen
Publikováno v:
EBioMedicine, Vol 98, Iss , Pp 104877- (2023)
Summary: Background: HIV-1-associated immune activation drives CD4+ T cell depletion and the development of acquired immunodeficiency syndrome. We aimed to determine the role of nicotinamide mononucleotide (NMN), the direct precursor of nicotinamide
Externí odkaz:
https://doaj.org/article/54e9a91cd4604b2a9a8e451b41efab99
Autor:
Mengyue Niu, Yik Chun Wong, Hui Wang, Xin Li, Chun Yin Chan, Qi Zhang, Lijun Ling, Lin Cheng, Ruoke Wang, Yanhua Du, Lok Yan Yim, Xia Jin, Haoji Zhang, Linqi Zhang, Zhiwei Chen
Publikováno v:
Cell Reports, Vol 36, Iss 8, Pp 109611- (2021)
Summary: Although progress has been made on constructing potent bi-specific broadly neutralizing antibody (bi-bNAb), few bi-bNAbs have been evaluated against HIV-1/AIDS in non-human primates (NHPs). Here, we report the efficacy of a tandem bi-bNAb, n
Externí odkaz:
https://doaj.org/article/502dbbbebcab4dd28d1f50fc80426f9a
Autor:
Yik Chun Wong, Wan Liu, Lok Yan Yim, Xin Li, Hui Wang, Ming Yue, Mengyue Niu, Lin Cheng, Lijun Ling, Yanhua Du, Samantha M Y Chen, Ka-Wai Cheung, Haibo Wang, Xian Tang, Jiansong Tang, Haoji Zhang, Youqiang Song, Lisa A Chakrabarti, Zhiwei Chen
Publikováno v:
PLoS Pathogens, Vol 17, Iss 6, p e1009647 (2021)
HIV-1 functional cure requires sustained viral suppression without antiretroviral therapy. While effector-memory CD8+ T lymphocytes are essential for viremia control, few vaccines elicit such cellular immunity that could be potently recalled upon vir
Externí odkaz:
https://doaj.org/article/e61ea9ee96c84779a615ee17725cd595
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 18, p 4639 (2019)
Systemic lupus erythematosus (SLE) is a chronic, multifactorial autoimmune disease that predominantly affects young females. Dysregulation of different immune cell populations leads to self-tolerance breakdown and subsequent multiple organ damage as
Externí odkaz:
https://doaj.org/article/8f0f9614aec14e25aa4ea0a4c1d964b0
Autor:
Sheng Yan, Lok Yan Yim, Rachel Chun Yee Tam, Albert Chan, Liwei Lu, Chak Sing Lau, Vera Sau-Fong Chan
Publikováno v:
International Journal of Molecular Sciences, Vol 17, Iss 8, p 1282 (2016)
Systemic lupus erythematosus (SLE) is a chronic multi-organ autoimmune disease characterized by hyperactivated immune responses to self-antigens and persistent systemic inflammation. Previously, we reported abnormalities in circulating and bone marro
Externí odkaz:
https://doaj.org/article/71b70a7967e049358b91911f147989c6
Autor:
Lok Yan Yim, Ka Shing Lam, Tsz-Yat Luk, Yufei Mo, Xiaofan Lu, Jinlin Wang, Ka-Wai Cheung, Grace Chung Yan Lui, Denise Pui Chung Chan, Bonnie Chun Kwan Wong, Thomas Tsz-Kan Lau, Chiu Bong Ngan, Dongyan Zhou, Yik Chun Wong, Zhiwu Tan, Li Liu, Hao Wu, Tong Zhang, Shui Shan Lee, Zhiwei Chen
Publikováno v:
Journal of Virology. 97
Incomplete eradication of HIV-1 latency reservoirs remains the major hurdle in achieving a complete HIV/AIDS cure. Dissecting the facilitator of latency reservoir establishment may aid the discovery of druggable targets for HIV-1 cure.
Autor:
Samantha M. Y. Chen, Yik Chun Wong, Lok Yan Yim, Haoji Zhang, Hui Wang, Grace Chung Yan Lui, Xin Li, Xian Tang, Lin Cheng, Yanhua Du, Qiaoli Peng, Jinlin Wang, Hau-yee Kwok, Haode Huang, Thomas Tsz-Kan Lau, Denise Pui Chung Chan, Bonnie Chun Kwan Wong, Li Liu, Lisa A. Chakrabarti, Shui Shan Lee, Zhiwei Chen
Publikováno v:
Journal of Virology. 96
This study presents that ICVAX, a PD1-based DNA vaccine against HIV-1, could induce broad and polyfunctional T cell responses against different HIV-1 subtypes. ICVAX encodes a recombinant antigen consisting of the human soluble PD1 domain fused with
Autor:
Yufei Mo, Kelvin Kai-Wang To, Runhong Zhou, Li Liu, Tianyu Cao, Haode Huang, Zhenglong Du, Chun Yu Hubert Lim, Lok-Yan Yim, Tsz-Yat Luk, Jacky Man-Chun Chan, Thomas Shiu-Hong Chik, Daphne Pui-Ling Lau, Owen Tak-Yin Tsang, Anthony Raymond Tam, Ivan Fan-Ngai Hung, Kwok-Yung Yuen, Zhiwei Chen
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2022)
Frontiers in Immunology, Vol 12 (2022)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection results in rapid T lymphocytopenia and functional impairment of T cells. The underlying mechanism, however, remains incompletely understood. In this study, we focused on character
Autor:
Yanhua Du, Lok Yan Yim, Jiansong Tang, Zhiwei Chen, Xian Tang, Ming Yue, Hui Wang, Samantha M. Y. Chen, Ka-Wai Cheung, Mengyue Niu, Wan Liu, Haibo Wang, Lijun Ling, Yik Chun Wong, Xin Li, Lin Cheng, Haoji Zhang, You-Qiang Song, Lisa A. Chakrabarti
Publikováno v:
PLoS Pathogens
PLoS Pathogens, 2021, 17 (6), pp.e1009647. ⟨10.1371/journal.ppat.1009647⟩
PLoS Pathogens, Vol 17, Iss 6, p e1009647 (2021)
PLoS Pathogens, 2021, 17 (6), pp.e1009647. ⟨10.1371/journal.ppat.1009647⟩
PLoS Pathogens, Vol 17, Iss 6, p e1009647 (2021)
HIV-1 functional cure requires sustained viral suppression without antiretroviral therapy. While effector-memory CD8+ T lymphocytes are essential for viremia control, few vaccines elicit such cellular immunity that could be potently recalled upon vir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0e0871743b6f86736307c2ac4b04b66
https://hal-pasteur.archives-ouvertes.fr/pasteur-04133574
https://hal-pasteur.archives-ouvertes.fr/pasteur-04133574