Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Lok Hei Chan"'
Autor:
Wesley L Cai, Jocelyn Fang-Yi Chen, Huacui Chen, Emily Wingrove, Sarah J Kurley, Lok Hei Chan, Meiling Zhang, Anna Arnal-Estape, Minghui Zhao, Amer Balabaki, Wenxue Li, Xufen Yu, Ethan D Krop, Yali Dou, Yansheng Liu, Jian Jin, Thomas F Westbrook, Don X Nguyen, Qin Yan
Publikováno v:
eLife, Vol 11 (2022)
Metastatic breast cancer remains a major cause of cancer-related deaths in women, and there are few effective therapies against this advanced disease. Emerging evidence suggests that key steps of tumor progression and metastasis are controlled by rev
Externí odkaz:
https://doaj.org/article/58606a0ba92e4cb2b78d6211456a60e4
Autor:
Lok Hei Chan, Lei Zhou, Kai Yu Ng, Tin Lok Wong, Terence K. Lee, Rakesh Sharma, Jane H. Loong, Yick Pang Ching, Yun-Fei Yuan, Dan Xie, Chung Mau Lo, Kwan Man, Benedetta Artegiani, Hans Clevers, Helen H. Yan, Suet Yi Leung, Stéphane Richard, Xin-Yuan Guan, Michael S.Y. Huen, Stephanie Ma
Publikováno v:
Cell Reports, Vol 25, Iss 3, Pp 690-701.e8 (2018)
Summary: Arginine methylation is a post-translational modification that plays pivotal roles in signal transduction and gene transcription during cell fate determination. We found protein methyltransferase 6 (PRMT6) to be frequently downregulated in h
Externí odkaz:
https://doaj.org/article/94d362baf9af4bfd950842e35b71f463
Autor:
Stephanie Ma, Alice Carrier, Nelson J Dusetti, Terence K Lee, Dan Xie, Yunfei Yuan, Nikki P Lee, Xin-Yuan Guan, Man Tong, Stella Chai, Lok-Hei Chan, Kai-Yu Ng
Effects of TP53INP1 shRNAs on migration and invasion was rescued by TP53INP1 overexpression, ruling out potential off-target effects of the knockdown shRNAs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2971774098e2edb95159503b2486f573
https://doi.org/10.1158/0008-5472.22414349.v1
https://doi.org/10.1158/0008-5472.22414349.v1
Autor:
Stephanie Ma, Alice Carrier, Nelson J Dusetti, Terence K Lee, Dan Xie, Yunfei Yuan, Nikki P Lee, Xin-Yuan Guan, Man Tong, Stella Chai, Lok-Hei Chan, Kai-Yu Ng
Supplementary Tables 1-3 contains primer sequences for qPCR, luciferase reporter and ChIP assays. Figure Legends for Supplementary Figures 1-4 are also included.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::974f10c764775ad3b4097d242b7e5b54
https://doi.org/10.1158/0008-5472.22414340
https://doi.org/10.1158/0008-5472.22414340
Autor:
Stephanie Ma, Alice Carrier, Nelson J Dusetti, Terence K Lee, Dan Xie, Yunfei Yuan, Nikki P Lee, Xin-Yuan Guan, Man Tong, Stella Chai, Lok-Hei Chan, Kai-Yu Ng
Identifying critical factors involved in the metastatic progression of hepatocellular carcinoma (HCC) may offer important therapeutic opportunities. Here, we report that the proapoptotic stress response factor TP53INP1 is often selectively downregula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd9097f2c1784e6d221fae71ad5383bb
https://doi.org/10.1158/0008-5472.c.6508952.v1
https://doi.org/10.1158/0008-5472.c.6508952.v1
Autor:
Bryan P. Yan, William H. S. Lai, Christy K. Y. Chan, Stephen Chun‐Hin Chan, Lok‐Hei Chan, Ka‐Ming Lam, Ho‐Wang Lau, Chak‐Ming Ng, Lok‐Yin Tai, Kin‐Wai Yip, Olivia T. L. To, Ben Freedman, Yukkee C. Poh, Ming‐Zher Poh
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 8 (2018)
BackgroundWe aimed to evaluate a novel method of atrial fibrillation (AF) screening using an iPhone camera to detect and analyze photoplethysmographic signals from the face without physical contact by extracting subtle beat‐to‐beat variations of
Externí odkaz:
https://doaj.org/article/6717271b9ab3482b911eac27a3618363
Autor:
Shlomit Jessel, Wesley L. Cai, Xiaoni Liu, Kim Blenman, Carmen J. Booth, Marcus Bosenberg, Goran Micevic, Shang-Min Zhang, Yangyi Zhang, William Damsky, Harriet M. Kluger, Meaghan K. McGeary, Qin Yan, Jiesi Luo, Eric Song, Akiko Iwasaki, Durga Thakral, Mario Sznol, Mingzhu Yin, Lok Hei Chan, Lucia B. Jilaveanu
Publikováno v:
Nature. 598:682-687
Tumours use various strategies to evade immune surveillance1,2. Immunotherapies targeting tumour immune evasion such as immune checkpoint blockade have shown considerable efficacy on multiple cancers3,4 but are ineffective for most patients due to pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c935e3b9c47ac6de523df0827385669c
https://doi.org/10.1038/s41586-021-03994-2
https://doi.org/10.1038/s41586-021-03994-2
Autor:
Jocelyn Fang-Yi Chen, Wesley L Cai, Huacui Chen, Emily Wingrove, Sarah J Kurley, Lok Hei Chan, Meiling Zhang, Anna Arnal-Estape, Minghui Zhao, Amer Balabaki, Wenxue Li, Xufen Yu, Ethan D Krop, Yali Dou, Yansheng Liu, Jian Jin, Thomas F Westbrook, Don X Nguyen, Qin Yan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85b8b9be92e3185c593caa3249e8f241
https://doi.org/10.7554/elife.78163.sa2
https://doi.org/10.7554/elife.78163.sa2
Autor:
Terence K. Lee, KY Ng, Phillis W.F. Kau, Noélia Che, Man Tong, Stephanie Ma, Tin Lok Wong, Michael S.Y. Huen, Lok Hei Chan, Jing Ping Yun
Publikováno v:
Cancer Letters. 501:247-262
Autophagy is a critical survival factor for cancer cells, whereby it maintains cellular homeostasis by degrading damaged organelles and unwanted proteins and supports cellular biosynthesis in response to stress. Cancer cells, including hepatocellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28638242c4643c1c05f083533c21f63b
https://doi.org/10.1016/j.canlet.2020.11.002
https://doi.org/10.1016/j.canlet.2020.11.002
Autor:
Wesley L Cai, Jocelyn F Chen, Huacui Chen, Emily Wingrove, Sarah J Kurley, Lok Hei Chan, Meiling Zhang, Anna Arnal-Estapé, Minghui Zhao, Amer Balabaki, Wenxue Li, Xufen Yu, Yali Dou, Yansheng Liu, Jian Jin, Thomas F Westbrook, Don Nguyen, Qin Yan
Metastatic breast cancer remains a major cause of cancer related deaths in women and there are few effective therapies against this advanced disease. Emerging evidence suggests that key steps of tumor progression and metastasis are controlled by reve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::469ba91ae958a539a9dbb5fe47607b4b
https://doi.org/10.1101/2022.03.30.486357
https://doi.org/10.1101/2022.03.30.486357