Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Lok Hang Mak"'
Autor:
Agostino Cilibrizzi, Ramon Vilar, Marina Fedorova, Inna Guterman, Lok Hang Mak, Gillian F. Whyte, Rudiger Woscholski, Robin J. Leatherbarrow, Juliet Collins
Publikováno v:
Dalton transactions (Cambridge, England : 2003). 45(16)
Vanadium complexes have been previously utilised as potent inhibitors of cysteine based phosphatases (CBPs). Herein, we present the synthesis and characterisation of two new fluorescently labelled vanadyl complexes (14 and 15) with bridged di-picolin
Autor:
Ennio Capria, Andrea Fantuzzi, Gianfranco Gilardi, Lok Hang Mak, Paola Panicco, Stephen P. Collins, Vikash R. Dodhia
Publikováno v:
Analytical Chemistry. 83:3831-3839
Over the past two decades, a wealth of information on the human cytochrome P450 enzymes and their role in drug metabolism both in vitro and in vivo has been gathered. Our understanding of this area has progressed greatly, but our confidence in the de
Autor:
Ennio Capria, Andrea Fantuzzi, Lok Hang Mak, Gianfranco Gilardi, Stephen P. Collins, Vikash R. Dodhia, Graham Somers, Ejaz Huq, Sheila J. Sadeghi
Publikováno v:
Analytical Chemistry. 82:10222-10227
This paper is the first report of a P450-electrode in a microfluidic format. A 30 μL microfluidic cell was made in poly(methyl methacrylate) containing the inlet, outlet, and reaction chamber with two electrode strips, one of which contains the huma
Publikováno v:
Journal of Chemical Biology. 3:157-163
PTEN (phosphatase and tensin homologue deleted on chromosome 10) is a phosphatidylinositol triphosphate 3-phosphatase that counteracts phosphoinositide 3-kinases and has subsequently been implied as a valuable drug target for diabetes and cancer. Rec
Publikováno v:
Sensors & Transducers, Vol 113, Iss 2, Pp 140-149 (2010)
We describe a new kind of biosensor for the electro-magnetic sensing of analytes such as antibodies. In the present study the molecules bovine serum albumin (BSA) and the corresponding antibody (Anti-BSA) as well as biotin and NeutrAvidin are used as
Autor:
Rudiger Woscholski, Martin Lowe, Guanhua Yan, Zenobia B. Mehta, Peter G. Billcliff, Christopher J. Noakes, Lok Hang Mak
Publikováno v:
Billcliff, P, Noakes, C J, Mehta, Z B, Yan, G, Mak, L, Woscholski, R & Lowe, M 2016, ' OCRL1 engages with the F-BAR protein pacsin 2 to promote biogenesis of membrane-trafficking intermediates. ', Molecular Biology of the Cell, vol. 27, no. 1, pp. 90-107 . https://doi.org/10.1091/mbc.E15-06-0329
Molecular Biology of the Cell
Molecular Biology of the Cell
The Lowe syndrome protein OCRL1 binds via IPIP27A to the F-BAR protein pacsin 2 to promote the biogenesis of trafficking intermediates containing the mannose 6-phosphate receptor at the trans-Golgi network and endosomes.
Mutation of the inositol
Mutation of the inositol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::168888dd2101617a87586d40ce5b3666
https://pure.manchester.ac.uk/ws/files/25941833/POST-PEER-REVIEW-PUBLISHERS.PDF
https://pure.manchester.ac.uk/ws/files/25941833/POST-PEER-REVIEW-PUBLISHERS.PDF
Autor:
Rudiger Woscholski, Lok Hang Mak
PTEN (phosphatase and tensin homologue deleted on chromosome 10) is well known as a tumour suppressor. It's PI(3,4,5)P3 lipid phosphatase activity is an important counteracting mechanism in PI 3-kinase (phosphoinositide 3-kinase) signalling. Furtherm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8327c8125d8a3611b1c07afdd48ad1dd
http://hdl.handle.net/10044/1/21652
http://hdl.handle.net/10044/1/21652
Publikováno v:
Sensors and Actuators B: Chemical. 114:132-140
We report on the development of a high-sensitivity biosensor combining an electrical detection of microbead labelled analytes with a magnetic system for binding strength measurements. The new sensor technology allows the determination of specific bin
Autor:
Piers R. J. Gaffney, Rudiger Woscholski, Oscar Ces, Richard H. Templer, Edward W. Tate, Samuel Furse, Lok Hang Mak
Publikováno v:
Organicbiomolecular chemistry. 13(7)
In this paper evidence is presented that the fatty acid component of an inositide substrate affects the kinetic parameters of the lipid phosphatase Salmonella Outer Protein B (SopB). A succinct route was used to prepare the naturally occurring enanti
Autor:
Kerry, O'Donnelly, Guangyuan, Zhao, Priya, Patel, M Salman, Butt, Lok Hang, Mak, Simon, Kretschmer, Rudiger, Woscholski, Laura M C, Barter
Publikováno v:
Plant Methods
Background Rubisco (Ribulose-1,5-bisphosphate carboxylase/oxygenase) is a Calvin Cycle enzyme involved in CO2 assimilation. It is thought to be a major cause of photosynthetic inefficiency, suffering from both a slow catalytic rate and lack of specif