Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Lois S, Weisman"'
Autor:
Ron Benyair, Sai Srinivas Panapakkam Giridharan, Pilar Rivero-Ríos, Junya Hasegawa, Emily Bristow, Eeva-Liisa Eskelinen, Merav D Shmueli, Vered Fishbain-Yoskovitz, Yifat Merbl, Lisa M Sharkey, Henry L. Paulson, Phyllis I Hanson, Samarjit Patnaik, Ismael Al-Ramahi, Juan Botas, Juan Marugan, Lois S. Weisman
Publikováno v:
Autophagy Reports, Vol 2, Iss 1 (2023)
Many neurodegenerative diseases, including Huntington’s disease (HD) and Alzheimer’s disease (AD), occur due to an accumulation of aggregation-prone proteins, which results in neuronal death. Studies in animal and cell models show that reducing t
Externí odkaz:
https://doaj.org/article/025cf5e3def14b5b85e8e1ea105c7f8c
Publikováno v:
Autophagy Reports, Vol 1, Iss 1, Pp 247-251 (2022)
TFEB (transcription factor EB) is essential for the upregulation of gene expression required for macroautophagy/autophagy and lysosomal function. Under nutrient-rich conditions, TFEB is inactivated by MTOR (mechanistic target of rapamycin kinase) com
Externí odkaz:
https://doaj.org/article/b97ada8ca43847e287dcfd427d7db6f3
Autor:
Sai Srinivas Panapakkam Giridharan, Guangming Luo, Pilar Rivero-Rios, Noah Steinfeld, Helene Tronchere, Amika Singla, Ezra Burstein, Daniel D Billadeau, Michael A Sutton, Lois S Weisman
Publikováno v:
eLife, Vol 11 (2022)
Cell surface receptors control how cells respond to their environment. Many cell surface receptors recycle from endosomes to the plasma membrane via a recently discovered pathway, which includes sorting-nexin SNX17, Retriever, WASH, and CCC complexes
Externí odkaz:
https://doaj.org/article/7c35c8cb7b114934a237748c8f78a216
Autor:
Pilar Rivero-Ríos, Takao Tsukahara, Tunahan Uygun, Alex Chen, Garrett D. Chavis, Sai Srinivas Panapakkam Giridharan, Shigeki Iwase, Michael A. Sutton, Lois S. Weisman
Publikováno v:
Journal of Cell Biology. 222
Trafficking of cell-surface proteins from endosomes to the plasma membrane is a key mechanism to regulate synaptic function. In non-neuronal cells, proteins recycle to the plasma membrane either via the SNX27-Retromer-WASH pathway, or via the recentl
Autor:
Ismael Al-Ramahi, Sai Srinivas Panapakkam Giridharan, Yu-Chi Chen, Samarjit Patnaik, Nathaniel Safren, Junya Hasegawa, Maria de Haro, Amanda K Wagner Gee, Steven A Titus, Hyunkyung Jeong, Jonathan Clarke, Dimitri Krainc, Wei Zheng, Robin F Irvine, Sami Barmada, Marc Ferrer, Noel Southall, Lois S Weisman, Juan Botas, Juan Jose Marugan
Publikováno v:
eLife, Vol 6 (2017)
The discovery of the causative gene for Huntington’s disease (HD) has promoted numerous efforts to uncover cellular pathways that lower levels of mutant huntingtin protein (mHtt) and potentially forestall the appearance of HD-related neurological d
Externí odkaz:
https://doaj.org/article/da11075a98b347ab84cdded4b0780b44
Autor:
Samuel S. Pappas, Juan Bonifacino, Adrian Danek, William T. Dauer, Mithu De, Lucia De Franceschi, Gilbert DiPaolo, Robert Fuller, Volker Haucke, Andreas Hermann, Benoit Kornmann, Bernhard Landwehrmeyer, Johannes Levin, Aaron M. Neiman, Dobrila D. Rudnicki, Ody Sibon, Antonio Velayos-Baeza, Jan J. Vonk, Ruth H. Walker, Lois S. Weisman, Roger L. Albin
Publikováno v:
Tremor and Other Hyperkinetic Movements, Vol 7 (2017)
Chorea-Acanthocytosis (ChAc) is a rare hereditary neurological disorder characterized by abnormal movements, red blood cell pathology, and progressive neurodegeneration. Little is understood of the pathogenesis of ChAc and related disorders (collecti
Externí odkaz:
https://doaj.org/article/a53376afb1d64e0ca424ee28d941ea19
Autor:
Jason P. Chua, Karan Bedi, Michelle T. Paulsen, Mats Ljungman, Elizabeth M.H. Tank, Erin S. Kim, Jonathon P. McBride, Jennifer M. Colón-Mercado, Michael E. Ward, Lois S. Weisman, Sami J. Barmada
Publikováno v:
Curr Biol
Autophagy is a conserved, multi-step process of capturing proteolytic cargo in autophagosomes for lysosome degradation. The capacity to remove toxic proteins that accumulate in neurodegenerative disorders attests to the disease-modifying potential of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::defd0dc45c540134fd9f997a9b759687
https://europepmc.org/articles/PMC9233098/
https://europepmc.org/articles/PMC9233098/
Autor:
Lois S. Weisman, Sai Srinivas Panapakkam Giridharan, Guangming Luo, Pilar Rivero‐Rios, Noah Steinfeld, Helene Tronchere, Amika Singla, Ezra Burstein, Daniel D. Billadeau, Michael A. Sutton
Publikováno v:
The FASEB Journal. 36
Publikováno v:
Molecular Biology of the Cell. 33
Transcriptional factor EB (TFEB) is a master regulator of genes required for autophagy and lysosomal function. The nuclear localization of TFEB is blocked by the mechanistic target of rapamycin complex 1 (mTORC1)-dependent phosphorylation of TFEB at
Autor:
Yui Jin, Natsuko Jin, Yu Oikawa, Ron Benyair, Michiko Koizumi, Thomas E Wilson, Yoshinori Ohsumi, Lois S Weisman
Publikováno v:
EMBO Rep
The vacuole/lysosome plays essential roles in the growth and proliferation of many eukaryotic cells via the activation of target of rapamycin complex 1 (TORC1). Moreover, the yeast vacuole/lysosome is necessary for progression of the cell division cy