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Expression of Bile Acid Transporting Proteins in Barrett's Esophagus and Esophageal Adenocarcinoma

Autor: Gareth J.S. Jenkins, Harris Bernstein, George S. Watts, Carol Bernstein, Hana Holubec, Claire M. Payne, Richard E. Sampliner, Lois Ramsey, Harinder S. Garewal, Anil Prasad, Katerina Dvorak

Publikováno v: The American Journal of Gastroenterology. 104:302-309

Barrett's esophagus (BE) is a metaplastic lesion characterized by replacement of the normal squamous epithelium by columnar intestinal epithelium containing goblet cells. It is speculated that this process is an adaptation to protect cells from compo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07b80f1b886df49ce55f8a24d8e754e4
https://doi.org/10.1038/ajg.2008.85

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Activation of the Interleukin-6/STAT3 Antiapoptotic Pathway in Esophageal Cells by Bile Acids and Low pH: Relevance to Barrett's Esophagus

Autor: Katerina Dvorak, Sylvan B. Green, Lois Ramsey, Richard E. Sampliner, Harinder S. Garewal, Harris Bernstein, Barbora Dvorakova, Anil Prasad, Bohuslav Dvorak, Melissa Chavarria, Hana Holubec, Cara L. Crowley-Weber, Claire M. Payne, Carol Bernstein

Publikováno v: Clinical Cancer Research. 13:5305-5313

Objectives: The molecular factors contributing to the development of Barrett's esophagus (BE) are unclear. Our previous studies showed that BE tissues secrete interleukin-6 (IL-6) and express proteins associated with IL-6 signaling, including IL-6 re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40409f5f7a5eb3c7c6eaff8ef339540f
https://doi.org/10.1158/1078-0432.ccr-07-0483

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Bile acids in combination with low pH induce oxidative stress and oxidative DNA damage: relevance to the pathogenesis of Barrett's oesophagus

Autor: Katerina Dvorak, Naihsuan C. Guy, Melissa Chavarria, Sylvan B. Green, Richard E. Sampliner, Carol Bernstein, Harinder S. Garewal, Lois Ramsey, Harris Bernstein, Barbora Dvorakova, Claire M. Payne, Amanda Condon, Hana Holubec, Anil Prasad

Publikováno v: Gut. 56:763-771

Background: Barrett’s oesophagus is a premalignant condition associated with an increased risk for the development of oesophageal adenocarcinoma (ADCA). Previous studies indicated that oxidative damage contributes to the development of ADCA. Object

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::635792183b87d68e045a6d2047922277
https://doi.org/10.1136/gut.2006.103697

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Abnormal Expression of Biomarkers in Incompletely Ablated Barrett???s Esophagus

Autor: Harris Bernstein, Anil Prasad, Lois Ramsey, Ronnie Fass, Harinder S. Garewal, Claire M. Payne, Katerina Dvorak, Richard E. Sampliner

Publikováno v: Annals of Surgery. 244:1031-1036

The aim of this study was to evaluate expression of cancer risk-associated biomarkers in columnar epithelium at squamocolumnar junctions produced by an ablation procedure and proton pump inhibitors in incompletely ablated Barrett's esophagus (BE) pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91a09a989447d28b591f957aef43243c
https://doi.org/10.1097/01.sla.0000224913.19922.7e

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Reduced Pms2 Expression in Non-Neoplastic Flat Mucosa From Patients With Colon Cancer Correlates With Reduced Apoptosis Competence

Autor: Harinder S. Garewal, Lois Ramsey, Megan Wilson, Anil Prasad, Carol Bernstein, Harris Bernstein, Hana Holubec, Claire M. Payne, James Warneke, Katerina Dvorakova

Publikováno v: Applied Immunohistochemistry & Molecular Morphology. 14:166-172

Pms2 protein is a component of the DNA mismatch repair complex responsible both for post-replication correction of DNA nucleotide mispairs and for early steps in apoptosis. Germline mutations in DNA mismatch repair genes give rise to hereditary non-p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1f45216a1ee5187311f2210fb2cac92
https://doi.org/10.1097/01.pai.0000170533.61579.b9

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Unique dietary-related mouse model of colitis

Autor: Hana Holubec, Natalia A. Ignatenko, Karen A. Blohm-Mangone, David G. Besselsen, Lois Ramsey, Harris Bernstein, Monique Dall'Agnol, Harinder S. Garewal, Claire M. Payne, Katerina Dvorak, Jose L. Padilla-Torres, Eugene W. Gerner, Haiyan Cui, Carol Bernstein

Publikováno v: Inflammatory Bowel Diseases. 12:278-293

Background: A high-fat diet is a risk factor for the development of inflammatory bowel disease (IBD) in humans. Deoxycholate (DOC) is increased in the colonic contents in response to a high-fat diet. Thus, an elevated level of DOC in the colonic lume

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9ac98c61c86d30c08152788c7e4a3ae
https://doi.org/10.1097/01.mib.0000209789.14114.63

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Increased Expression and Secretion of Interleukin-6 in Patients with Barrett’s Esophagus

Autor: Hana Holubec, Anil Prasad, Harris Bernstein, Richard E. Sampliner, Katerina Dvorakova, Bohuslav Dvorak, Harinder S. Garewal, Ronnie Fass, Jessica A. Dominguez, Claire M. Payne, Haiyan Cui, Lois Ramsey, Carol Bernstein

Publikováno v: Clinical Cancer Research. 10:2020-2028

Purpose: Barrett’s esophagus (BE) is a common premalignant lesion of the distal part of the esophagus that arises as a consequence of chronic duodenogastroesophageal reflux. Interleukin (IL)-6 is a pleiotropic cytokine that regulates immune defense

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::532b8764848ca8b6f776b26642a971ba
https://doi.org/10.1158/1078-0432.ccr-0437-03

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Deoxycholate, an Endogenous Tumor Promoter and DNA Damaging Agent, Modulates BRCA-1 Expression in Apoptosis-Sensitive Epithelial Cells: Loss of BRCA-1 Expression in Colonic Adenocarcinomas

Autor: Harris Bernstein, Ryan B. Chirnomas, Brandon D. Jeffy, Carol Bernstein, Donato F. Romagnolo, Lois Ramsey, Hana Holubec, Claire M. Payne, Achyut K. Bhattacharyya, James Warneke, Harinder S. Garewal, Kathleen Kunke, Jennifer Ku

Publikováno v: Nutrition and Cancer. 46:82-92

Deoxycholate, a bile salt present at high levels in the colonic lumen of individuals on a high-fat diet, is a promoter of colon cancer. Deoxycholate also causes DNA damage. BRCA-1 functions in repair of DNA and in induction of apoptosis. We show that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2d63e8258d5193d0f00cab469c318ef
https://doi.org/10.1207/s15327914nc4601_11

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[Untitled]

Autor: Lois Ramsey, Carol Bernstein, Claire M. Payne, Nancy K Hart, Harinder S. Garewal, Ronnie Fass, Harris Bernstein

Publikováno v: Digestive Diseases and Sciences. 48:197-202

We assessed the immunohistochemical (IHC) staining patterns of three commercially available COX-2 antibodies in human tissues. The location of positive stain in sequential serial 4-μ sections of formalin fixed, paraffin embedded tissue differed cons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::658be11cdbcc7f665f102cd9ab21eb1c
https://doi.org/10.1023/a:1021871423154

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Clinical experience with the micronucleus assay

Autor: Jay O. Boyle, George E. Kaugars, Harinder S. Garewal, Lois Ramsey

Publikováno v: Journal of Cellular Biochemistry. 53:206-212

Because of the logistical and practical problems that make cancer prevention trials using cancer incidence as an endpoint virtually impossible to conduct for the majority of cancer types, there is a desperate need for valid intermediate markers of ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f442236917b34f422a833eed4edf76d8
https://doi.org/10.1002/jcb.240531031

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