Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Lois Mayton"'
Autor:
Bin Wu, Weiming Gong, Haiying Yu, Shang-You Yang, Lois Mayton, Paul H. Wooley, Richard E. Costello
Publikováno v:
Journal of Orthopaedic Research. 25:603-611
We examined a novel mouse model of wear debris-induced prosthesis instability and osteolysis, and its application for the evaluation of therapy. A stainless steel or titanium-alloy pin was implanted into the proximal tibia to form a contiguous surfac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ed5937163bfd29fd9aa206b9767af65
https://doi.org/10.1002/jor.20342
https://doi.org/10.1002/jor.20342
Publikováno v:
Annals of the Rheumatic Diseases. 62:707-714
Background: Therapeutic strategies to block tumour necrosis factor α (TNFα) activity in experimental autoimmune arthritis models and rheumatoid arthritis (RA) have proved highly successful, and provide sustained beneficial effects. Objective: To ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f586fd29371eb8433b7026d416f6e8f6
https://doi.org/10.1136/ard.62.8.707
https://doi.org/10.1136/ard.62.8.707
Publikováno v:
Arthritis & Rheumatism. 46:2514-2523
Objective Osteoprotegerin (OPG), a natural negative regulator of osteoclastogenesis and bone resorption, may be a potential therapeutic agent for treatment of osteolysis-associated prosthetic joint loosening. Using an in vivo adeno-associated virus (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fac106a1437eb814129327047bf83d0
https://doi.org/10.1002/art.10527
https://doi.org/10.1002/art.10527
Publikováno v:
Journal of Orthopaedic Research. 20:1031-1037
There is considerable evidence that orthopaedic wear debris plays a crucial role in the pathology of aseptic loosening of joint prostheses. This study examined the effect of inflammatory membranes stimulated with methyl methacrylate and polyethylene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8262cb06c45b5b218eb32c6eca2095f2
https://doi.org/10.1016/s0736-0266(02)00019-0
https://doi.org/10.1016/s0736-0266(02)00019-0
Publikováno v:
Biotechnic & Histochemistry. 70:12-18
Ethylenediaminetetraacetic acid (EDTA) solution is used to decalcify bone specimens for histological examination. Sodium hydroxide (NaOH) has been used to dissolve EDTA and to bring EDTA solutions to neutral pH. This solution, however, requires sever
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20146d8bfef6d2f1f00c05af48817298
https://doi.org/10.3109/10520299509108310
https://doi.org/10.3109/10520299509108310
Autor:
Ben D. Chen, JuanJie Ren, Weiping Ren, Xin Peng, Dongzi Yu, Bin Wu, Lois Mayton, Paul H. Wooley
Publikováno v:
Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 24(2)
Up to 20% of patients with total joint arthroplasty will develop radiographic evidence of aseptic loosening (AL), which most likely results from an inflammatory response to billions of wear debris shed from the implant. Our previous work has demonstr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af1e3a83c5339edb03bb958a9b0209d1
https://pubmed.ncbi.nlm.nih.gov/16435361
https://pubmed.ncbi.nlm.nih.gov/16435361
Autor:
Lois Mayton, P. Mukherjee, Bin Wu, Christopher H. Evans, Shang-You Yang, Paul H. Wooley, Paul D. Robbins
Publikováno v:
Gene therapy. 11(5)
The current study evaluated the protective effects of anti-inflammatory cytokine gene transfer on osteolysis provoked by orthopedic biomaterial particles using a murine model of inflammatory bone loss. A section of bone was surgically implanted into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60ed947392b9dea6134c65e868734a23
https://pubmed.ncbi.nlm.nih.gov/14724688
https://pubmed.ncbi.nlm.nih.gov/14724688
Transgenic deficiency in interferon gamma (IFNgamma) or IFNgamma receptor makes resistant strains of mice bearing H-2(b) or H-2(d) susceptible to collagen induced arthritis (CIA).To determine whether the escape from regulation of disease susceptibili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51b539a229de7678b0ebd1a7d7d112bf
https://europepmc.org/articles/PMC1754310/
https://europepmc.org/articles/PMC1754310/
Publikováno v:
Journal of biomedical materials research. Part A. 64(3)
It is recognized that the chronic inflammation in peri-prosthetic tissue that contributes to implant failure frequently is provoked by the presence of wear debris. Some wear debris is inevitable because of the nature of the prosthesis, but not all pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18680958faddd73c35b0841918c94cf1
https://pubmed.ncbi.nlm.nih.gov/12579559
https://pubmed.ncbi.nlm.nih.gov/12579559
Publikováno v:
Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 51(7)
Objective: This study examined anti-inflammatory gene therapy to ameliorate tissue responses to ultra high molecular weight polyethylene (UHMWPE) particles in the murine air pouch.¶Methods: Retroviruses encoding human interleukin-1 receptor antagoni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76416dcf4579ed5b3bae6aa9f0987950
https://pubmed.ncbi.nlm.nih.gov/12146725
https://pubmed.ncbi.nlm.nih.gov/12146725