Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Lois L. Carl"'
Autor:
JuFang Wang, Belinda A. Ahlers, Xue-Qian Zhang, Lois L. Carl, Jianliang Song, Joseph Y. Cheung
Publikováno v:
American Journal of Physiology-Cell Physiology. 296:C911-C921
Phospholemman (PLM) belongs to the FXYD family of small ion transport regulators. When phosphorylated at Ser68, PLM inhibits cardiac Na+/Ca2+exchanger (NCX1). We previously demonstrated that the cytoplasmic tail of PLM interacts with the proximal int
Autor:
JuFang Wang, Xue-Qian Zhang, Belinda A. Ahlers, Lois L. Carl, Jianliang Song, Lawrence I. Rothblum, Richard C. Stahl, David J. Carey, Joseph Y. Cheung
Publikováno v:
Journal of Biological Chemistry. 281:32004-32014
Autor:
Joseph Y. Cheung, George M. Tadros, Jianliang Song, Lawrence I. Rothblum, Belinda A. Ahlers, Lois L. Carl, Xue-Qian Zhang, JuFang Wang
Publikováno v:
Journal of Applied Physiology. 98:2169-2176
Previous studies in adult myocytes isolated from rat hearts 3 wk after myocardial infarction (MI) demonstrated abnormal contractility and intracellular Ca2+ concentration ([Ca2+]i) homeostasis and decreased sarcoplasmic reticulum Ca2+-ATPase (SERCA2)
Autor:
Xue-Qian Zhang, Lawrence I. Rothblum, Belinda A. Ahlers, Lois L. Carl, J. Randall Moorman, Amy L. Tucker, J. Paul Mounsey, Richard C. Stahl, Jianliang Song, Joseph Y. Cheung, JuFang Wang
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 288:H2342-H2354
Overexpression of phospholemman (PLM) in normal adult rat cardiac myocytes altered contractile function and cytosolic Ca2+concentration ([Ca2+]i) homeostasis and inhibited Na+/Ca2+exchanger (NCX1). In addition, PLM coimmunoprecipitated and colocalize
Autor:
Amy L. Tucker, Xue-Qian Zhang, Belinda A. Ahlers, Jianliang Song, Anwer Qureshi, M. Ayoub Mirza, Thomas S. Zhang, Lois L. Carl, Joseph Y. Cheung, J. Paul Mounsey, J. Randall Moorman, Lawrence I. Rothblum
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 286:H1322-H1330
Phospholemman (PLM) expression was increased in rat hearts after myocardial infarction (MI). Overexpression of PLM in normal adult rat cardiac myocytes altered contractile function and cytosolic Ca2+concentration ([Ca2+]i) homeostasis in a manner sim
Autor:
David J. Carey, Xue-Qian Zhang, Jianliang Song, Lois L. Carl, Richard C. Stahl, Anwer Qureshi, Qiang Tian, Joseph Y. Cheung, Lawrence I. Rothblum
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 284:H225-H233
Previous studies have shown that overexpression of phospholemman (PLM) affected contractile function and Ca2+homeostasis in adult rat myocytes. We tested the hypothesis that PLM modulated Na+/Ca2+exchanger (NCX1) activity. PLM was overexpressed in ad
Autor:
Xue-Qian Zhang, Jianliang Song, Weixing Shi, Lois L. Carl, Joseph Y. Cheung, Qiang Tian, Anwer Qureshi
Publikováno v:
Journal of Applied Physiology. 93:1310-1317
The effects of 6–8 wk of high-intensity sprint training (HIST) on rat myocyte contractility and intracellular Ca2+concentration ([Ca2+]i) transients were investigated. Compared with sedentary (Sed) myocytes, HIST induced a modest (5%) but significa
Autor:
Joseph Y. Cheung, Lois L. Carl, George M. Tadros, Qiang Tian, Jonathan Lytton, Lawrence I. Rothblum, Jianliang Song, Jeremy Dunn, Xue-Qian Zhang
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 283:H1616-H1626
Postmyocardial infarction (MI) rat myocytes demonstrated depressed Na+/Ca2+exchange (NCX1) activity, altered contractility, and intracellular Ca2+ concentration ([Ca2+]i) transients. We investigated whether NCX1 downregulation in normal myocytes resu
Autor:
Jianliang Song, Xue-Qian Zhang, Lawrence I. Rothblum, Lois L. Carl, Joseph Y. Cheung, Anwer Qureshi
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 283:H576-H583
Previous studies showed increased phospholemman (PLM) mRNA after myocardial infarction (MI) in rats (Sehl PD, Tai JTN, Hillan KJ, Brown LA, Goddard A, Yang R, Jin H, and Lowe DG. Circulation 101: 1990–1999, 2000). We tested the hypothesis that, in
Autor:
Jianliang Song, Joseph Y. Cheung, JuFang Wang, Xue-Qian Zhang, Amy L. Tucker, Lawrence I. Rothblum, Belinda A. Ahlers, Lois L. Carl, J. Randall Moorman
Publikováno v:
Annals of the New York Academy of Sciences. 1099
Phospholemman (PLM) is the first sequenced member of the FXYD family of regulators of ion transport. The mature protein has 72 amino acids and consists of an extracellular N terminus contain- ing the signature FXYD motif, a single transmembrane domai