Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Lois Kline"'
Autor:
Nicole Teusch, Mausumee Guha, Lois Kline, Jean Paul Mira, Paul J. Godowski, Nigel Mackman, Laurence Arbibe, Richard J. Ulevitch, Ulla G. Knaus
Publikováno v:
Nature Immunology. 1:533-540
Mammalian Toll-like receptors (TLRs) are expressed on innate immune cells and respond to the membrane components of Gram-positive or Gram-negative bacteria. When activated, they convey signals to transcription factors that orchestrate the inflammator
Autor:
Richard J. Ulevitch, Hermann Gram, Colleen Fearns, Jiahuai Han, Mauro Zurini, F Di Padova, Lois Kline
Publikováno v:
Journal of Leukocyte Biology. 67:705-711
The p38 family of mitogen-activated protein kinases is believed to mediate a variety of leukocyte responses to pro-inflammatory stimuli. There are four members of the p38 family, and although activation of the different members has been studied in tr
Autor:
J. D. Lee, Peter S. Tobias, Vladimir V. Kravchenko, Richard J. Ulevitch, Jérôme Pugin, Lois Kline
Publikováno v:
Infection and Immunity. 66:1174-1180
CD14 is a glycosylphosphatidylinositol (GPI)-anchored membrane glycoprotein which functions as a receptor on myeloid cells for ligands derived from microbial pathogens such as lipopolysaccharide (LPS). We have studied the importance of the GPI tail o
Publikováno v:
Journal of leukocyte biology. 71(3)
Among the bacterial products known to activate the innate immune ‘1system is bacterial DNA. This activity resides within the nonmethylated CpG motifs of the DNA and is recapitulated using appropriate synthetic CpG containing oligodeoxynucleotides (
Autor:
Peter S. Tobias, Jérôme Pugin, Richard J. Ulevitch, Katrin Soldau, J. D. Lee, Lois Kline, Deborah E. Schiff
Publikováno v:
Journal of leukocyte biology. 62(6)
THP-l-derived cell lines were stably transfected with constructs encoding glycophosphatidylinositol (GPI) -anchored or transmembrane forms of human CD14. CD14 expression was associated with enhanced phagocytosis of serum (heat-inactivated) -opsonized