Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Lois K. Chenard"'
Autor:
Ludivine Moine, Bruce N. Rogers, Mark L. Weber, Karen Tse, Sheri L. Snow, Susan E. Drozda, Karen Baker, John A. Lowe, Kevin A. Serpa, Katherine Schuyten, Jennifer E. Davoren, Rong Suobao, Ann S. Wright, Shari L. DeNinno, Michelle Marie Claffey, Allen J. Duplantier, Christopher Ryan Butler, Brian P. Boscoe, Alan J. Clark, Polina Stolyar, Robert J. Mather, Lois K. Chenard, Haojing Rong, Gaurav Arora, Matthew R. Reese, Tammy Whisman, Lei Zhang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:4941-4944
Facilitating activation, or delaying inactivation, of the native Kv7 channel reduces neuronal excitability, which may be beneficial in controlling spontaneous electrical activity during epileptic seizures. In an effort to identify a compound with suc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47d5703f96a7e503af07e95a710ca422
https://doi.org/10.1016/j.bmcl.2015.04.074
https://doi.org/10.1016/j.bmcl.2015.04.074
Publikováno v:
ACS Combinatorial Science. 17:653-657
A sulfur-functionalized aminoacrolein derivative is used for the efficient and selective synthesis of heterocyclic sulfonyl chlorides, sulfonyl fluorides, and sulfonamides. The development of a 3-step parallel medicinal chemistry (PMC) protocol for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::586e42128d21ca1abb08c7e3992a1cb0
https://doi.org/10.1021/acscombsci.5b00120
https://doi.org/10.1021/acscombsci.5b00120
Autor:
Patrick Robert Verhoest, Susan E. Drozda, Kenneth R. Zasadny, Emily Miller, Lei Zhang, Kari R. Fonseca, Gabriela Barreiro, Patrick Trapa, Michelle Marie Claffey, Julie Cianfrogna, Marc B. Skaddan, Deborah L. Smith, Margaret M. Zaleska, Joshua R. Dunetz, Christopher L. Shaffer, Jessica Mancuso, Isao Sakurada, Gayatri Balan, Jamison B. Tuttle, Lois K. Chenard, Bruce N. Rogers, Matthew R. Reese, Antonia F. Stepan, Paul Galatsis, Brian P. Boscoe, Daniel P. Walker, Sarah Grimwood, Ann S. Wright, John T. Lazzaro, Karen J. Coffman, Laigao Chen
Publikováno v:
Journal of Medicinal Chemistry. 57:861-877
A novel series of pyrazolopyrazines is herein disclosed as mGluR5 negative allosteric modulators (NAMs). Starting from a high-throughput screen (HTS) hit (1), a systematic structure-activity relationship (SAR) study was conducted with a specific focu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a87c83f67fb92d09c6e15f29a119306f
https://doi.org/10.1021/jm401622k
https://doi.org/10.1021/jm401622k
Autor:
Carol B. Fox, Spiros Liras, Douglas S. Chapin, Frederick R. Nelson, Jayvardhan Pandit, Xinjun Hou, Christopher John Helal, John M. Humphrey, Christopher J. Schmidt, Thomas Allen Chappie, Kimberly F. Fennell, Frank S. Menniti, Zhijun Kang, Julia Cianfrogna, Judith A. Siuciak, Mary C. MacDougall, Kari R. Fonseca, Rebecca E. O’Connor, Lois K. Chenard, Eric S. Marr, Lorraine A. Lebel, Laura McDowell, Robert D. Williams
Publikováno v:
Journal of Medicinal Chemistry. 54:4536-4547
Utilizing structure-based virtual library design and scoring, a novel chimeric series of phosphodiesterase 10A (PDE10A) inhibitors was discovered by synergizing binding site interactions and ADME properties of two chemotypes. Virtual libraries were d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9470cb95f70a63260200b088b6fe12a3
https://doi.org/10.1021/jm2001508
https://doi.org/10.1021/jm2001508
Autor:
Christopher J. Schmidt, Frank S. Menniti, Kari R. Fonseca, Spiros Liras, Robert D. Williams, Michelle Vanase-Frawley, Frederick R. Nelson, Christopher John Helal, Eric S. Marr, Patrick Robert Verhoest, Xinjun Hou, Shenping Liu, Lois K. Chenard, Michael L. Corman, Anne W. Schmidt, Caroline Proulx-Lafrance, Robin J. Kleiman
Publikováno v:
Journal of Medicinal Chemistry. 52:7946-7949
By use of chemical enablement and prospective design, a novel series of selective, brain penetrant PDE9A inhibitors have been identified that are capable of producing in vivo elevations of brain cGMP.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36f96537fb0d514fc2467932c7482e6c
https://doi.org/10.1021/jm9015334
https://doi.org/10.1021/jm9015334
Autor:
Veronica Reinhart, Susan M. Lotarski, Stefanus J. Steyn, Jennifer E. Davoren, Lei Zhang, Erik Alphie Lachapelle, Deane M. Nason, Michael Eric Green, Keith Dlugolenski, Anthony R. Harris, Jiangli Yan, Sarah Grimwood, Michelle R. Garnsey, Chewah Lee, Dennis P. Anderson, John T. Lazzaro, R. Scott Obach, Damien Webb, Lois K. Chenard, Jeremy R. Edgerton, Michael Aaron Brodney, Romelia Salomon-Ferrer, Gregory W. Kauffman, Steven Victor O'neil
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(2)
Selective activation of the M1 receptor via a positive allosteric modulator (PAM) is a new approach for the treatment of the cognitive impairments associated with schizophrenia and Alzheimer's disease. A novel series of azaindole amides and their key
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c3a645b21d1863c52f9d4f7a6024733
https://pubmed.ncbi.nlm.nih.gov/26631313
https://pubmed.ncbi.nlm.nih.gov/26631313
Autor:
John B. Etienne, Michael P. DeNinno, Scott P. Kennedy, Jimmy Kong, Roger J. Hill, Hiroko Masamune, Kenneth J. DiRico, Cynthia Eller, W. Ross Tracey, Jeanene E. Tickner, Joseph J. Oleynek, Delvin R. Knight, Lois K. Chenard
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(9)
Using a combination of parallel and directed synthesis, the discovery of a highly potent and selective series of adenosine A3 agonists was achieved. High aqueous solubility, required for the intended parenteral route of administration, was achieved b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad564239b2f7c1c057babe0e7df9a8c9
https://pubmed.ncbi.nlm.nih.gov/16464581
https://pubmed.ncbi.nlm.nih.gov/16464581
Autor:
Michael P. DeNinno, John B. Etienne, Jeanene E. Tickner, Kenneth J. DiRico, W. Ross Tracey, Roger J. Hill, Scott P. Kennedy, Jimmy Kong, Lois K. Chenard, Cynthia Eller, Hiroko Masamune, Joseph J. Oleynek, Delvin R. Knight
Publikováno v:
Journal of medicinal chemistry. 46(3)
Selective adenosine A(3) agonists have potential utility for the prevention of perioperative myocardial ischemic injury. Herein, we report on the discovery and synthesis of compound 7. This amino nucleoside agonist possesses unprecedented levels of s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97fe97d36c3f1729a7fcc3618cbf2430
https://pubmed.ncbi.nlm.nih.gov/12540233
https://pubmed.ncbi.nlm.nih.gov/12540233