Výsledky vyhledávání - "Lois J. Haupt"

In vitroinhibition of human liver cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT) enzymes by rose bengal: system-dependent effects on inhibitory potential

Autor: David B. Buckley, E. A. Wachter, Jamie Singer, Jennifer R. Horkman, Faraz Kazmi, Brian D. Smith, Lois J. Haupt

Publikováno v: Xenobiotica. 44:606-614

1. Rose bengal (4,5,6,7-tetrachloro-2',4',5',7'-tetraiodofluorescein) is being developed for the treatment of cutaneous melanoma and hepatocellular carcinoma. Interestingly, rose bengal can generate singlet oxygen species upon exposure to light. 2. W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4c121d2be2ffd1df9318d5de0267f99
https://doi.org/10.3109/00498254.2013.878814

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An in Vitro Evaluation of the Victim and Perpetrator Potential of the Anticancer Agent Laromustine (VNP40101M), Based on Reaction Phenotyping and Inhibition and Induction of Cytochrome P450 Enzymes

Autor: Dan Brobst, Brandy L. Paris, Florence Ndikum-Moffor, Etsuko Usuki, Andrew Parkinson, Jennifer Skibbe, Ivan King, Brian W. Ogilvie, Alaa-Eldin F Nassar, Lois J. Haupt, Rebecca Campbell

Publikováno v: Drug Metabolism and Disposition. 37:1922-1930

Laromustine (VNP40101M, also known as Cloretazine) is a novel sulfonylhydrazine alkylating (anticancer) agent. Laromustine generates two types of reactive intermediates: 90CE and methylisocyanate. When incubated with rat, dog, monkey, and human liver

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95f609c798bda1ce2ce5e1408090a5ac
https://doi.org/10.1124/dmd.109.027516

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The Reliability of Estimating Ki Values for Direct, Reversible Inhibition of Cytochrome P450 Enzymes from Corresponding IC50 Values: A Retrospective Analysis of 343 Experiments

Autor: Faraz Kazmi, Lois J. Haupt, David B. Buckley, Brandy L. Paris, Brian W. Ogilvie, Andrew Parkinson, Brian D. Smith, Oliver T. Parkinson, Sarah Leatherman

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 43(11)

In the present study, we conducted a retrospective analysis of 343 in vitro experiments to ascertain whether observed (experimentally determined) values of Ki for reversible cytochrome P450 (P450) inhibition could be reliably predicted by dividing th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83577b8d91e0308ed5a55861dca943fc
https://pubmed.ncbi.nlm.nih.gov/26354951

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