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Immunization With Mutantp53- andK-ras–Derived Peptides in Cancer Patients: Immune Response and Clinical Outcome

Autor: Michael Stipanov, Jay A. Berzofsky, M. Charles Smith, I. Frank Ciernik, Denise Kavanaugh, Charley Carter, Elizabeth J. Read, David Contois, Morris I. Kelsey, Sorena Nadaf, Burkhardt Seifert, Lois E. Top, John D. Minna, C. David Pendleton, Bruce E. Johnson, Michael J. Kelley, David P. Carbone, Jay Greenblatt, V. Ellen Maher

Publikováno v: Journal of Clinical Oncology. 23:5099-5107

PurposeTo determine the ability to induce tumor-specific immunity with individual mutant K-ras–or p53-derived peptides and to monitor clinical outcome.Patients and MethodsPatients in varying stages of disease underwent genetic analysis for mutation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49d8c32f2572e9746b8ddbdd0c2a8991
https://doi.org/10.1200/jco.2005.03.158

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Infectious complications and immunodeficiency in patients with human T-cell lymphotropic virus I-associated adult T-cell leukemia/lymphoma

Autor: Sara Zaknoen, Claude Kasten-Sportes, Lois E. Top, Jeffrey D. White, Lydia Navarro-Román, David L. Nelson, Thomas A. Waldmann

Publikováno v: Cancer. 75:1598-1607

Background. Adult T-cell leukemia/lymphoma (ATL) is a malignancy of mature T-cells occurring in patients infected with the human T-cell lymphotropic virus-I. These patients frequently develop a variety of infections throughout their disease course. M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::01a659c63e2900a57e6d7d07470b8ff5
https://doi.org/10.1002/1097-0142(19950401)75:7<1598::aid-cncr2820750708>3.0.co

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The interleukin-2 receptor: a target for monoclonal antibody treatment of human T-cell lymphotrophic virus I-induced adult T-cell leukemia

Autor: Ivan D. Horak, Sara Zaknoen, Claude Kasten-Sportes, Richard N. Bamford, Erich Roessler, Lois E. Top, Angus Grant, T. A. Waldmann, Jeffrey D. White, Carolyn K. Goldman

Publikováno v: Blood. 82:1701-1712

Adult T-cell leukemia (ATL) is a malignancy of mature lymphocytes caused by the retrovirus human T-cell lymphotrophic virus-I (HTLV-I). It is an aggressive leukemia with an overall mortality rate of 50% within 5 months; no conventional chemotherapy r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cf4b2750dd8e1e0776e440a17232bfa
https://doi.org/10.1182/blood.v82.6.1701.1701

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Preclinical and phase I clinical trial of blockade of IL-15 using Mikβ1 monoclonal antibody in T cell large granular lymphocyte leukemia

Autor: Margaret R. Brown, Cathryn C. Lee, Thomas A. Fleisher, John E. Janik, Michael N. Petrus, Thomas A. Waldmann, Jeffrey D. White, Lois E. Top, Wendy Gao, Mitsuru Tsudo, John C. Morris, Carolyn K. Goldman, Bonita R. Bryant

Twelve patients with T cell large granular lymphocyte leukemia and associated hematocytopenia were treated in a phase I dose-escalation trial with the murine monoclonal antibody Mikβ1. Mikβ1 identifies CD122, the β-subunit shared by the IL-2 and I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28b4c656c97586cbb678bb37a791e523
https://europepmc.org/articles/PMC1326174/

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The combination of zidovudine and interferon alpha-2B in the treatment of adult T-cell leukemia/lymphoma

Autor: Thomas A. Waldmann, Michael Derby, Donn M. Stewart, Thomas A. Fleisher, Lois E. Top, Gilian Wharfe, Barrie Hanchard, David L. Nelson, Ashish Jain, Virginia E. Maher, Jeffrey D. White, Cathryn C. Lee, Donald M. Eicher, Daniel Lucy, Peta-Gay Jackson-booth, Bert Herring, Margaret Marshall, Beverley Cranston

Publikováno v: Leukemialymphoma. 40(3-4)

Adult T-cell leukemia/lymphoma (ATL) is frequently a very aggressive malignancy with a poor survival despite aggressive multiagent chemotherapy. The combination of the antiretroviral drug zidovudine (AZT) and interferon alpha (IFNalpha) has been repo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c75ad921668ae417ee18ab2514c494a
https://pubmed.ncbi.nlm.nih.gov/11426550

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Cytokine Receptor Directed Therapy with Genetically Engineered Monoclonal Antibodies Armed with Radionuclides

Autor: Carolyn K. Goldman, Jeffrey D. White, David E. Nelson, T. A. Waldmann, Lois E. Top

Publikováno v: Progress in Immunology Vol. VIII ISBN: 9783642514814

The hybridoma technique of Kohler and Milstein (1975) rekindled interest in the use of antibodies targeted to cell surface antigens to treat cancer patients. However, such monoclonal antibodies have been relatively ineffective (Catane and Longo 1989)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3e879ea34e952f1b7d3de11d406bce5e
https://doi.org/10.1007/978-3-642-51479-1_44

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The Interleukin-2 Receptor: A Target for Immunotherapy

Autor: Erich Roessler, Lois E. Top, Richard N. Bamford, Carolyn K. Goldman, Thomas A. Waldmann, Claude Kasten-Sportes, Sara Zaknoen, Angus Grant, Jeffrey D. White, Jack D. Burton, David E. Nelson, Ivan D. Horak

Publikováno v: Advances in Experimental Medicine and Biology ISBN: 9781461365006

Immune intervention began almost two centuries ago when Jenner introduced vaccination with cowpox as a means of protecting against smallpox. This form of immune intervention plays a dominant role in the prevention of human disease. Furthermore, immun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c757b0a6a5bd18b63712617c031c8b61
https://doi.org/10.1007/978-1-4615-3396-2_8

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