Výsledky vyhledávání - "Lois B. Allen"

An ELISA system for evaluating antiretroviral activity against Rauscher murine leukemia virus

Autor: Melinda G. Hollingshead, Martha J. Ross, Lois B. Allen, K.Jeanine Qualls, Jean Bailey, Louise Westbrook

Publikováno v: Antiviral Research

A system for evaluating the activity of antiviral agents against Rauscher murine leukemia virus (R-MuLV) has been developed using an enzyme linked immunosorbent assay technique. The activity of various antiviral compounds demonstrated in this assay s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9adeb8bd633a3ed06844a7b6ffc8fc57
http://europepmc.org/articles/PMC7173104

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Evaluation of anti-AIDS drugs in conventional mice implanted with a permeable membrane device containing human T cells infected with HIV

Autor: Claudy J.-P. Mullon, Karen E. Dunleavy, Lois B. Allen, Debra C. Quenelle, Kathy A. Keith, Anne D. Brazier, Beth A. Taylor, Bonnie J. Bowdon, Reginald E. Harris

Publikováno v: Antiviral Research. 35:123-129

We now report the confirmation of the work of Hollingshead et al. (1995) on development of a cell based hollow fiber (HF) system for evaluating potential anti-AIDS drugs in vivo using conventional mice rather than SCID mice. CD4+, CEM-SS cells infect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87e321b05ac9ae99f94f8992eaee3a8e
https://doi.org/10.1016/s0166-3542(97)00014-4

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Cell-Based and Biochemical Analysis of the anti-HIV Activity of Combinations of 3′-azido-3′-deoxythymidine and Analogues of TIBO

Autor: J. Germany-Decker, Larry J. Ross, P. A. J. Janssen, E. L. White, Michael A. Chirigos, Robert W. Buckheit, William M. Shannon, Lois B. Allen

Publikováno v: Antiviral Chemistry and Chemotherapy. 5:35-42

The toxicity of 3′-azido-3′-deoxythymidine (AZT) and the appearance of drug-resistant mutants in patients treated with AZT emphasizes the critical importance of the development of alternative strategies for the therapy of AIDS patients. Combinati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::20bc0ad2d1733fa2eb42252ad4885c72
https://doi.org/10.1177/095632029400500105

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Novel method for evaluating antiviral drugs against human cytomegalovirus in mice

Autor: Melinda G. Hollingshead, William M. Shannon, B. J. Toyer, Lois B. Allen, Shixiong Li, G. Arnett

Publikováno v: Antimicrobial Agents and Chemotherapy. 36:206-208

A virus-host cell system in which human cytomegalovirus-infected human cells are entrapped in agarose plugs has been developed. This model provides an inexpensive method for the in vivo evaluation (with outbred, immunocompetent mice) of antiviral dru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06ec53598d46156e36280f723ddfd53e
https://doi.org/10.1128/aac.36.1.206

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Plant-derived and semi-synthetic calanolide compounds with in vitro activity against both human immunodeficiency virus type 1 and human cytomegalovirus

Autor: Earl R. Kern, Lois B. Allen, Louise Westbrook, Michael T. Flavin, Robert W. Buckheit, Tuah R. Jenta, Christopher K. H. Tseng, Ze-Qi Xu

Publikováno v: Antiviral chemistrychemotherapy. 11(1)

Plant-derived and semi-synthetic calanolide compounds with anti-human immunodeficiency virus type 1 (HIV-1) activity were tested for anti-human cytomegalovirus (HCMV) activity in both cytopathic effect inhibition and plaque reduction assays. The resu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32bfba23113343e84170f4b1fc77bd38
https://pubmed.ncbi.nlm.nih.gov/10693651

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Failure of Castanospermine to Reduce Spleen or Serum Virus Titres in Rauscher Murine Leukaemia Virus-Infected Mice

Autor: B. J. Toyer, Louise Westbrook, Melinda G. Hollingshead, Lois B. Allen

Publikováno v: Antiviral Chemistry and Chemotherapy. 2:119-121

The effects of orally administered castanospermine (CS) and azidothymidine (AZT) on spleen and serum virus titres and on spleen weights of mice inoculated with Rauscher murine leukaemia virus (R MuLV) were evaluated. Virus titres of samples from CS-t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1da715809fc2f46cc91666024310bcc7
https://doi.org/10.1177/095632029100200208

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In vitro and in vivo enhancement of ddI activity against Rauscher murine leukemia virus by ribavirin

Autor: William M. Shannon, Melinda G. Hollingshead, Lois B. Allen, Mark N. Prichard, Anne D. Brazier, Beth A. Taylor, Louise Westbrook, Debra C. Quenelle

Publikováno v: Antiviral research. 27(3)

Ribavirin has been reported to enhance the activity of ddI against HIV. We explored this enhancement of antiviral activity in Rauscher murine leukemia virus (RMuLV) models in vitro and in vivo. The significant finding in these studies was that combin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77fef421907e6f9869942fdf5b9c118c
https://pubmed.ncbi.nlm.nih.gov/8540752

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Differential antiviral activity of two TIBO derivatives against the human immunodeficiency and murine leukemia viruses alone and in combination with other anti-HIV agents

Autor: Robert W. Buckheit, Lois B. Allen, William M. Shannon, Melinda G. Hollingshead, Paul A. J. Janssen, Julie Germany-Decker, Michael A. Chirigos

Publikováno v: AIDS research and human retroviruses. 9(11)

R82913 and R86183, two derivatives of tetrahydroimidazo[4,5,1-jk][1,4]-benzodiazepin-2(1H)-thione (TIBO), were found to potently and selectively inhibit the replication and cell killing effects of a panel of biologically diverse laboratory and clinic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9df51084a10fa782a385beed2e1cc31d
https://pubmed.ncbi.nlm.nih.gov/7508723

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Thiazolobenzimidazole: biological and biochemical anti-retroviral activity of a new nonnucleoside reverse transcriptase inhibitor

Autor: Julie Germany-Decker, Michael R. Boyd, W. Don Decker, John P. Bader, Larry J. Ross, James B. McMahon, E. Lucile White, Melinda G. Hollingshead, Lois B. Allen, Louise Westbrook, Owen S. Weislow, William M. Shannon, Robert W. Buckheit

Publikováno v: Antiviral research. 21(3)

Thiazolobenzimidazole (NSC 625487) was a highly potent inhibitor of human immunodeficiency virus-induced cell killing and viral replication in a variety of human cell lines, as well as fresh human peripheral blood lymphocytes and macrophages. The com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78b99adc0c64fab6a6dd14928353b713
https://pubmed.ncbi.nlm.nih.gov/7692815

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