Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Lois Lehman-McKeeman"'
Autor:
Zheng Yang, James Loy, Brian Poirson, Yanshan Dai, Surendran Rajendran, Shihua Xu, Vanessa Spires, Murali Gururajan, Zheng Lin, Jaren Arbanas, Stephen Carl, Samantha Pace, Yun Wang, John Mehl, Krishna Vasudevan, Thomas Spires, Ruslan Novosiadly, Shodeinde Coker, Raymond Perez, Kelly Covello, Paul Morin, Robert Graziano, Miranda Broz, Lois Lehman-McKeeman
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Pharmacokinetic/pharmacodynamic (PK/PD) modeling was performed to quantitatively integrate preclinical pharmacology and toxicology data for determining the therapeutic index (TI) of an interleukin-10 (IL-10) fragment crystallizable (Fc) fusion protei
Externí odkaz:
https://doaj.org/article/ea7bedd2c46442b79708657bc96f6c3d
Autor:
Zheng, Yang, Surendran, Rajendran, Vanessa, Spires, Brian, Poirson, Murali, Gururajan, Zheng, Lin, Jaren, Arbanas, Stanley, Krystek, James, Loy, Yuan, Cheng, Stephen, Carl, Samantha, Pace, Yun, Wang, John, Mehl, Shihua, Xu, Krishna, Vasudevan, Miranda, Broz, Lois, Lehman-McKeeman, Paul, Morin, Robert F, Graziano
Publikováno v:
Drug Metabolism and Disposition. 50:898-908
Fragment crystallizable (Fc) fusion is commonly used for extending the half-life of biotherapeutics such as cytokines. In this work, we studied the pharmacokinetics of Fc-fused interleukin-10 (IL-10) proteins that exhibited potent antitumor activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f10fbd6114f5d015011335019ef6b474
https://doi.org/10.1124/dmd.121.000799
https://doi.org/10.1124/dmd.121.000799
Autor:
Michael W, Gill, Brian J, Murphy, Peter T W, Cheng, Lakshmi, Sivaraman, Myrtle, Davis, Lois, Lehman-McKeeman
Publikováno v:
Toxicology and applied pharmacology. 438
In a Phase 2 clinical trial, BMS-986020, a lysophosphatidic acid receptor-1 (LPA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c05a729d9cdd63ca5548b19a44a3985d
https://pubmed.ncbi.nlm.nih.gov/35090952
https://pubmed.ncbi.nlm.nih.gov/35090952
Autor:
Michael W. Gill, Brian J. Murphy, Peter T.W. Cheng, Lakshmi Sivaraman, Myrtle Davis, Lois Lehman-McKeeman
Publikováno v:
Toxicology and Applied Pharmacology. 438:115885
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c5fac14cdc87fc4a6e86db3a803c4c4
https://doi.org/10.1016/j.taap.2022.115885
https://doi.org/10.1016/j.taap.2022.115885
Autor:
Hai-Yun, Xiao, Scott H, Watterson, Charles M, Langevine, Anurag S, Srivastava, Soo S, Ko, Yanlei, Zhang, Robert J, Cherney, Wei-Wei, Guo, John L, Gilmore, James E, Sheppeck, Dauh-Rurng, Wu, Peng, Li, Duraisamy, Ramasamy, Piramanayagam, Arunachalam, Arvind, Mathur, Tracy L, Taylor, David J, Shuster, Kim W, McIntyre, Ding-Ren, Shen, Melissa, Yarde, Mary Ellen, Cvijic, Anthony M, Marino, Praveen V, Balimane, Zheng, Yang, Dana M, Banas, Georgia, Cornelius, Celia J, D'Arienzo, Bethanne M, Warrack, Lois, Lehman-McKeeman, Luisa M, Salter-Cid, Jenny, Xie, Joel C, Barrish, Percy H, Carter, Alaric J, Dyckman, T G Murali, Dhar
Publikováno v:
Journal of medicinal chemistry. 59(21)
Fingolimod (1) is the first approved oral therapy for the treatment of relapsing remitting multiple sclerosis. While the phosphorylated metabolite of fingolimod was found to be a nonselective S1P receptor agonist, agonism specifically of S1P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f9eb88b5ba2b222a1d206be47d1ac90e
https://pubmed.ncbi.nlm.nih.gov/27726358
https://pubmed.ncbi.nlm.nih.gov/27726358
Autor:
Lois Lehman-McKeeman
Publikováno v:
Drugs and the Pharmaceutical Sciences ISBN: 9781574448788
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a6d969e3dc1afa2a07ab7058973f781
https://doi.org/10.1201/9780849359507.ch14
https://doi.org/10.1201/9780849359507.ch14
Autor:
Mary E. Bollard, Nancy R. Contel, Timothy M. D. Ebbels, Leon Smith, Olaf Beckonert, Glenn H. Cantor, Lois Lehman-McKeeman, Elaine C. Holmes, John C. Lindon, Jeremy K. Nicholson, Hector C. Keun
Publikováno v:
Journal of Proteome Research; Jan2010, Vol. 9 Issue 1, p59-69, 11p
Autor:
Dean A. Wacker, Jeffrey G. Varnes, Sarah E. Malmstrom, Xueying Cao, Chen-Pin Hung, Thao Ung, Ginger Wu, Ge Zhang, Eva Zuvich, Michael A. Thomas, William J. Keim, Mary Jane Cullen, Kenneth W. Rohrbach, Qinling Qu, Rangaraj Narayanan, Karen Rossi, Evan Janovitz, Lois Lehman-McKeeman, Mary F. Malley, James Devenny
Publikováno v:
Journal of Medicinal Chemistry; Mar2007, Vol. 50 Issue 6, p1365-1379, 15p