Non-competitive cyclic peptides for targeting enzyme-substrate complexes.

Autor: McAllister TE; Department of Chemistry , University of Oxford , Chemistry Research Laboratory , 12 Mansfield Road , Oxford OX1 3TA , UK . Email: akane.kawamura@chem.ox.ac.uk., Yeh TL; Department of Chemistry , University of Oxford , Chemistry Research Laboratory , 12 Mansfield Road , Oxford OX1 3TA , UK . Email: akane.kawamura@chem.ox.ac.uk., Abboud MI; Department of Chemistry , University of Oxford , Chemistry Research Laboratory , 12 Mansfield Road , Oxford OX1 3TA , UK . Email: akane.kawamura@chem.ox.ac.uk., Leung IKH; Department of Chemistry , University of Oxford , Chemistry Research Laboratory , 12 Mansfield Road , Oxford OX1 3TA , UK . Email: akane.kawamura@chem.ox.ac.uk.; School of Chemical Sciences , The University of Auckland , Private Bag 92019 , Auckland 1142 , New Zealand., Hookway ES; Botnar Research Centre , NIHR Oxford Biomedical Research Unit , University of Oxford , Windmill Road , Oxford , OX3 7LD , UK., King ONF; Department of Chemistry , University of Oxford , Chemistry Research Laboratory , 12 Mansfield Road , Oxford OX1 3TA , UK . Email: akane.kawamura@chem.ox.ac.uk., Bhushan B; Department of Chemistry , University of Oxford , Chemistry Research Laboratory , 12 Mansfield Road , Oxford OX1 3TA , UK . Email: akane.kawamura@chem.ox.ac.uk.; Division of Cardiovascular Medicine , Radcliffe Department of Medicine , University of Oxford , Wellcome Trust Centre for Human Genetics , Roosevelt Drive , Oxford OX3 7BN , UK., Williams ST; Department of Chemistry , University of Oxford , Chemistry Research Laboratory , 12 Mansfield Road , Oxford OX1 3TA , UK . Email: akane.kawamura@chem.ox.ac.uk., Hopkinson RJ; Department of Chemistry , University of Oxford , Chemistry Research Laboratory , 12 Mansfield Road , Oxford OX1 3TA , UK . Email: akane.kawamura@chem.ox.ac.uk., Münzel M; Department of Chemistry , University of Oxford , Chemistry Research Laboratory , 12 Mansfield Road , Oxford OX1 3TA , UK . Email: akane.kawamura@chem.ox.ac.uk., Loik ND; Department of Chemistry , Graduate School of Science , The University of Tokyo , Tokyo 113-0033 , Japan., Chowdhury R; Department of Chemistry , University of Oxford , Chemistry Research Laboratory , 12 Mansfield Road , Oxford OX1 3TA , UK . Email: akane.kawamura@chem.ox.ac.uk., Oppermann U; Botnar Research Centre , NIHR Oxford Biomedical Research Unit , University of Oxford , Windmill Road , Oxford , OX3 7LD , UK., Claridge TDW; Department of Chemistry , University of Oxford , Chemistry Research Laboratory , 12 Mansfield Road , Oxford OX1 3TA , UK . Email: akane.kawamura@chem.ox.ac.uk., Goto Y; Department of Chemistry , Graduate School of Science , The University of Tokyo , Tokyo 113-0033 , Japan., Suga H; Department of Chemistry , Graduate School of Science , The University of Tokyo , Tokyo 113-0033 , Japan.; JST , CREST , The University of Tokyo , Tokyo 113-0033 , Japan., Schofield CJ; Department of Chemistry , University of Oxford , Chemistry Research Laboratory , 12 Mansfield Road , Oxford OX1 3TA , UK . Email: akane.kawamura@chem.ox.ac.uk., Kawamura A; Department of Chemistry , University of Oxford , Chemistry Research Laboratory , 12 Mansfield Road , Oxford OX1 3TA , UK . Email: akane.kawamura@chem.ox.ac.uk.; Division of Cardiovascular Medicine , Radcliffe Department of Medicine , University of Oxford , Wellcome Trust Centre for Human Genetics , Roosevelt Drive , Oxford OX3 7BN , UK.

Publikováno v: Chemical science [Chem Sci] 2018 Apr 23; Vol. 9 (20), pp. 4569-4578. Date of Electronic Publication: 2018 Apr 23 (Print Publication: 2018).

Selection-based discovery of macrocyclic peptides for the next generation therapeutics.

Autor: Morioka T; Department of Chemistry, Graduate School of Science, The University of Tokyo, Tokyo 113-0033, Japan., Loik ND; Department of Chemistry, Graduate School of Science, The University of Tokyo, Tokyo 113-0033, Japan., Hipolito CJ; Department of Chemistry, Graduate School of Science, The University of Tokyo, Tokyo 113-0033, Japan., Goto Y; Department of Chemistry, Graduate School of Science, The University of Tokyo, Tokyo 113-0033, Japan., Suga H; Department of Chemistry, Graduate School of Science, The University of Tokyo, Tokyo 113-0033, Japan; CREST, JST, Tokyo 113-0033, Japan. Electronic address: hsuga@chem.s.u-tokyo.ac.jp.

Publikováno v: Current opinion in chemical biology [Curr Opin Chem Biol] 2015 Jun; Vol. 26, pp. 34-41. Date of Electronic Publication: 2015 Feb 20.

Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation.

Autor: Scotti JS; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford OX1 3TA, United Kingdom;, Leung IK; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford OX1 3TA, United Kingdom;, Ge W; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford OX1 3TA, United Kingdom; Chinese Academy of Medical Sciences, Beijing 100005, China;, Bentley MA; Department of Plant Sciences, University of Oxford, Oxford OX1 3RB, United Kingdom;, Paps J; Department of Zoology, University of Oxford, Oxford OX1 3PS, United Kingdom;, Kramer HB; Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford OX1 3QX, United Kingdom; and., Lee J; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford OX1 3TA, United Kingdom;, Aik W; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford OX1 3TA, United Kingdom;, Choi H; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford OX1 3TA, United Kingdom;, Paulsen SM; Department of Plant Sciences, University of Oxford, Oxford OX1 3RB, United Kingdom;, Bowman LA; Department of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom., Loik ND; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford OX1 3TA, United Kingdom;, Horita S; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford OX1 3TA, United Kingdom; Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford OX1 3QX, United Kingdom; and., Ho CH; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford OX1 3TA, United Kingdom;, Kershaw NJ; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford OX1 3TA, United Kingdom;, Tang CM; Department of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom., Claridge TD; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford OX1 3TA, United Kingdom;, Preston GM; Department of Plant Sciences, University of Oxford, Oxford OX1 3RB, United Kingdom;, McDonough MA; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford OX1 3TA, United Kingdom;, Schofield CJ; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford OX1 3TA, United Kingdom; christopher.schofield@chem.ox.ac.uk.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2014 Sep 16; Vol. 111 (37), pp. 13331-6. Date of Electronic Publication: 2014 Sep 02.

Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases.

Autor: Tarhonskaya H; Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK., Rydzik AM; Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK., Leung IK; Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK., Loik ND; Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK., Chan MC; Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK., Kawamura A; Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK., McCullagh JS; Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK., Claridge TD; Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK., Flashman E; Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK., Schofield CJ; Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK.

Publikováno v: Nature communications [Nat Commun] 2014 Mar 05; Vol. 5, pp. 3423. Date of Electronic Publication: 2014 Mar 05.

Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans.

Autor: Ge W; Chemistry Research Laboratory and Oxford Centre for Integrative Systems Biology, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK., Wolf A; Chemistry Research Laboratory and Oxford Centre for Integrative Systems Biology, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK., Feng T; Henry Wellcome Building for Molecular Physiology, University of Oxford, Oxford, OX3 7BN, UK., Ho CH; Chemistry Research Laboratory and Oxford Centre for Integrative Systems Biology, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK., Sekirnik R; Chemistry Research Laboratory and Oxford Centre for Integrative Systems Biology, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK., Zayer A; Henry Wellcome Building for Molecular Physiology, University of Oxford, Oxford, OX3 7BN, UK., Granatino N; Chemistry Research Laboratory and Oxford Centre for Integrative Systems Biology, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK., Cockman ME; Henry Wellcome Building for Molecular Physiology, University of Oxford, Oxford, OX3 7BN, UK., Loenarz C; Chemistry Research Laboratory and Oxford Centre for Integrative Systems Biology, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK., Loik ND; Chemistry Research Laboratory and Oxford Centre for Integrative Systems Biology, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK., Hardy AP; Chemistry Research Laboratory and Oxford Centre for Integrative Systems Biology, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK., Claridge TDW; Chemistry Research Laboratory and Oxford Centre for Integrative Systems Biology, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK., Hamed RB; Chemistry Research Laboratory and Oxford Centre for Integrative Systems Biology, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK., Chowdhury R; Chemistry Research Laboratory and Oxford Centre for Integrative Systems Biology, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK., Gong L; Chemistry Research Laboratory and Oxford Centre for Integrative Systems Biology, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK., Robinson CV; Chemistry Research Laboratory and Oxford Centre for Integrative Systems Biology, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK., Trudgian DC; Biochemistry Dept and Proteomics Core, UT Southwestern Medical Center at Dallas, 6001 Forest Park Rd, Dallas, TX 75390-8816, USA., Jiang M; Chemistry Research Laboratory and Oxford Centre for Integrative Systems Biology, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK., Mackeen MM; Chemistry Research Laboratory and Oxford Centre for Integrative Systems Biology, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK., Mccullagh JS; Chemistry Research Laboratory and Oxford Centre for Integrative Systems Biology, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK., Gordiyenko Y; Chemistry Research Laboratory and Oxford Centre for Integrative Systems Biology, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK., Thalhammer A; Chemistry Research Laboratory and Oxford Centre for Integrative Systems Biology, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK., Yamamoto A; Henry Wellcome Building for Molecular Physiology, University of Oxford, Oxford, OX3 7BN, UK., Yang M; Henry Wellcome Building for Molecular Physiology, University of Oxford, Oxford, OX3 7BN, UK., Liu-Yi P; Henry Wellcome Building for Molecular Physiology, University of Oxford, Oxford, OX3 7BN, UK., Zhang Z; Chemistry Research Laboratory and Oxford Centre for Integrative Systems Biology, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK., Schmidt-Zachmann M; Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center, 69120 Heidelberg, Germany., Kessler BM; Henry Wellcome Building for Molecular Physiology, University of Oxford, Oxford, OX3 7BN, UK., Ratcliffe PJ; Henry Wellcome Building for Molecular Physiology, University of Oxford, Oxford, OX3 7BN, UK., Preston GM; Department of Plant Sciences, University of Oxford, South Parks Road, Oxford, OX1 3RB, UK., Coleman ML; Henry Wellcome Building for Molecular Physiology, University of Oxford, Oxford, OX3 7BN, UK., Schofield CJ; Chemistry Research Laboratory and Oxford Centre for Integrative Systems Biology, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK.

Publikováno v: Nature chemical biology [Nat Chem Biol] 2012 Dec; Vol. 8 (12), pp. 960-962. Date of Electronic Publication: 2012 Oct 28.