Zobrazeno 1 - 10
of 193
pro vyhledávání: '"Loic Yengo"'
Autor:
Liang-Dar Hwang, Gabriel Cuellar-Partida, Loic Yengo, Jian Zeng, Jarkko Toivonen, Mikko Arvas, Robin N. Beaumont, Rachel M. Freathy, Gunn-Helen Moen, Nicole M. Warrington, David M. Evans
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Perinatal traits are influenced by fetal and maternal genomes. We investigate the performance of three strategies to detect loci in maternal and fetal genome-wide association studies (GWASs) of the same quantitative trait: (i) the traditiona
Externí odkaz:
https://doaj.org/article/6ec90594fb2a4675b78cffa420c5cf30
Autor:
Kathryn E. Kemper, Julia Sidorenko, Huanwei Wang, Ben J. Hayes, Naomi R. Wray, Loic Yengo, Matthew C. Keller, Michael Goddard, Peter M. Visscher
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract The causes of temporal fluctuations in adult traits are poorly understood. Here, we investigate the genetic determinants of within-person trait variability of 8 repeatedly measured anthropometric traits in 50,117 individuals from the UK Biob
Externí odkaz:
https://doaj.org/article/d7ac6e5c622e4251826a4171034f62b2
Autor:
Xiaotong Wang, Valentin Hivert, Shiane Groot, Ying Wang, Loic Yengo, John J McGrath, Kathryn E Kemper, Peter M Visscher, Naomi R Wray, Joana A Revez
Publikováno v:
PLoS Genetics, Vol 19, Iss 11, p e1011033 (2023)
Vitamin D status-a complex trait influenced by environmental and genetic factors-is tightly associated with skin colour and ancestry. Yet very few studies have investigated the genetic underpinnings of vitamin D levels across diverse ancestries, and
Externí odkaz:
https://doaj.org/article/f88493a2708348eeb81b39239f4f8f1a
Autor:
Gareth Hawkes, Loic Yengo, Sailaja Vedantam, Eirini Marouli, Robin N Beaumont, GIANT Consortium, Jessica Tyrrell, Michael N Weedon, Joel Hirschhorn, Timothy M Frayling, Andrew R Wood
Publikováno v:
PLoS Genetics, Vol 19, Iss 9, p e1010934 (2023)
Findings from genome-wide association studies have facilitated the generation of genetic predictors for many common human phenotypes. Stratifying individuals misaligned to a genetic predictor based on common variants may be important for follow-up st
Externí odkaz:
https://doaj.org/article/de75353f177a495d861e3958357fc622
Autor:
Zhen Qiao, Julia Sidorenko, Joana A. Revez, Angli Xue, Xueling Lu, Katri Pärna, Harold Snieder, Lifelines Cohort Study, Peter M. Visscher, Naomi R. Wray, Loic Yengo
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Most genetic studies of glucose levels have been done on fasting samples, which can be difficult to obtain. Here, the authors identify 156 genetic loci controlling the physiological variation of glucose levels in healthy non-fasting individuals, demo
Externí odkaz:
https://doaj.org/article/6fde8113956e402caba8686de06ed2d1
Autor:
Jie Huang, Jennifer E. Huffman, Yunfeng Huang, Ítalo Do Valle, Themistocles L. Assimes, Sridharan Raghavan, Benjamin F. Voight, Chang Liu, Albert-László Barabási, Rose D. L. Huang, Qin Hui, Xuan-Mai T. Nguyen, Yuk-Lam Ho, Luc Djousse, Julie A. Lynch, Marijana Vujkovic, Catherine Tcheandjieu, Hua Tang, Scott M. Damrauer, Peter D. Reaven, Donald Miller, Lawrence S. Phillips, Maggie C. Y. Ng, Mariaelisa Graff, Christopher A. Haiman, Ruth J. F. Loos, Kari E. North, Loic Yengo, George Davey Smith, Danish Saleheen, J. Michael Gaziano, Daniel J. Rader, Philip S. Tsao, Kelly Cho, Kyong-Mi Chang, Peter W. F. Wilson, VA Million Veteran Program, Yan V. Sun, Christopher J. O’Donnell
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Elevated body mass index is heritable and associated with many health conditions that impact morbidity and mortality. Here, the authors identify greater than 900 genetic loci for body mass index (BMI) and find over 300 diagnoses associated with incre
Externí odkaz:
https://doaj.org/article/06e868b6d30b40ac93e6e40a0445cc48
Autor:
Richard Border, Sean O’Rourke, Teresa de Candia, Michael E. Goddard, Peter M. Visscher, Loic Yengo, Matt Jones, Matthew C. Keller
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Methods for estimating heritability, the fraction of variance attributable to genetic factors, assume random mating. Here, the authors show that under assortative mating, when mate choice reflects phenotypic similarity, these methods produce overesti
Externí odkaz:
https://doaj.org/article/df9f8cc80d744a7aa180f73386063991
Autor:
Peter M. Visscher, Loic Yengo
Publikováno v:
F1000Research, Vol 11 (2023)
In this study we quantify the accuracy of scoring the quality of research grants using a finite set of distinct categories (1, 2, …., k), when the unobserved grant score is a continuous random variable comprising a true quality score and measuremen
Externí odkaz:
https://doaj.org/article/5e0387e42144433fbae2b005fa7b1737
Autor:
Gita A. Pathak, Kritika Singh, Tyne W. Miller-Fleming, Frank R. Wendt, Nava Ehsan, Kangcheng Hou, Ruth Johnson, Zeyun Lu, Shyamalika Gopalan, Loic Yengo, Pejman Mohammadi, Bogdan Pasaniuc, Renato Polimanti, Lea K. Davis, Nicholas Mancuso
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Genome-wide association studies of COVID-19 have identified genetic loci affecting disease severity, but the mechanisms remain to be fully described. Here, the authors use genetically predicted transcriptome, splicing and proteome data to identify po
Externí odkaz:
https://doaj.org/article/a355ee0c16c940cdb2b6a67d3d67f2b5
Autor:
Eleonora Porcu, Federica Gilardi, Liza Darrous, Loic Yengo, Nasim Bararpour, Marie Gasser, Pedro Marques-Vidal, Philippe Froguel, Gerard Waeber, Aurelien Thomas, Zoltán Kutalik
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract The number of people affected by Type 2 diabetes mellitus (T2DM) is close to half a billion and is on a sharp rise, representing a major and growing public health burden. Given its mild initial symptoms, T2DM is often diagnosed several years
Externí odkaz:
https://doaj.org/article/75360a3d5dfd44c5b36df0daa6ce6d32