Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Loic Herter"'
Autor:
Renyu Guo, Yu-Che Chang, Loic Herter, Christophe Salome, Sarah E. Braley, Thomas C. Fessard, M. Kevin Brown
Publikováno v:
Journal of the American Chemical Society
J Am Chem Soc
J Am Chem Soc
Saturated bicycles are becoming ever more important in the design and development of new pharmaceuticals. Here a new strategy for the synthesis of bicyclo[2.1.1]hexanes is described. These bicycles are significant because they have defined exit vecto
The replacement of the aromatic ring in bioactive com-pounds with saturated bioisosteres has become a popular tactic to obtain novel structures with an improved physico-chemical profile. In this communication, we describe an efficient synthesis of 3,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65f24e6182836f2f7759942234666d45
https://doi.org/10.26434/chemrxiv-2023-6tv1z
https://doi.org/10.26434/chemrxiv-2023-6tv1z
Among the valuable saturated bicyclic structures incorporated in newly developed bio-active compounds, bicyclo[2.1.1]hexanes are playing an increasingly important role, while being still underexplored from a synthetic accessibility point of view. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a4508e00e9f00b28d316fff71b30f0e
https://doi.org/10.26434/chemrxiv-2022-4hc8x
https://doi.org/10.26434/chemrxiv-2022-4hc8x
Autor:
Renyu Guo, Yu-Che Chang, Loic Herter, Christophe Salome, Sarah Braley, Thomas Fessard, Michael Brown
Saturated bicycles are becoming ever more important in the design and development of new pharmaceuticals. In this manuscript, a new strategy for the synthesis of [2.1.1]-bicyclohexanes is described. These bicycles are significant as they have defined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63b550a4a7b48df9665a8304c373756a
https://doi.org/10.26434/chemrxiv-2022-cg9lb
https://doi.org/10.26434/chemrxiv-2022-cg9lb
Autor:
Rachel C. Epplin, Shashwati Paul, Loïc Herter, Christophe Salome, Erin N. Hancock, Jay F. Larrow, Erich W. Baum, David R. Dunstan, Carol Ginsburg-Moraff, Thomas C. Fessard, M. Kevin Brown
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-5 (2022)
The development of new classes of isosteres and building blocks is crucial to the advancement of medicinal chemistry programs. Here, the authors report the synthesis and development of ladderanes to act as replacements for meta-substituted aromatic r
Externí odkaz:
https://doaj.org/article/ebd0a84e99d044029fceee6ab73bf297