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Strain-Release [2π + 2σ] Cycloadditions for the Synthesis of Bicyclo[2.1.1]hexanes Initiated by Energy Transfer

Autor: Renyu Guo, Yu-Che Chang, Loic Herter, Christophe Salome, Sarah E. Braley, Thomas C. Fessard, M. Kevin Brown

Publikováno v: Journal of the American Chemical Society
J Am Chem Soc

Saturated bicycles are becoming ever more important in the design and development of new pharmaceuticals. Here a new strategy for the synthesis of bicyclo[2.1.1]hexanes is described. These bicycles are significant because they have defined exit vecto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25f31c9c56ab2cb2925f3df66cafd75d
https://doi.org/10.1021/jacs.2c02976

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Preparation of 3,5-methanobenzo[b]azepines: a novel sp3-rich Quinolone Isostere

Autor: Loic Herter, Thomas Fessard, christophe Salome

The replacement of the aromatic ring in bioactive com-pounds with saturated bioisosteres has become a popular tactic to obtain novel structures with an improved physico-chemical profile. In this communication, we describe an efficient synthesis of 3,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65f24e6182836f2f7759942234666d45
https://doi.org/10.26434/chemrxiv-2023-6tv1z

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Preparation of new bicyclo[2.1.1]hexane compact modules: an opening towards to novel sp3-rich chemical space

Autor: Loic Herter, Ilias Koutsopetras, Lorenzo Turelli, Thomas Fessard, christophe Salome

Among the valuable saturated bicyclic structures incorporated in newly developed bio-active compounds, bicyclo[2.1.1]hexanes are playing an increasingly important role, while being still underexplored from a synthetic accessibility point of view. Her

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5a4508e00e9f00b28d316fff71b30f0e
https://doi.org/10.26434/chemrxiv-2022-4hc8x

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Strain Release [2p+2s]-Cycloadditions for the Synthesis of [2.1.1]-Bicyclohexanes Initiated by Energy Transfer

Autor: Renyu Guo, Yu-Che Chang, Loic Herter, Christophe Salome, Sarah Braley, Thomas Fessard, Michael Brown

Saturated bicycles are becoming ever more important in the design and development of new pharmaceuticals. In this manuscript, a new strategy for the synthesis of [2.1.1]-bicyclohexanes is described. These bicycles are significant as they have defined

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::63b550a4a7b48df9665a8304c373756a
https://doi.org/10.26434/chemrxiv-2022-cg9lb

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