Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Loic Dreano"'
Autor:
Jianing Liu, Loic Dreano, Keni Vidilaseris, Gustav Boije af Gennäs, Jari Yli-Kauhaluoma, Arthur Lasbleiz, Henri Xhaard, Niklas G. Johansson, Alexandros Kiriazis, Orquidea Marilia de Castro Ribeiro, Adrian Goldman, Ayman Khattab, Seppo Meri
Publikováno v:
Chemmedchem
Inhibition of membrane‐bound pyrophosphatase (mPPase) with small molecules offer a new approach in the fight against pathogenic protozoan parasites. mPPases are absent in humans, but essential for many protists as they couple pyrophosphate hydrolys
Autor:
Niklas G. Johansson, Evgeni Grazhdankin, Loic Dreano, Ayman Khattab, Colin W. G. Fishwick, Ainoleena Turku, Alexandros Kiriazis, Jari Yli-Kauhaluoma, Henri Xhaard, Daniel Ayuso Pérez, Adrian Goldman, Gustav Boije af Gennäs, Aaron Wilkinson, Yuezhou Zhang, Keni Vidilaseris, Matti Tamminen, Seppo Meri
Publikováno v:
ACS Medicinal Chemistry Letters
Membrane-bound pyrophosphatases (mPPases) regulate energy homeostasis in pathogenic protozoan parasites and lack human homologues, which makes them promising targets in e.g. malaria. Yet only few nonphosphorus inhibitors have been reported so far. He