Zobrazeno 1 - 7 of 7 pro vyhledávání: '"Loic Belloy"'
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Akademický článek
Clofoctol inhibits SARS-CoV-2 replication and reduces lung pathology in mice.
Autor: Sandrine Belouzard, Arnaud Machelart, Valentin Sencio, Thibaut Vausselin, Eik Hoffmann, Nathalie Deboosere, Yves Rouillé, Lowiese Desmarets, Karin Séron, Adeline Danneels, Cyril Robil, Loic Belloy, Camille Moreau, Catherine Piveteau, Alexandre Biela, Alexandre Vandeputte, Séverine Heumel, Lucie Deruyter, Julie Dumont, Florence Leroux, Ilka Engelmann, Enagnon Kazali Alidjinou, Didier Hober, Priscille Brodin, Terence Beghyn, François Trottein, Benoit Deprez, Jean Dubuisson
Publikováno v: PLoS Pathogens, Vol 18, Iss 5, p e1010498 (2022)
Drug repurposing has the advantage of shortening regulatory preclinical development steps. Here, we screened a library of drug compounds, already registered in one or several geographical areas, to identify those exhibiting antiviral activity against
Externí odkaz: https://doaj.org/article/ef24a1fe221949deb66833f87060787b
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2
Beyond the Rule of 5: Impact of PEGylation with Various Polymer Sizes on Pharmacokinetic Properties, Structure–Properties Relationships of mPEGylated Small Agonists of TGR5 Receptor
Autor: Florence Leroux, Maxime Culot, Laura Butruille, Fabien Gosselet, Benoit Deprez, Rajaa Boulahjar, Julie Dumont, Mathieu Maingot, Geoffroy Dequirez, Vanessa Hoguet, Anne Tailleux, Manuel Lasalle, Nathalie Hennuyer, Oscar Chávez-Talavera, Isabelle Duplan, Julie Charton, Emmanuel Sevin, Catherine Piveteau, Bart Staels, Loic Belloy, Sophie Lestavel, Adrien Herledan, Alexandre Biela
Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, 2021, 64 (3), pp.1593-1610. ⟨10.1021/acs.jmedchem.0c01774⟩
Journal of Medicinal Chemistry, American Chemical Society, 2021, 64 (3), pp.1593-1610. ⟨10.1021/acs.jmedchem.0c01774⟩
International audience; PEGylation of therapeutic agents is known to improve the pharmacokinetic behavior of macromolecular drugs and nanoparticles. In this work, we performed the conjugation of polyethylene glycols (220-5000 Da) to a series of non-s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44f23dfde7b679d64a3283b670e1d567
https://univ-artois.hal.science/hal-03185533
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3
Clofoctol inhibits SARS-CoV-2 replication and reduces lung pathology in mice
Autor: Thibaut Vausselin, Adeline Danneels, Lowiese Desmarets, Arnaud Machelart, Severine Heumel, Valentin Sencio, Lucie Deruyter, Yves Rouillé, Enagnon Kazali Alidjinou, Cyril Robil, Didier Hober, Sandrine Belouzard, Alexandre Biela, Alexandre Vandeputte, Benoit Deprez, Julie Dumont, Catherine Piveteau, Nathalie Deboosere, Eik Hoffmann, Camille Moreau, François Trottein, Terence Beghyn, Jean Dubuisson, Karin Séron, Florence Leroux, Loic Belloy, Ilka Engelmann, Priscille Brodin
Publikováno v: PLoS Pathogens
PLoS Pathogens, 2022, 18 (5), pp.e1010498. ⟨10.1371/journal.ppat.1010498⟩
PLoS Pathogens, 2022, ⟨10.1371/journal.ppat.1010498⟩
Drug repurposing has the advantage of shortening regulatory preclinical development steps. Here, we screened a library of drug compounds, already registered in one or several geographical areas, to identify those exhibiting antiviral activity against
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::517ce45f1b7ce4e7f5acb50a0202a1e4
https://doi.org/10.1371/journal.ppat.1010498
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4
HDL does not influence the polarization of human monocytes toward an alternative phenotype
Autor: Geesje M. Dallinga-Thie, Mélanie Fanchon, Erik S.G. Stroes, Jan Albert Kuivenhoven, Bruno Derudas, Giulia Chinetti-Gbaguidi, G. Kees Hovingh, Loic Belloy, Bart Staels, Corinne Copin, Andrea E. Bochem, Sophie Colin
Publikováno v: International journal of cardiology, 172(1), 179-184. Elsevier Ireland Ltd
International Journal of Cardiology, 172(1), 179-184. ELSEVIER IRELAND LTD
Background Macrophages are crucial cells in the pathogenesis of atherosclerosis. Macrophages are plastic cells which can switch from a classical pro-inflammatory M1 to an alternative anti-inflammatory M2 macrophage phenotype, depending on the environ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46a6b5e325e75c40e9e9cd8b80f866c5
https://doi.org/10.1016/j.ijcard.2013.12.168
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5
Human Alternative Macrophages Populate Calcified Areas of Atherosclerotic Lesions and Display Impaired RANKL-Induced Osteoclastic Bone Resorption Activity
Autor: Sophie Susen, Bart Staels, Ziad A. Massy, Loïc Louvet, Christophe Zawadzki, Manjula Vinod, Stéphan Haulon, Corinne Copin, Mickael Rosa, Jonathan Vanhoutte, Mehdi Daoudi, Mélanie Fanchon, Jérôme Eeckhoute, Giulia Chinetti-Gbaguidi, Bruno Derudas, Loic Belloy
Publikováno v: Circulation research. 121(1)
Rationale: Vascular calcification is a process similar to bone formation leading to an inappropriate deposition of calcium phosphate minerals in advanced atherosclerotic plaques. Monocyte-derived macrophages, located in atherosclerotic lesions and pr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::655ac5ef3f86a6d8de2063df81b39e6f
https://pubmed.ncbi.nlm.nih.gov/28642321
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6
miR-206 controls LXRα expression and promotes LXR-mediated cholesterol efflux in macrophages
Autor: Manjula, Vinod, Indumathi, Chennamsetty, Sophie, Colin, Loic, Belloy, Federica, De Paoli, Helmut, Schaider, Wolfgang F, Graier, Saša, Frank, Dagmar, Kratky, Bart, Staels, Giulia, Chinetti-Gbaguidi, Gerhard M, Kostner
Publikováno v: Biochimica et Biophysica Acta
Liver X receptors (LXRα and LXRβ) are key transcription factors in cholesterol metabolism that regulate cholesterol biosynthesis/efflux and bile acid metabolism/excretion in the liver and numerous organs. In macrophages, LXR signaling modulates cho
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5af00f756f98dc9e26d9ca382dde06ef
https://pubmed.ncbi.nlm.nih.gov/24603323
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7
LXR controls macrophage iron metabolism
Autor: Mehdi Daoudi, Gael Bories, Sophie Colin, Bruno Derudas, Bart Staels, Stéphan Haulon, Brigitte Jude, Corinne Copin, Mélanie Fanchon, Loic Belloy, Christophe Zawadzki, Jonathan Vanhoutte, Giulia Chinetti-Gbaguidi
Publikováno v: Circulation Research
Circulation Research, American Heart Association, 2013, 113 (11), pp.1196-205. ⟨10.1161/CIRCRESAHA.113.301656⟩
Rationale: In atherosclerotic plaques, iron preferentially accumulates in macrophages where it can exert pro-oxidant activities. Objective: The objective of this study was, first, to better characterize the iron distribution and metabolism in macroph
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd295e5824620e164411a4eaf3ac45a4
https://www.hal.inserm.fr/inserm-00870992
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