Molecular mechanism of GIRK2 channel gating modulated by cholesteryl hemisuccinate.

Autor: Cui M; Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, MA, United States.; Center for Drug Discovery, Northeastern University, Boston, MA, United States., Lu Y; Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, MA, United States., Ma X; Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, MA, United States., Logothetis DE; Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, MA, United States.; Center for Drug Discovery, Northeastern University, Boston, MA, United States.; Affiliate of Chemistry and Chemical Biology, Northeastern University, Boston, MA, United States.; Affiliate of Bioengineering, Northeastern University, Boston, MA, United States.; Affiliate of Roux Institute of Northeastern University, Portland, ME, United States.

Publikováno v: Frontiers in physiology [Front Physiol] 2024 Oct 18; Vol. 15, pp. 1486362. Date of Electronic Publication: 2024 Oct 18 (Print Publication: 2024).

A neurodevelopmental disorder mutation locks G proteins in the transitory pre-activated state.

Autor: Knight KM; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida, Jupiter, FL, USA., Krumm BE; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Kapolka NJ; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Ludlam WG; Department of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida, Jupiter, FL, USA., Cui M; Department of Pharmaceutical Sciences Northeastern University, Boston, MA, USA., Mani S; Department of Pharmaceutical Sciences Northeastern University, Boston, MA, USA., Prytkova I; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Obarow EG; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Lefevre TJ; Department of Pharmacology, University of Michigan, Ann Arbor, MI, USA., Wei W; Department of Computational and Quantitative Medicine, Beckman Research Institute of the City of Hope, Duarte, CA, USA., Ma N; Department of Computational and Quantitative Medicine, Beckman Research Institute of the City of Hope, Duarte, CA, USA., Huang XP; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Fay JF; Department of Biochemistry and Molecular Biology, School of Medicine, University of Maryland, Baltimore, Baltimore, MD, USA., Vaidehi N; Department of Computational and Quantitative Medicine, Beckman Research Institute of the City of Hope, Duarte, CA, USA., Smrcka AV; Department of Pharmacology, University of Michigan, Ann Arbor, MI, USA., Slesinger PA; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Logothetis DE; Department of Pharmaceutical Sciences Northeastern University, Boston, MA, USA., Martemyanov KA; Department of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida, Jupiter, FL, USA., Roth BL; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Dohlman HG; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. hdohlman@med.unc.edu.

Publikováno v: Nature communications [Nat Commun] 2024 Aug 05; Vol. 15 (1), pp. 6643. Date of Electronic Publication: 2024 Aug 05.

A Simple Chiral ¹ H NMR Method for the Discrimination of ( R )- and ( S )-Cannabichromene in Complex Natural Mixtures and Their Effects on TRPA1 Activity.

Autor: Dadiotis E; Laboratory of Pharmacognosy and Natural Products Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimioupolis Zografou, 15771 Athens, Greece.; Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts 02115, United States., Cui M; Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts 02115, United States., Gerasi M; Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts 02115, United States.; Chemistry and Chemical Biology, College of Science, Northeastern University, Boston, Massachusetts 02115, United States., Mitsis V; Ekati Alchemy Lab SL, 08180 Moià, Barcelona, Spain., Melliou E; Laboratory of Pharmacognosy and Natural Products Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimioupolis Zografou, 15771 Athens, Greece., Makriyannis A; Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts 02115, United States.; Chemistry and Chemical Biology, College of Science, Northeastern University, Boston, Massachusetts 02115, United States.; Center for Drug Discovery, Northeastern University, Boston, Massachusetts 02115, United States., Logothetis DE; Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts 02115, United States.; Chemistry and Chemical Biology, College of Science, Northeastern University, Boston, Massachusetts 02115, United States.; Center for Drug Discovery, Northeastern University, Boston, Massachusetts 02115, United States., Magiatis P; Laboratory of Pharmacognosy and Natural Products Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimioupolis Zografou, 15771 Athens, Greece.

Publikováno v: Journal of natural products [J Nat Prod] 2024 Jan 26; Vol. 87 (1), pp. 77-84. Date of Electronic Publication: 2023 Dec 29.

Identification of Sodium- and Chloride-Sensitive Sites in the Slack Channel.

Autor: Xu J; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou 221004, People's Republic of China.; Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou 221004, People's Republic of China.; NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou 221004, People's Republic of China., Lv YT; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou 221004, People's Republic of China.; Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou 221004, People's Republic of China.; NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou 221004, People's Republic of China., Zhao XY; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou 221004, People's Republic of China.; Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou 221004, People's Republic of China.; NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou 221004, People's Republic of China., Wang JJ; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou 221004, People's Republic of China.; Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou 221004, People's Republic of China.; NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou 221004, People's Republic of China., Shen ZS; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou 221004, People's Republic of China.; Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou 221004, People's Republic of China.; NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou 221004, People's Republic of China., Li J; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou 221004, People's Republic of China.; Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou 221004, People's Republic of China.; NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou 221004, People's Republic of China., Zhang FF; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou 221004, People's Republic of China.; Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou 221004, People's Republic of China.; NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou 221004, People's Republic of China., Liu J; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou 221004, People's Republic of China.; Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou 221004, People's Republic of China.; NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou 221004, People's Republic of China., Wang XH; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou 221004, People's Republic of China.; Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou 221004, People's Republic of China.; NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou 221004, People's Republic of China., Xu Y; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou 221004, People's Republic of China.; Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou 221004, People's Republic of China.; NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou 221004, People's Republic of China., Geng Q; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou 221004, People's Republic of China.; Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou 221004, People's Republic of China.; NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou 221004, People's Republic of China., Ding YT; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou 221004, People's Republic of China.; Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou 221004, People's Republic of China.; NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou 221004, People's Republic of China., Xu JJ; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou 221004, People's Republic of China.; Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou 221004, People's Republic of China.; NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou 221004, People's Republic of China., Tan MJ; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou 221004, People's Republic of China.; Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou 221004, People's Republic of China.; NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou 221004, People's Republic of China., Li ZX; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou 221004, People's Republic of China.; Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou 221004, People's Republic of China.; NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou 221004, People's Republic of China., Wang R; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou 221004, People's Republic of China.; Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou 221004, People's Republic of China.; NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou 221004, People's Republic of China., Chen J; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou 221004, People's Republic of China.; Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou 221004, People's Republic of China.; NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou 221004, People's Republic of China., Sun W; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou 221004, People's Republic of China.; Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou 221004, People's Republic of China.; NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou 221004, People's Republic of China., Cui M; Department of Pharmaceutical Sciences, Northeastern University, Boston, Massachusetts 02115., Logothetis DE; Department of Pharmaceutical Sciences, Northeastern University, Boston, Massachusetts 02115., Cao JL; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou 221004, People's Republic of China.; Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou 221004, People's Republic of China.; NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou 221004, People's Republic of China., Tang QY; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou 221004, People's Republic of China qiongyaotang@hotmail.com Zhangzhe70@xzhmu.edu.cn.; Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou 221004, People's Republic of China.; NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou 221004, People's Republic of China., Zhang Z; Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou 221004, People's Republic of China qiongyaotang@hotmail.com Zhangzhe70@xzhmu.edu.cn.; Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou 221004, People's Republic of China.; NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou 221004, People's Republic of China.

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2023 Apr 12; Vol. 43 (15), pp. 2665-2681. Date of Electronic Publication: 2023 Mar 10.

Mechanism of PKCε regulation of cardiac GIRK channel gating.

Autor: Gada KD; Department of Pharmaceutical Sciences, Bouvé College of Health Sciences and College of Science, Northeastern University, Boston, MA 02115., Chang M; Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL 33602., Chandrashekar A; Department of Pharmaceutical Sciences, Bouvé College of Health Sciences and College of Science, Northeastern University, Boston, MA 02115., Plant LD; Department of Pharmaceutical Sciences, Bouvé College of Health Sciences and College of Science, Northeastern University, Boston, MA 02115.; Center for Drug Discovery, Bouvé College of Health Sciences and College of Science, Northeastern University, Boston, MA 02115., Noujaim SF; Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL 33602., Logothetis DE; Department of Pharmaceutical Sciences, Bouvé College of Health Sciences and College of Science, Northeastern University, Boston, MA 02115.; Center for Drug Discovery, Bouvé College of Health Sciences and College of Science, Northeastern University, Boston, MA 02115.; Department of Chemistry and Chemical Biology, Bouvé College of Health Sciences and College of Science, Northeastern University, Boston, MA 02115.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Jan 03; Vol. 120 (1), pp. e2212325120. Date of Electronic Publication: 2022 Dec 30.