Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Logan Vlach"'
Autor:
Gregory Caleb Howard, Jing Wang, Kristie L Rose, Camden Jones, Purvi Patel, Tina Tsui, Andrea C Florian, Logan Vlach, Shelly L Lorey, Brian C Grieb, Brianna N Smith, Macey J Slota, Elizabeth M Reynolds, Soumita Goswami, Michael R Savona, Frank M Mason, Taekyu Lee, Stephen Fesik, Qi Liu, William P Tansey
Publikováno v:
eLife, Vol 12 (2024)
The chromatin-associated protein WD Repeat Domain 5 (WDR5) is a promising target for cancer drug discovery, with most efforts blocking an arginine-binding cavity on the protein called the ‘WIN’ site that tethers WDR5 to chromatin. WIN site inhibi
Externí odkaz:
https://doaj.org/article/843d9e309e8c4e569cdd20374b77da61
Autor:
Peter M. Szabo, Amir Vajdi, Namit Kumar, Michael Y. Tolstorukov, Benjamin J. Chen, Robin Edwards, Keith L. Ligon, Scott D. Chasalow, Kin-Hoe Chow, Aniket Shetty, Mohan Bolisetty, James L. Holloway, Ryan Golhar, Brian A. Kidd, Philip Ansumana Hull, Jeff Houser, Logan Vlach, Nathan O. Siemers, Saurabh Saha
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Epithelial-to-mesenchymal transition (EMT) is associated with tumor initiation, metastasis, and drug resistance. However, the mechanisms underlying these associations are largely unknown. We studied several tumor types to identify the source
Externí odkaz:
https://doaj.org/article/866f80112fea46098f67f5660d88664d
Autor:
Frank M. Mason, Emily S. Kounlavong, Anteneh T. Tebeje, Rashmi Dahiya, Tiffany Guess, Logan Vlach, Stephen R. Norris, Courtney A. Lovejoy, Ruhee Dere, Ryoma Ohi, Peter Ly, Cheryl L. Walker, W. Kimryn Rathmell
SummaryFactors governing the faithful replication of chromosomes are essential for cellular and genomic integrity. While a variety of mechanisms to manage breaks and promote repair of DNA are widely recognized, epigenetic landmarks that preserve telo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0254fa548e9d47cb41bf2f2df61c525
https://doi.org/10.1101/2022.10.25.513694
https://doi.org/10.1101/2022.10.25.513694
Autor:
Luke Frankiw, Annie Moradian, Logan Vlach, Devdoot Majumdar, Christian Burns, David Baltimore, Michael J. Sweredoski
Publikováno v:
Molecular Cell. 73:803-814.e6
Intron retention (IR) occurs in the transcripts of certain genes involved in the inflammatory response. IR decreases the amount of mRNA that can be produced from a given amount of transcript and therefore reduces the protein output from the gene. IR