Výsledky vyhledávání - "Logan V Vick"

Akademický článek

Analysis of tumor-infiltrating NK and T cells highlights IL-15 stimulation and TIGIT blockade as a combination immunotherapy strategy for soft tissue sarcomas

Autor: Shuai Chen, William J Murphy, Robert J Canter, Arta M Monjazeb, Cordelia Dunai, Sean J Judge, Morgan A Darrow, Steve W Thorpe, Alicia A Gingrich, Edmond F O'Donnell, Alyssa R Bellini, Ian R Sturgill, Logan V Vick, Kevin M Stoffel, Yue Lyu, May Cho, Robert B Rebhun

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)

Purpose Given the unmet need for novel immunotherapy in soft tissue sarcoma (STS), we sought to characterize the phenotype and function of intratumoral natural killer (NK) and T cells to identify novel strategies to augment tumor-infiltrating lymphoc

Externí odkaz: https://doaj.org/article/1995ca2108d74b2ba905771479ed7f53

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Akademický článek

Systemic immunostimulation induces glucocorticoid-mediated thymic involution succeeded by rebound hyperplasia which is impaired in aged recipients

Autor: Craig P. Collins, Lam T. Khuat, Gail D. Sckisel, Logan V. Vick, Christine M. Minnar, Cordelia Dunai, Catherine T. Le, Brendan D. Curti, Marka Crittenden, Alexander Merleev, Michael Sheng, Nelson J. Chao, Emanual Maverakis, Spencer R. Rosario, Arta M. Monjazeb, Bruce R. Blazar, Dan L. Longo, Robert J. Canter, William J. Murphy

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

The thymus is the central organ involved with T-cell development and the production of naïve T cells. During normal aging, the thymus undergoes marked involution, reducing naïve T-cell output and resulting in a predominance of long-lived memory T c

Externí odkaz: https://doaj.org/article/1e288536df9248b1a327800dd3a6007e

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Akademický článek

Atezolizumab plus stereotactic ablative radiotherapy for medically inoperable patients with early-stage non-small cell lung cancer: a multi-institutional phase I trial

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)

Abstract Stereotactic ablative radiotherapy (SABR) is a standard-of-care for medically-inoperable-early-stage non-small cell lung cancer (NSCLC). One third of patients progress and chemotherapy is rarely used in this population. We questioned if addi

Externí odkaz: https://doaj.org/article/28952647439e48d680160b1ba89a37c4

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Akademický článek

Regulation of human and mouse bystander T cell activation responses by PD-1

Autor: Catherine T. Le, Logan V. Vick, Craig Collins, Cordelia Dunai, Michael K. Sheng, Lam T. Khuat, Isabel Barao, Sean J. Judge, Ethan G. Aguilar, Brendan Curti, Maneesh Dave, Dan L. Longo, Bruce R. Blazar, Robert J. Canter, Arta M. Monjazeb, William J. Murphy

Publikováno v: JCI Insight, Vol 8, Iss 18 (2023)

Bystander activation of memory T cells occurs via cytokine signaling alone in the absence of T cell receptor (TCR) signaling and provides a means of amplifying T cell effector responses in an antigen-nonspecific manner. While the role of Programmed C

Externí odkaz: https://doaj.org/article/61038b8528944e2fac44a9057e6d02fd

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Akademický článek

Aging augments obesity-induced thymic involution and peripheral T cell exhaustion altering the 'obesity paradox'

Autor: Logan V. Vick, Craig P. Collins, Lam T. Khuat, Ziming Wang, Cordelia Dunai, Ethan G. Aguilar, Kevin Stoffel, Sai Yendamuri, Randall Smith, Sarbajit Mukherjee, Joseph Barbi, Robert J. Canter, Arta M. Monjazeb, William J. Murphy

Publikováno v: Frontiers in Immunology, Vol 13 (2023)

IntroductionThe incidence of obesity, a condition characterized by systemic chronic inflammation, has reached pandemic proportions and is a poor prognostic factor in many pathologic states. However, its role on immune parameters has been diverse and

Externí odkaz: https://doaj.org/article/c987ad8e2be041e09bc0520fda51dba8

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Akademický článek

PD-1 Blockade Reverses Obesity-Mediated T Cell Priming Impairment

Autor: Catherine T. Le, Lam T. Khuat, Sofia E. Caryotakis, Marilyn Wang, Cordelia Dunai, Alan V. Nguyen, Logan V. Vick, Kevin M. Stoffel, Bruce R. Blazar, Arta M. Monjazeb, William J. Murphy, Athena M. Soulika

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Despite obesity reaching pandemic proportions, its impact on antigen-specific T cell responses is still unclear. We have recently demonstrated that obesity results in increased expression of PD-1 on T cells, and checkpoint blockade targeting PD-1/PD-

Externí odkaz: https://doaj.org/article/2cdce341af784b2d9cb499e982fb83d4

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Aging augments obesity-induced thymic involution and peripheral T cell exhaustion altering the 'obesity paradox'

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85da1c6bdcff2d71013cd025a9371ee7
https://escholarship.org/uc/item/4wc2s2wp

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Mechanisms by Which Obesity Promotes Acute Graft

Autor: Lam T, Khuat, Logan V, Vick, Eunju, Choi, Cordelia, Dunai, Alexander A, Merleev, Emanual, Maverakis, Bruce R, Blazar, Arta M, Monjazeb, William J, Murphy

Publikováno v: Frontiers in Immunology

The efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT) is limited by the occurrence of acute and chronic graft-versus-host disease (GVHD). We have recently demonstrated that obesity results in exacerbated acute gastrointestina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::211726284ae60b3fe0bb1f90bf9c8434
https://pubmed.ncbi.nlm.nih.gov/34707616

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Activation status dictates the function of unlicensed natural killer cells in mice and humans

Autor: Craig P Collins, Isabel Barao, Jeffrey S. Miller, Logan V Vick, Cordelia Dunai, Kevin Stoffel, Sean J. Judge, Lam T. Khuat, Ethan G. Aguilar, Christelle Retiere, Patrice Chevallier, Bruce R. Blazar, Maite Alvarez, William J. Murphy, Robert J. Canter, Anthony E. Zamora

Publikováno v: Blood advances, vol 5, iss 20
BLOOD ADVANCES

Natural killer (NK) cells are involved in innate defense against viral infection and cancer. NK cells can be divided into subsets based on the ability of different receptors to bind to major histocompatibility (MHC) class 1 molecules, resulting in di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5819c04f9a79d578f4e8d065cd7c73c
https://pubmed.ncbi.nlm.nih.gov/34496010

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Mouse Preclinical Cancer Immunotherapy Modeling Involving Anti-PD-1 Therapies Reveals the Need to Use Mouse Reagents to Mirror Clinical Paradigms

Autor: Christine M. Minnar, Logan V Vick, Arta M. Monjazeb, Cordelia Dunai, William J. Murphy, Lam T. Khuat, Ziming Wang

Publikováno v: Cancers, vol 13, iss 4
Cancers
Volume 13
Issue 4
Cancers, Vol 13, Iss 729, p 729 (2021)

Simple Summary Immune checkpoint inhibition has revolutionized clinical cancer care. As clinical use of these inhibitors increases, the ability to study the effects of these therapies in preclinical models becomes more important. This study highlight

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64eaeb2a8eea220e718a43f49f1f8b7d
https://escholarship.org/uc/item/2779286q

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