Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Logan R. Wilks"'
Publikováno v:
ACS Infectious Diseases. 8:2389-2395
An improved method for the generation of peptide vaccines using di-tyrosine cross-linking is described. The conserved ion channel peptide, M2e, of influenza A virus was modified with the addition of small tyrosine-rich regions (GYGY-) at both the N-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf74f4f6299bd2f5e36c2c1b9d33a725
https://doi.org/10.1021/acsinfecdis.2c00265
https://doi.org/10.1021/acsinfecdis.2c00265
Autor:
Tony Y. Shay, Carl A. Karouta, Ayush Sharma, Amjad Chowdhury, Jessica J. Hung, Keith P. Johnston, Maria P. Nieto, Kishan Ramachandran, Logan R. Wilks, Barton J. Dear, Thomas M. Truskett, Jason K. Cheung
Publikováno v:
Industrial & Engineering Chemistry Research. 58:22456-22471
To understand and predict the viscosities of highly concentrated monoclonal antibody (mAb) solutions, it is important to characterize the protein–protein interactions (PPI) and how they influence t...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6e2a159f2a08f08392b26692f736a02
https://doi.org/10.1021/acs.iecr.9b03432
https://doi.org/10.1021/acs.iecr.9b03432
Autor:
Logan R. Wilks, Joshua R. Laber, Keith P. Johnston, Jessica J. Hung, Thomas M. Truskett, Barton J. Dear, Ayush Sharma
Publikováno v:
Journal of Pharmaceutical Sciences. 108:2517-2526
An understanding of how cosolutes affect the viscosity and storage stability of highly concentrated mAbs as a function of protein-protein interactions (PPIs) would be desirable for improving processing and administration of protein therapeutics. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54a6695735f0c6472d8eda9b5a041a0d
https://doi.org/10.1016/j.xphs.2019.03.008
https://doi.org/10.1016/j.xphs.2019.03.008
Autor:
P. Douglas Godfrin, Jessica J. Hung, Tony Y. Shay, Jason K. Cheung, Ayush Sharma, Keith P. Johnston, Maria P. Nieto, Amjad Chowdhury, Thomas M. Truskett, Dmytro Nykypanchuk, Jonathan A. Bollinger, Barton J. Dear, Carl A. Karouta, Kishan Ramachandran, Logan R. Wilks
Publikováno v:
The journal of physical chemistry. B. 123(25)
Attractive protein?protein interactions (PPI) in concentrated monoclonal antibody (mAb) solutions may lead to reversible oligomers (clusters) that impact colloidal stability and viscosity. Herein, the PPI are tuned for two mAbs via the addition of ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb07e838aca0990d52e38a8794c881ed
https://pubmed.ncbi.nlm.nih.gov/31146525
https://pubmed.ncbi.nlm.nih.gov/31146525
Autor:
Jonathan A. Bollinger, Jason K. Cheung, P. Douglas Godfrin, Amjad Chowdhury, Barton J. Dear, Thomas M. Truskett, Ayush Sharma, Jessica J. Hung, Kishan Ramachandran, Keith P. Johnston, Tony Y. Shay, Carl A. Karouta, Maria P. Nieto, Logan R. Wilks
Publikováno v:
The journal of physical chemistry. B. 123(4)
The ability to design and formulate mAbs to minimize attractive interactions at high concentrations is important for protein processing, stability, and administration, particularly in subcutaneous delivery, where high viscosities are often challengin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2ae31138bd751a62e26da14ac86505d
https://pubmed.ncbi.nlm.nih.gov/30614707
https://pubmed.ncbi.nlm.nih.gov/30614707