Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Logan Mlakar"'
Autor:
Shailza Sharma, Tomoya Watanabe, Tetsuya Nishimoto, Takahisa Takihara, Logan Mlakar, Xinh-Xinh Nguyen, Matthew Sanderson, Yunyun Su, Roger A. Chambers, Carol Feghali-Bostwick
Publikováno v:
JCI Insight, Vol 6, Iss 24 (2021)
Fibroproliferative disorders such as systemic sclerosis (SSc) have no effective therapies and result in significant morbidity and mortality. We recently demonstrated that the C-terminal domain of endostatin, known as E4, prevented and reversed both d
Externí odkaz:
https://doaj.org/article/1ce1c07c58344779863d1404ddcd74c0
Autor:
Logan Mlakar, Sara M. Garrett, Tomoya Watanabe, Matthew Sanderson, Tetsuya Nishimoto, Jonathan Heywood, Kristi L. Helke, Joseph M. Pilewski, Erica L. Herzog, Carol Feghali-Bostwick
Publikováno v:
Biomedicines, Vol 10, Iss 11, p 2861 (2022)
Organ fibrosis, particularly of the lungs, causes significant morbidity and mortality. Effective treatments are needed to reduce the health burden. A fragment of the carboxyl-terminal end of collagen XVIII/endostatin reduces skin and lung fibrosis. T
Externí odkaz:
https://doaj.org/article/a80803308f4249ff8487842b14caa78d
Autor:
Tomoya Watanabe, Tetsuya Nishimoto, Logan Mlakar, Jonathan Heywood, Maya Malaab, Stanley Hoffman, Carol Feghali-Bostwick
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0179917 (2017)
The murine bleomycin (BLM)-induced fibrosis model is the most widely used in systemic sclerosis (SSc) studies. It has been reported that systemic delivery of BLM via continuous diffusion from subcutaneously implanted osmotic minipumps can cause fibro
Externí odkaz:
https://doaj.org/article/0aa66220825544a5853cf9d4c1b056b0
Autor:
Xinh-Xinh Nguyen, Tetsuya Nishimoto, Takahisa Takihara, Logan Mlakar, Ellen Riemer, Jonathan Heywood, Amy Bradshaw, Carol Feghali-Bostwick
Publikováno v:
Journal of Clinical and Translational Science, Vol 2, Pp 32-33 (2018)
OBJECTIVES/SPECIFIC AIMS: Systemic sclerosis (SSc) is a connective tissue disease of unknown etiology characterized by progressive fibrosis of the skin and multiple visceral organs. Effective therapies for SSc are needed. Lysyl oxidase (LOX) is a cop
Externí odkaz:
https://doaj.org/article/12648607b7854bc285ab75f4505aac07
Autor:
Tomoya Watanabe, DeAnna Baker Frost, Logan Mlakar, Jonathan Heywood, Willian A. da Silveira, Gary Hardiman, Carol Feghali-Bostwick
Publikováno v:
Genes, Vol 10, Iss 2, p 75 (2019)
Systemic sclerosis (SSc) is a complex multi-system autoimmune disease characterized by immune dysregulation, vasculopathy, and organ fibrosis. Skin fibrosis causes high morbidity and impaired quality of life in affected individuals. Animal models do
Externí odkaz:
https://doaj.org/article/326eecda5e4f4ca6b973cdd47d07a151
Autor:
Jessica Lane, Melissa M. Sprachman, Peter Wipf, Carol Feghali-Bostwick, Takahisa Takihara, Chaemin Lim, Logan Mlakar, Kayla R Lloyd
Publikováno v:
ACS Medicinal Chemistry Letters. 11:2312-2317
Fibrosis is a common feature of several diseases, involves different organs, and results in significant morbidity and mortality. There are currently no effective therapies to halt the progression of fibrosis or reverse it. We have identified the high
Autor:
Logan, Mlakar, Jessica, Lane, Takahisa, Takihara, Chaemin, Lim, Melissa M, Sprachman, Kayla R, Lloyd, Peter, Wipf, Carol, Feghali-Bostwick
Publikováno v:
ACS Med Chem Lett
[Image: see text] Fibrosis is a common feature of several diseases, involves different organs, and results in significant morbidity and mortality. There are currently no effective therapies to halt the progression of fibrosis or reverse it. We have i
Autor:
Jonathan Heywood, Logan Mlakar, Carol Feghali-Bostwick, DeAnna Baker Frost, Tomoya Watanabe, Willian A. da Silveira, Gary Hardiman
Publikováno v:
Genes
Volume 10
Issue 2
Genes, Vol 10, Iss 2, p 75 (2019)
Watanabe, T, Baker Frost, D, Mlakar, L, Heywood, J, da Silveira, W A, Hardiman, G & Feghali-Bostwick, C 2019, ' A Human Skin Model Recapitulates Systemic Sclerosis Dermal Fibrosis and Identifies COL22A1 as a TGFβ Early Response Gene that Mediates Fibroblast to Myofibroblast Transition ', Genes, vol. 10, no. 2 . https://doi.org/10.3390/genes10020075
Volume 10
Issue 2
Genes, Vol 10, Iss 2, p 75 (2019)
Watanabe, T, Baker Frost, D, Mlakar, L, Heywood, J, da Silveira, W A, Hardiman, G & Feghali-Bostwick, C 2019, ' A Human Skin Model Recapitulates Systemic Sclerosis Dermal Fibrosis and Identifies COL22A1 as a TGFβ Early Response Gene that Mediates Fibroblast to Myofibroblast Transition ', Genes, vol. 10, no. 2 . https://doi.org/10.3390/genes10020075
Systemic sclerosis (SSc) is a complex multi-system autoimmune disease characterized by immune dysregulation, vasculopathy, and organ fibrosis. Skin fibrosis causes high morbidity and impaired quality of life in affected individuals. Animal models do
Publikováno v:
International Immunopharmacology. 28:1102-1105
Objective Pulmonary fibrosis causes high morbidity and mortality in affected individuals. Recently, we showed that parenteral or intratracheal administration of a peptide derived from endostatin, called E4, prevents and ameliorates fibrosis using dif
Autor:
Sarah A, Beckman, Naosumi, Sekiya, William C W, Chen, Logan, Mlakar, Kimimassa, Tobita, Johnny, Huard
Publikováno v:
CellR4-- repair, replacement, regeneration,reprogramming. 2(2)
Since myoblasts have been limited by poor cell survival after cellular myoplasty, the major goal of the current study was to determine whether improving myoblast survival with an antioxidant could improve cardiac function after the transplantation of