Successful Proof-of-Concept for Topical Delivery of Novel Peptide ALM201 with Potential Usefulness for Treating Neovascular Eye Disorders

Autor: Gideon Obasanmi, PhD, M. Andrew Nesbit, PhD, Diego Cobice, PhD, Logan Mackay, PhD, Stuart McGimpsey, MBBCh, BAO, Mark Wappett, MRes, Aaron N. Cranston, PhD, Tara C.B. Moore, PhD

Publikováno v: Ophthalmology Science, Vol 2, Iss 2, Pp 100150- (2022)

Purpose: To evaluate the therapeutic benefit of a novel peptide, ALM201, in ocular pathologic vascularization. Design: Experimental study in mouse, rat, and rabbit animal models. Participants: Ten-week-old Lister Hooded male rats, 8-week-old Brown No

Externí odkaz: https://doaj.org/article/6440abd86eb14cf8aa97dea51c7fb7fa

Spatial Localization of Vitamin D Metabolites in Mouse Kidney by Mass Spectrometry Imaging

Autor: Karl W. Smith, Bryn Flinders, Paul D. Thompson, Faye L. Cruickshank, C. Logan Mackay, Ron M. A. Heeren, Diego F. Cobice

Publikováno v: ACS Omega, Vol 5, Iss 22, Pp 13430-13437 (2020)

Externí odkaz: https://doaj.org/article/6d27ff997dc74b83878ee9634c98c082

Determining the Location of the α-Synuclein Dimer Interface Using Native Top-Down Fragmentation and Isotope Depletion-Mass Spectrometry

Autor: Kiani Jeacock, Alexandre Chappard, Kelly J. Gallagher, C. Logan Mackay, David P. A. Kilgour, Mathew H. Horrocks, Tilo Kunath, David J. Clarke

Publikováno v: Jeacock, K, Chappard, A, Gallagher, K J, Mackay, C L, Kilgour, D P A, Horrocks, M H, Kunath, T & Clarke, D J 2023, ' Determining the location of the α-synuclein dimer Interface using native top-down fragmentation and isotope depletion-mass spectrometry ', Journal of the American Society for Mass Spectrometry . https://doi.org/10.1021/jasms.2c00339

α-Synuclein (αSyn), a 140-residue intrinsically disordered protein, comprises the primary proteinaceous component of pathology-associated Lewy body inclusions in Parkinson’s disease (PD). Due to its association with PD, αSyn is studied extensive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f582ef9311fb2bc90e083331e48a6e1
https://doi.org/10.1021/jasms.2c00339

Mass spectrometry imaging identifies palmitoylcarnitine as an immunological mediator during Salmonella Typhimurium infection

Autor: Heather E. Hulme, Lynsey M. Meikle, Hannah Wessel, Nicole Strittmatter, John Swales, Carolyn Thomson, Anna Nilsson, Robert J. B. Nibbs, Simon Milling, Per E. Andren, C. Logan Mackay, Alex Dexter, Josephine Bunch, Richard J. A. Goodwin, Richard Burchmore, Daniel M. Wall

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)

Abstract Salmonella Typhimurium causes a self-limiting gastroenteritis that may lead to systemic disease. Bacteria invade the small intestine, crossing the intestinal epithelium from where they are transported to the mesenteric lymph nodes (MLNs) wit

Externí odkaz: https://doaj.org/article/3a24c8a8c4bd40bd88a9c66a0de21e92

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