GDF15 is an exercise-induced hepatokine regulated by glucagon and insulin in humans

Autor: Peter Plomgaard, Jakob S. Hansen, Logan K. Townsend, Anders Gudiksen, Niels H. Secher, Jens O. Clemmesen, Rene K. Støving, Jens P. Goetze, David C. Wright, Henriette Pilegaard

Publikováno v: Frontiers in Endocrinology, Vol 13 (2022)

ObjectiveGrowth differentiation factor (GDF)-15 is implicated in regulation of metabolism and circulating GDF15 increases in response to exercise. The source and regulation of the exercise-induced increase in GDF15 is, however not known.MethodPlasma

Externí odkaz: https://doaj.org/article/ce58d911641d489ab432f2d4f5be64b9

Epinephrine responsiveness is reduced in livers from trained mice

Autor: Hana A. Dibe, Logan K. Townsend, Greg L. McKie, David C. Wright

Publikováno v: Physiological Reports, Vol 8, Iss 3, Pp n/a-n/a (2020)

Abstract The liver is the primary metabolic organ involved in the endogenous production of glucose through glycogenolysis and gluconeogenesis. Hepatic glucose production (HGP) is increased via neural‐hormonal mechanisms such as increases in catecho

Externí odkaz: https://doaj.org/article/bcc2faf8fb7742a18060a7e44ac5e08a

The phosphorylation of AMPKβ1 is critical for increasing autophagy and maintaining mitochondrial homeostasis in response to fatty acids

Autor: Eric M. Desjardins, Brennan K. Smith, Emily A. Day, Serge Ducommun, Matthew J. Sanders, Joshua P. Nederveen, Rebecca J. Ford, Stephen L. Pinkosky, Logan K. Townsend, Robert M. Gutgesell, Rachel Lu, Kei Sakamoto, Gregory R. Steinberg

Publikováno v: Desjardins, E M, Smith, B K, Day, E A, Ducommun, S, Sanders, M J, Nederveen, J P, Ford, R J, Pinkosky, S L, Townsend, L K, Gutgesell, R M, Lu, R, Sakamoto, K & Steinberg, G R 2022, ' The phosphorylation of AMPKβ1 is critical for increasing autophagy and maintaining mitochondrial homeostasis in response to fatty acids ', Proceedings of the National Academy of Sciences of the United States of America, vol. 119, no. 48, e2119824119 . https://doi.org/10.1073/pnas.2119824119

Fatty acids are vital for the survival of eukaryotes, but when present in excess can have deleterious consequences. The AMP-activated protein kinase (AMPK) is an important regulator of multiple branches of metabolism. Studies in purified enzyme prepa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59ff00af91b3737ddb124470677dad36
https://pubmed.ncbi.nlm.nih.gov/36409897

Ketogenic diet-induced weight loss occurs independent of housing temperature and is followed by hyperphagia and weight regain after cessation in mice

Autor: Alyssa Weber, Kyle D. Medak, Logan K. Townsend, David C. Wright

Publikováno v: The Journal of physiologyReferences. 600(21)

Ketogenic diets (KDs) are a popular tool used for weight management. Studies in mice have demonstrated that KDs reduce food intake, increase energy expenditure and cause weight loss. These studies were completed at room temperature, a condition below

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::689c337f53a8fb68c4b96f3829ee7793
https://pubmed.ncbi.nlm.nih.gov/36083198

Reactive oxygen species-dependent regulation of pyruvate dehydrogenase kinase-4 in white adipose tissue

Autor: Pierre-Andre Barbeau, David C. Wright, Graham P. Holloway, Alyssa J. Weber, Logan K. Townsend

Publikováno v: Am J Physiol Cell Physiol

Reactive oxygen species (ROS) are important signaling molecules mediating the exercise-induced adaptations in skeletal muscle. Acute exercise also drives the expression of genes involved in reesterification and glyceroneogenesis in white adipose tiss

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::014058409b1ff63ebfc7a01d910ed5fe
https://doi.org/10.1152/ajpcell.00313.2019