Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Logan J Everett"'
Publikováno v:
Bioinformatics and Biology Insights, Vol 16 (2022)
High-throughput transcriptomics has advanced through the introduction of TempO-seq, a targeted alternative to traditional RNA-seq. TempO-seq platforms use 50 nucleotide probes, each specifically designed to target a known transcript, thus allowing fo
Externí odkaz:
https://doaj.org/article/8b28616d97a847abbaf8053d0e0e327a
Autor:
Victoria Ledbetter, Scott Auerbach, Logan J. Everett, Beena Vallanat, Anna Lowit, Gregory Akerman, William Gwinn, Leah C. Wehmas, Michael F. Hughes, Michael Devito, J. Christopher Corton
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
Current methods for cancer risk assessment are resource-intensive and not feasible for most of the thousands of untested chemicals. In earlier studies, we developed a new approach methodology (NAM) to identify liver tumorigens using gene expression b
Externí odkaz:
https://doaj.org/article/b05c465a5b4645b5b3f97f1d7d895f25
Autor:
Joseph L. Bundy, Richard Judson, Antony J. Williams, Chris Grulke, Imran Shah, Logan J. Everett
Publikováno v:
BioData Mining, Vol 15, Iss 1, Pp 1-27 (2022)
Abstract Background The advent of high-throughput transcriptomic screening technologies has resulted in a wealth of publicly available gene expression data associated with chemical treatments. From a regulatory perspective, data sets that cover a lar
Externí odkaz:
https://doaj.org/article/45f0ba492b9d4425af74642e30de2331
Autor:
Imran Shah, Joseph Bundy, Bryant Chambers, Logan J. Everett, Derik Haggard, Joshua Harrill, Richard S. Judson, Johanna Nyffeler, Grace Patlewicz
Publikováno v:
Chemical Research in Toxicology. 35:1929-1949
Screening new compounds for potential bioactivities against cellular targets is vital for drug discovery and chemical safety. Transcriptomics offers an efficient approach for assessing global gene expression changes, but interpreting chemical mechani
Autor:
Anthony J. F. Reardon, Reza Farmahin, Andrew Williams, Matthew J. Meier, Gregory C. Addicks, Carole L. Yauk, Geronimo Matteo, Ella Atlas, Joshua Harrill, Logan J. Everett, Imran Shah, Richard Judson, Sreenivasa Ramaiahgari, Stephen S. Ferguson, Tara S. Barton-Maclaren
Publikováno v:
Frontiers in Toxicology. 5
The growing number of chemicals in the current consumer and industrial markets presents a major challenge for regulatory programs faced with the need to assess the potential risks they pose to human and ecological health. The increasing demand for ha
Autor:
Adam M Speen, Jessica R Murray, Quentin Todd Krantz, David Davies, Paul Evansky, Joshua A Harrill, Logan J Everett, Joseph L Bundy, Lisa A Dailey, Jazzlyn Hill, Wyatt Zander, Elise Carlsten, Michael Monsees, Jose Zavala, Mark A Higuchi
Publikováno v:
Toxicol Sci
Inhalation is the most relevant route of volatile organic chemical (VOC) exposure; however, due to unique challenges posed by their chemical properties and poor solubility in aqueous solutions, in vitro chemical safety testing is predominantly perfor
Publikováno v:
Molecular Metabolism, Vol 3, Iss 8, Pp 803-812 (2014)
Objective: Glucagon-like peptide-1 (GLP-1) plays a major role in pancreatic β-cell function and survival by increasing cytoplasmic cAMP levels, which are thought to affect transcription through activation of the basic leucine zipper (bZIP) transcrip
Externí odkaz:
https://doaj.org/article/25ac95bac4354a79b996c318b51efa4c
Autor:
Jo Nyffeler, Clinton Willis, Felix R. Harris, M.J. Foster, Bryant Chambers, Megan Culbreth, Richard E. Brockway, Sarah Davidson-Fritz, Daniel Dawson, Imran Shah, Katie Paul Friedman, Dan Chang, Logan J. Everett, John F. Wambaugh, Grace Patlewicz, Joshua A. Harrill
Publikováno v:
Toxicology and Applied Pharmacology. 468:116513
Autor:
Thomas Sheffield, Richard S. Judson, Joseph Bundy, Clinton Willis, Imran Shah, Logan J. Everett, Joshua A. Harrill, Derik E. Haggard, Russell S. Thomas
Publikováno v:
Toxicol Sci
New approach methodologies (NAMs) that efficiently provide information about chemical hazard without using whole animals are needed to accelerate the pace of chemical risk assessments. Technological advancements in gene expression assays have made in
Autor:
Danilo Basili, Joe Reynolds, Jade Houghton, Sophie Malcomber, Bryant Chambers, Mark Liddell, Iris Muller, Andrew White, Imran Shah, Logan J. Everett, Alistair Middleton, Andreas Bender
Publikováno v:
Chemical research in toxicology. 35(4)
Funder: Unilever
Estimation of points of departure (PoDs) from high-throughput transcriptomic data (HTTr) represents a key step in the development of next-generation risk assessment (NGRA). Current approaches mainly rely on single key gene targe
Estimation of points of departure (PoDs) from high-throughput transcriptomic data (HTTr) represents a key step in the development of next-generation risk assessment (NGRA). Current approaches mainly rely on single key gene targe