Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Logan D. Andrews"'
Autor:
Afroza Akhtar, Xueji Zhang, Sacco, Sophie E. Darch, Yu Chen, Kyle G. Kroeck, Logan D. Andrews, John E. Knox, D. Shoun, Frederick Cohen, Emmanuel W. Smith
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports
Scientific Reports
The lipid A biosynthesis pathway is essential in Pseudomonas aeruginosa. LpxA and LpxD are the first and third enzymes in this pathway respectively, and are regarded as promising antibiotic targets. The unique structural similarities between these tw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87f558b64654caf557811871822ccbd2
http://link.springer.com/article/10.1038/s41598-019-51844-z
http://link.springer.com/article/10.1038/s41598-019-51844-z
Autor:
Frederick Cohen, James B. Aggen, Logan D. Andrews, Zahra Assar, Jen Boggs, Taylor Choi, Paola Dozzo, Ashton N. Easterday, Cat M. Haglund, Darin J. Hildebrandt, Melissa C. Holt, Kristin Joly, Adrian Jubb, Zeeshan Kamal, Timothy R. Kane, Andrei W. Konradi, Kevin M. Krause, Martin S. Linsell, Timothy D. Machajewski, Olga Miroshnikova, Heinz E. Moser, Vincent Nieto, Thu Phan, Craig Plato, Alisa W. Serio, Julie Seroogy, Anton Shakhmin, Adam J. Stein, Alex D. Sun, Serguei Sviridov, Zhan Wang, Kenneth Wlasichuk, Wen Yang, Xiaoming Zhou, Hai Zhu, Ryan T. Cirz
Publikováno v:
ChemMedChem. 14:1560-1572
UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC) is a Zn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6a9e4225a28b2cee6c189abdf1bd85c
https://doi.org/10.1002/cmdc.201900287
https://doi.org/10.1002/cmdc.201900287
Publikováno v:
PLoS Biology, Vol 11, Iss 7, p e1001599 (2013)
Enzymes stabilize transition states of reactions while limiting binding to ground states, as is generally required for any catalyst. Alkaline Phosphatase (AP) and other nonspecific phosphatases are some of Nature's most impressive catalysts, achievin
Externí odkaz:
https://doaj.org/article/76204d6dac8141939d34141a45a11c96
Autor:
Ryan Cirz, Ken Wlasichuk, Logan D. Andrews, Zuelay Rosario, Minjong Park, Darin Hildebrandt, Zackery P Bulman, Timothy R. Kane
Publikováno v:
Antimicrob Agents Chemother
The gentamicin drug product is a complex mixture of numerous components, many of which have not individually undergone safety and efficacy assessments. This is in contrast to the majority of medicines that require rigorous characterizations of trace
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfcdd1655ee5787792e24ae1d1a5499f
https://doi.org/10.1128/aac.00533-20
https://doi.org/10.1128/aac.00533-20
Autor:
Lee Swem, Alisa W Serio, Chris M. Pillar, Amanda Burek, Danielle Hall, Frederick Cohen, Ryan Cirz, Kevin M. Krause, Eliana Saxon Armstrong, Christy M. Hebner, Adrian Jubb, Lynn Miesel, Grace Lee, Vincent Nieto, Mary Thwaites, Darrin Hildebrandt, Cat M. Haglund, Machajewski Timothy D, Timothy R. Kane, Meredith Hackel, Logan D. Andrews
Publikováno v:
Antimicrobial Agents and Chemotherapy. 63
New drugs with novel mechanisms of resistance are desperately needed to address both community and nosocomial infections due to Gram-negative bacteria. One such potential target is LpxC, an essential enzyme that catalyzes the first committed step of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aacedbcf86b22e6e1952bd3b6c32722d
https://doi.org/10.1128/aac.00977-19
https://doi.org/10.1128/aac.00977-19
Autor:
Glen McEnroe, Alisa W Serio, Frederick Cohen, Logan D. Andrews, Grover L. Waldrop, Martin S. Linsell, Ryan Cirz, Paola Dozzo, Cat M. Haglund, Darin J. Hilderbrandt, Marc D. Sharp, David B. Neau, Svetlana Pakhomova, Timothy R. Kane, Timothy D. Machajewski, Kenneth B. Wlasichuk, Joe Pogliano
A major challenge for new antibiotic discovery is predicting the physicochemical properties that enable small molecules to permeate Gram-negative bacterial membranes. We have applied physicochemical lessons from previous work to redesign and improve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df8ba653b0941f11f3c77c29062e2792
https://europepmc.org/articles/PMC6980355/
https://europepmc.org/articles/PMC6980355/
Publikováno v:
Antimicrob Agents Chemother
The prevalence of multidrug-resistant Pseudomonas aeruginosa has led to the reexamination of older “forgotten” drugs, such as temocillin, for their ability to combat resistant microbes. Temocillin is the 6-α-methoxy analogue of ticarcillin, a ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20a246d9e733ea214a13c228a8d9c441
https://pubmed.ncbi.nlm.nih.gov/31685462
https://pubmed.ncbi.nlm.nih.gov/31685462
Autor:
Kevin M, Krause, Cat M, Haglund, Christy, Hebner, Alisa W, Serio, Grace, Lee, Vincent, Nieto, Frederick, Cohen, Timothy R, Kane, Timothy D, Machajewski, Darrin, Hildebrandt, Chris, Pillar, Mary, Thwaites, Danielle, Hall, Lynn, Miesel, Meredith, Hackel, Amanda, Burek, Logan D, Andrews, Eliana, Armstrong, Lee, Swem, Adrian, Jubb, Ryan T, Cirz
Publikováno v:
Antimicrobial agents and chemotherapy. 63(11)
New drugs with novel mechanisms of resistance are desperately needed to address both community and nosocomial infections due to Gram-negative bacteria. One such potential target is LpxC, an essential enzyme that catalyzes the first committed step of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e018c1e74a4ab5cd3628401115df7b3a
https://pubmed.ncbi.nlm.nih.gov/31451507
https://pubmed.ncbi.nlm.nih.gov/31451507
Publikováno v:
EcoSal Plus. 8(1)
Aminoglycosides are cidal inhibitors of bacterial protein synthesis that have been utilized for the treatment of serious bacterial infections for almost 80 years. There have been approximately 15 members of this class approved worldwide for the treat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e9fca3bdd18dfc13582c2fbd21223ec
https://pubmed.ncbi.nlm.nih.gov/30447062
https://pubmed.ncbi.nlm.nih.gov/30447062
Publikováno v:
Biochemistry
Catalytic promiscuity, the ability of enzymes to catalyze multiple reactions, provides an opportunity to gain a deeper understanding of the origins of catalysis and substrate specificity. Alkaline phosphatase (AP) catalyzes both phosphate and sulfate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a4568eee86dab7ac6651e0a89142950
http://europepmc.org/articles/PMC4222534
http://europepmc.org/articles/PMC4222534